Admin Core

管理核心

• 批准号: 10592381
• 负责人: David R Andes
• 金额: $ 31.48万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592381
• 关键词: Admin; Core; Admin; Core

Project Summary Antimicrobial innovation has slowed to a crawl while an epidemic of antimicrobial-resistant infections surges, threatening the public health. The overarching goal of the Wisconsin Antimicrobial Drug Discovery and Development Center is to develop therapeutic countermeasures to tackle the antimicrobial resistance crisis. Based upon our preliminary data, we hypothesize that natural product exploration of symbiotic environments using complementary cutting-edge approaches will provide a new paradigm for discovery of novel antimicrobials targeting drug resistant infections. The Center proposes innovative conceptual and technical advances to overcome critical bottlenecks identified in traditional antimicrobial drug discovery platforms. The success of this endeavor hinges upon the cohesive efforts from a diverse group of scientists and technical resources. The Administrative Core will be directed by Andes and advised by an Internal and External Advisory Board comprised of experts in infectious diseases, antimicrobial resistance, drug discovery and development, natural products, and technology transfer and licensing. Additionally, it will include an administrator with extensive experience in research and business administration, and prior oversight of NIH funded program projects and centers. The overall goals of the administrative core are to provide leadership and the organizational back bone for this proposal, promote collaboration between the Projects and Cores, and coordinate its interaction with NIAID staff. /Relevance/ There are no effective therapies for the emerging resistant pathogens that are becoming an increasing threat to the public health. The goals of the Center are to provide new, broad spectrum antimicrobial agents through a collaborative focus on high value natural product leads produced by under-explored sources of biological diversity.

项目摘要 抗菌创新已减慢到爬行，而抗菌感染的流行， 威胁公共卫生。威斯康星州抗菌药物发现的总体目标 开发中心将开发治疗性对策，以应对抗菌抗性危机。 根据我们的初步数据，我们假设自然产品探索共生环境 使用互补的尖端方法将为发现新颖的新范式 靶向抗药性感染的抗菌素。该中心提出了创新的概念和技术 克服传统抗菌药物发现平台中确定的关键瓶颈的进步。这 这项工作的成功取决于多样的科学家和技术的凝聚力努力 资源。行政核心将由安第斯山脉指导，并由内部和外部咨询 董事会由传染病，抗菌素耐药性，药物发现和发育专家组成， 天然产品以及技术转移和许可。此外，它将包括一个管理员 在研究和工商管理方面的丰富经验，以及对NIH资助计划的事先监督 项目和中心。行政核心的总体目标是提供领导和 该建议的组织背骨，促进项目和核心之间的合作以及 协调其与NIAID员工的互动。 /关联/ 对于新兴的抗性病原体没有有效的疗法，它们正在成为日益增长的威胁 到公共卫生。该中心的目标是通过通过 探索生物学来源产生的高价值天然产品线索的合作重点 多样性。