Molecular Mycology: Current Approaches to Fungal Pathogenesis (MoMy) Training Course

分子真菌学：真菌发病机制的最新方法 (MoMy) 培训课程

• 批准号: 10664997
• 负责人: David R Andes
• 金额: $ 10.81万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-04 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664997
• 关键词: Achievement; Address; Affect; Animal Model; Anniversary; Antifungal Agents; Authorship; Biological; Biology; Biomedical Research; Clinical; Collaborations; Communities; Data; Development; Development Plans; Disease; Education; Ethics; Faculty; Funding; Fungi Model; Future; Grant; Health; Human; Humanities; Immune; Immune response; Immunology; Incidence; Instruction; Knowledge; Laboratories; Medical; Mentors; Methods; Microscopy; Mission; Molecular; Molecular Biology; Morbidity - disease rate; Mycoses; National Institute of Allergy and Infectious Disease; Nursing Faculty; Paper; Participant; Pathogenesis; Personal Satisfaction; Pharmaceutical Preparations; Physicians; Positioning Attribute; Procedures; Publishing; Recommendation; Recording of previous events; Research; Research Personnel; Role; Science; Scientist; Students; Surveys; Techniques; Technology; The science of Mycology; Therapeutic; Training; Underrepresented Minority; United States National Institutes of Health; Writing; career; data sharing; drug development; experience; experimental study; faculty mentor; fungus; hands-on learning; immunoregulation; marine; meetings; microbiome components; mortality; novel; pathogen; patient population; peer; programs; research faculty; response; responsible research conduct; skill acquisition; skills; skills training; tenure track

PROJECT SUMMARY The purpose of this application is to support the Molecular Mycology and Pathogenesis education program (MOMY) at the Marine Biological Laboratory (MBL) in Woods Hole, MA. MOMY is now approaching its 25th anniversary at the MBL. Over the course’s history it has provided pivotal training for a scientific workforce to meet the world’s biomedical research needs related to the growing incidence of, and limited therapeutic options for, human fungal infections. Simply put, there is an urgent need for new research with human fungal infections given the rapid advances in immune modulating medical therapies that often result in opportunistic fungal infections. MOMY has addressed both the significant impact of fungi on morbidity and mortality in immune compromised patient populations, as well as the role of fungi as microbiome components that affect health and disease. Our intensive and immersive MOMY program provides trainees hands-on laboratory skill training by leading scientists in the fields of fungal biology, immunology & host response, and antifungal drug development. These skills are critical to develop and promote a well-trained workforce in the face of the growing threat posed by fungi to human well-being. MOMY’s objective during the 2 week course is to provide foundational knowledge and training in the techniques, procedures, and concepts in molecular mycology through direct experiences working with fungi and animal models of fungal disease. Importantly, MOMY provides critical career mentoring and professional development opportunities throughout the course to all participants. We achieve our objective in part through the participation of a diverse and committed faculty who are leading experts from the mycology community. Our specifics aims are: (1) To provide in-depth instruction on fundamental contemporary skills in molecular medical mycology; (2) To provide mentored research opportunities based on cutting edge methods and concepts in molecular medical mycology; and (3) To provide trainees with career mentoring, including professional development advice, science ethics training, and development of a lifelong professional mentoring network. Overall, MOMY has a long history of successfully meeting these aims to advance the NIH Mission and advance our ability to ask, explore, and answer critical questions related to the impact of fungi on human health. The course remains of utmost significance given the increasing scope and incidence of fungi’s impact on humanity and the rapid research technological and conceptual advances occurring in our field.

项目摘要 该应用的目的是支持分子真菌学和发病机理教育计划 （妈妈）在马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）。 Momy现在正在接近25号 MBL周年纪念日。在课程的历史上，它为科学劳动力提供了关键的培训 满足与日益增长和有限治疗的事件相关的世界生物医学研究需求 人类真菌感染的选择。简而言之，迫切需要与人类的新研究 鉴于免疫调节医疗疗法的快速进步，真菌感染通常会导致 机会性真菌感染。 Momy既解决了真菌对发病率的重大影响，又解决了 免疫受损的患者人群的死亡率以及真菌作为微生物组的作用 影响健康和疾病的组成部分。我们的密集和身临其境的妈妈计划为受训者提供 真菌生物学，免疫学和宿主领域的领先科学家的动手实验室技能培训 反应和抗真菌药物开发。这些技能对于发展和促进训练有素的技能至关重要 面对真菌对人类福祉构成的日益严重威胁的劳动力。 Momy的目标 为期2周的课程是提供技术，程序和培训的基础知识和培训 通过与真菌和真菌动物模型一起工作的直接经验，分子真菌学的概念 疾病。重要的是，MOMY提供了关键的职业心理和专业发展机会 通过课程给所有参与者。我们通过参与的部分实现了我们的目标 来自真菌学社区的领先专家的多元化和坚定的教师。我们的细节目标 为：（1）提供有关分子医学真菌学中基本技能的深入指导； （2）根据分子中的尖端方法和概念提供指导的研究机会 医学真菌学； （3）为学员提供职业心理，包括专业发展 建议，科学伦理培训和终身专业心理网络的发展。全面的， Momy有悠久的历史成功地实现了这些目标，以推进NIH任务并促进我们的发展 能够询问，探索和回答与真菌对人类健康的影响有关的关键问题。 鉴于真菌对影响的范围和事件的越来越大的影响 人类和快速研究的技术和概念进步发生在我们的领域。