Admin Core

管理核心

• 批准号: 10404413
• 负责人: Marc Nathan Wein
• 金额: $ 22.61万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404413
• 关键词: Acceleration; Advisory Committees; Anabolic Agents; Award; Bioinformatics; Biology; Bone Formation Stimulation; Capsicum; Center for Translational Science Activities; Clinical; Communication; Communities; Data; Development; Genomics; Goals; Grant; Human; Human Resources; Infrastructure; Institution; International; Journals; Leadership; London; Mission; Molecular Mechanisms of Action; Mus; Osteoblasts; Osteocytes; Osteoporosis; Patient Recruitments; Reporting; Research; Research Personnel; Resources; Role; Scientist; Series; Structure; Teleconferences; Time; Trans-Omics for Precision Medicine; Translational Research; Travel; Visit; Work; bone; catalyst; college; improved; inter-institutional; knowledge translation; medical schools; meetings; multidisciplinary; novel therapeutic intervention; professor; progenitor; programs; response; skeletal; success; symposium; transcriptomics; translational research program

Project Summary – Administrative Core The goal of the CORT is to elucidate mechanisms of action of osteoporosis anabolic therapies, and to understand why they stop working over time. In doing so, the CORT will accelerate translation knowledge to improve our understanding of osteoporosis pathobiology. To achieve this goal, the overall focus of the CORT is to define the cellular and molecular mechanisms of action of currently-used osteoporosis anabolic agents in humans. A highly-collaborative, multi- disciplinary, international network of investigators based at several Harvard Medical School- based institutions and Imperial College London have come together to tackle this challenge. The goal of the Administrative Core is to provide administrative support for all aspects of the CORT and its scientific mission. To achieve this goal, three specific aims are proposed. First, the Administrative Core will support the scientific goals of the CORT via coordinating management across projects, supporting a pilot award program, supporting patient recruitment efforts, and facilitating scientific and regulatory reporting. Second, the Administrative Core will provide infrastructure and timely support to ‘unburden’ CORT investigators by coordinating teleconferencing, meeting planning, travel arrangements, and performing post-award grants management. Third, the Administrative Core will function as a ‘hub’ for engagement and dissemination of CORT scientific activities with the broader academic skeletal biology and osteoporosis research communities. These efforts will rely on integration with existing dissemination networks for translational science, a Visiting Professor series, and developing a robust series of platforms to publicize the CORT mission. The Administrative Core leadership structure will involve a director and associate director with appropriate expertise in fundamental, translational, and clinical skeletal biology research, with support from an appropriately-selected External Advisory Committee panel. In sum, the Administrative Core represent an integral component needed for the success of this collaborative, multi-disciplinary, inter-institutional translational research program.

项目摘要 - 行政核心 Cort的目的是阐明骨质疏松症合成代谢疗法的作用机理， 并了解为什么他们随着时间的流逝停止工作。这样，Cort将加速 翻译知识以提高我们对骨质疏松病病理学的理解。实现 这个目标，Cort的总体重点是定义细胞和分子机制 目前使用的骨质疏松症合成代谢剂的作用。高度合并的多种多样的 纪律，国际调查人员网络，位于哈佛医学院的几所 - 位于伦敦的机构和帝国学院已经聚集在一起应对这一挑战。 行政核心的目的是为所有方面提供行政支持 科特及其科学任务。为了实现这一目标，提出了三个具体目标。第一的， 行政核心将通过协调支持Cort的科学目标 跨项目管理，支持试点奖计划，支持患者招聘 努力，并促进科学和监管报告。第二，行政核心将 通过协调为“ Unibenden” Cort调查人员提供基础设施和及时支持 电信，召开计划，旅行安排和执行后授予的赠款 管理。第三，行政核心将充当参与的“枢纽”和 通过更广泛的学术骨骼生物学传播Cort科学活动 骨质疏松研究社区。这些努力将依靠与现有的集成 转化科学的传播网络，访问教授系列，并开发 强大的一系列平台来宣传Cort任务。行政核心领导 结构将涉及一位具有适当专业知识的董事和副主任， 在适当推荐的支持下，翻译和临床骨骼生物学研究 外部咨询委员会小组。总而言之，管理核心代表一个不可或缺的 成功，多学科，机构间成功所需的组成部分 翻译研究计划。