Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

跨学科神经艾滋病成瘾研究培训（TRAIN）

• 批准号: 10622552
• 负责人: ROBERT Kernachan HEATON
• 金额: $ 42.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622552
• 关键词: Research; Training; addiction; neuroAIDS

PROJECT SUMMARY/ABSTRACT Interdisciplinary clinical research on the combined effects of substance abuse and HIV disease on the central nervous system (CNS) is of considerable public health importance. Despite this, few laboratories address this critical topic and the current training program is the only one dedicated to preparing the next generation of investigators to conduct this research. In this proposed second renewal of our NRSA T32 training grant, “Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN),” we aim to accelerate our contribution to the field. We will continue to recruit talented and diverse pre- and post- doctoral trainees whose academic development will be furthered by an accomplished multidisciplinary team of mentors and the extensive academic resources at UC San Diego. TRAIN has been highly successful in the current funding period–since 2016, the 8 trainees produced 55 research manuscripts (22 first-authored), 88 conference presentations, and 6 book chapters, as well as 2 extramural NIH-funded grants (1 under review, impact score=21, 2nd percentile), 3 supplements to NIH-funded grants, and 2 intramural pilot grants. In this second renewal, we plan to enhance our training grant by augmenting faculty expertise, didactics, and training in new methodologies to support our new complementary theme of the complex biological mechanisms underlying the CNS consequences of HIV and substance use. Factors of particular focus include the microbiome and gut brain-axis, systemic and CNS inflammation, neuroimmunology, and biomarkers. This focus will augment TRAIN continuity themes of neurobehavioral functioning (e.g., frontal systems behaviors, decision-making, memory) and health-related everyday functioning (e.g., treatment adherence, vocational outcomes). Given our previous success and the growing demands of the field, we propose to increase our steady state number of trainees to four pre- and three post-doctoral trainees. Our students and fellows will be actively engaged in individualized career development plans, such as applied research training, didactics, and targeted clinical experiences. TRAIN faculty, all with strong training interests and robust histories of collaborative research, consists of 25 primary mentors across multiple academic levels and disciplines, with considerable expertise across the aforementioned scientific themes. We also have made organizational enhancements (e.g., addition of internal TRAIN committees) to further ensure continued progress towards the accomplishment of trainee goals. TRAIN is led by R. Heaton, Co- Directors I. Grant and D. Moore (new to this role), and Associate Directors J. Iudicello and E. Morgan; this team will oversee all training, scientific, and administrative aspects of the program. TRAIN will be housed at the HNRP-CMCR within the Department of Psychiatry, which is a resource-rich research and training environment in substance abuse and neuroHIV research. Our central goal remains unchanged: to train, mentor, and guide the next generation of researchers on combined CNS effects of HIV and substance use.

项目摘要/摘要 跨学科临床研究对药物滥用和艾滋病毒疾病的综合作用对 中枢神经系统（CNS）是公共卫生重要性的。尽管如此，很少有实验室 解决这个关键主题和当前的培训计划是唯一一个致力于准备下一个的主题 生成研究人员进行这项研究。在我们的NRSA T32的第二次续订中 培训赠款，“跨学科神经辅助研究（火车）的成瘾研究培训”，我们的目标是 加速我们对该领域的贡献。我们将继续招募有才华的和潜水的前后 一支成就良好的多学科团队将进一步发展学术发展的博士学员 圣地亚哥分校的导师和广泛的学术资源。火车在 当前的资助期 - 2016年，8名实习生制作了55次研究手稿（22个首次作者）， 88次会议演讲和6章章节，以及2个由NIH资助的赠款（1个 审查，影响得分= 21，第二个百分点），3份国立大学资助补助金的补充和2个壁内飞行员补助金。 在第二次续约中，我们计划通过增强教师专业知识，教学学， 和新方法的培训，以支持我们的复杂生物学的新主题 艾滋病毒和物质使用后果后果的机制。特别重点的因素 包括微生物组和肠道，全身和中枢神经系统注射，神经免疫学以及 生物标志物。此重点将增强神经行为功能的火车连续性主题（例如额叶 系统行为，决策，记忆）和与健康有关的日常功能（例如治疗 依从性，投票结果）。鉴于我们以前的成功和对该领域的需求不断增长，我们 提议将我们的稳态学员人数增加到四名前和三名博士后学员。我们的 学生和研究员将积极参与个性化的职业发展计划，例如应用 研究培训，教学和针对临床经验。火车教师，都有强大的培训 协作研究的兴趣和稳健的历史，由多个的25位主要导师组成 学术水平和学科，在近似科学主题中具有可观的专业知识。 我们还提高了组织的增强功能（例如，增加内部火车委员会）以进一步 确保朝着实现学员目标实现的继续进步。火车由R. Heaton领导，共同 董事I.这 团队将监督该计划的所有培训，科学和行政方面。火车将被安置 在精神病学系的HNRP-CMCR上，这是一项资源丰富的研究和培训 药物滥用和神经凝血研究的环境。我们的中心目标保持不变：训练， 导师，并指导下一代研究人员对艾滋病毒和药物使用的联合性中枢神经系统效应。

项目成果

Evaluation of Field Sobriety Tests for Identifying Drivers Under the Influence of Cannabis: A Randomized Clinical Trial.

• DOI: 10.1001/jamapsychiatry.2023.2345
• 发表时间: 2023-09-01
• 期刊: JAMA PSYCHIATRY
• 影响因子: 25.8
• 作者: Marcotte, Thomas D.;Umlauf, Anya;Grelotti, David J.;Sones, Emily G.;Mastropietro, Kyle F.;Suhandynata, Raymond T.;Huestis, Marilyn A.;Grant, Igor;Fitzgerald, Robert L.
• 通讯作者: Fitzgerald, Robert L.