Asian Americans & Racism: Individual and Structural Experiences (ARISE)

亚裔美国人

• 批准号: 10900989
• 负责人: Van My Ta Park
• 金额: $ 343.21万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10900989
• 关键词: Aging; Alcohol consumption; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Asian Americans; Biological Markers; Blood; Buffers; COVID-19 pandemic; California; Chinese; Chronic; Clinical; Cognition; Cognitive; Communities; Data; Data Analyses; Data Collection; Databases; Diabetes Mellitus; Discrimination; Education; Family; Foreigner; Frequencies; Functional disorder; Funding; Future; Glial Fibrillary Acidic Protein; Health; Hypertension; Immigrant; Immigration; Impaired cognition; Individual; Koreans; Language; Life Cycle Stages; Light; Memory; Mental Depression; Minority; Modeling; Multilingualism; Neighborhoods; Not Hispanic or Latino; Obesity; Outcome; Pacific Islander; Participant; Prejudice; Prevalence; Prevalence Study; Race; Recording of previous events; Registries; Religion; Religion and Spirituality; Reporting; Research; Resources; Respondent; Risk; Risk Factors; Role; Severities; Site; Smoking; Social support; Socioeconomic Status; Source; Stereotyping; Subgroup; Surface; Surveys; United States; Vietnamese; Visit; anti-Asian; cardiometabolic risk; cardiometabolism; cognitive performance; cognitive testing; cohesion; cohort; collaborative approach; dementia risk; executive function; experience; follow-up; hate crimes; health disparity; health inequalities; human old age (65+); neurofilament; pandemic disease; perceived discrimination; physical inactivity; protective factors; racial bias; racial population; racism; recruit; residential segregation; resilience; sex; social determinants; sociodemographics; tau Proteins; tau-1

Project Summary/Abstract Problem-free”, “perpetual foreigner”, “silent minority”, “all the same” – these are stereotypes that have long plagued Asian Americans (ASAs), often referred to as the “model minority”. ASAs, however, encompasses a diversity of cultures, languages, immigration experiences, socioeconomic status (SES), and religions. Racism and discrimination against ASAs are not new but resurfaced with new intensity during the COVID-19 pandemic. Individual and area level racism and discrimination are tied to significant health disparities that influence risk of Alzheimer’s Disease and Related Dementias (ADRD). For ASAs, racism and discrimination at the individual and area level (e.g., residential segregation; redlining) may result in potential cognitive health disparities; however, this area of research in ASAs is understudied. Limited research suggests that at least some ASA groups have lower ADRD risk than non-Hispanic White individuals. Identification of potential protective factors (e.g., family cohesion) that may mitigate racism-related risk is an important scientific opportunity. Studies examining the role of multi-level discrimination related to ASAs’ risk for ADRD are sorely needed but limited. Our proposed study, Asian Americans & Racism: Individual and Structural Experiences (ARISE), guided by the NIA health disparities framework, will develop a multi-site, multi-lingual cohort in California to study the prevalence as well as the impact of multi-level discrimination and resilience resources on associated risk for ADRD among 1,500 older (≥65 years old) Chinese, Korean, and Vietnamese Americans. We will leverage PI Park’s NIA-funded Collaborative Approach for AAPI Research and Education (CARE) registry as one of our recruitment sources. Our specific aims include: 1) Establish the ARISE cohort to determine the prevalence of life course experiences of multi-level discrimination among older Chinese-, Korean-, and Vietnamese Americans; 2) Evaluate the association of multi-level discrimination on cognitive performance and levels of AD biomarkers, overall and by ASA subgroup, sex, and primary language among ARISE participants. Secondary/exploratory Aim: Evaluate the association between multi-level discrimination and cognitive decline; and 3) Evaluate protective and risk factors that modify the effects of multi-level discrimination on cognitive performance and levels of AD biomarkers among ARISE participants. The scientific promise of ARISE is timely and necessary. The COVID-19 pandemic has exposed and exacerbated anti-Asian racism. ARISE will add to our limited understanding of ASAs who are under-represented and under-engaged in ADRD and aging research.

项目摘要/摘要 无问题的”，“永久外国人”，“沉默的少数派”，“所有相同” - 这些都是刻板印象 长期以来困扰着亚裔美国人（ASA），通常被称为“少数模特”。 asas， 但是，包括各种文化，语言，移民经历， 社会经济地位（SES）和宗教。种族主义和对阿萨斯的歧视不是 新的，但在Covid-19大流行期间以新的强度重新浮出水面。个人和地区层 种族主义和歧视与影响影响风险的重大健康差异有关 阿尔茨海默氏病和相关痴呆症（ADRD）。对于阿萨斯，种族主义和歧视 个体和区域水平（例如，居民种族隔离；红线）可能会导致潜力 认知健康差异；但是，了解ASA的研究领域。有限的 研究表明，至少某些ASA组的ADRD风险低于非西班牙裔 白人。鉴定潜在的受保护因素（例如，家庭凝聚力）可能 减轻与种族有关的风险是一个重要的科学机会。研究检查的作用 与ASAS的ADRD风险相关的多层次歧视是迫切需要的，但有限。我们的 拟议的研究，亚裔美国人与种族主义：个人和结构经历（出现）， 在NIA健康分配框架的指导下，将在 加利福尼亚州研究多层次歧视的患病率和影响 在1,500年龄（≥65岁）中国的ADRD相关风险的相关风险的弹性资源， 韩国人和越南美国人。我们将利用Pi Park的NIA资助合作 AAPI研究和教育（CARE）注册中心的方法是我们的​​招聘资源之一。 我们的具体目的包括：1）确定确定生命盛行的出现队列 老年中国，韩国和 越南美国人； 2）评估认知多层次歧视的关联 整体和ASA亚组，性别和主要的AD生物标志物的性能和水平 出现参与者的语言。次要/探索目的：评估关联 在多层次歧视和认知能力下降之间； 3）评估保护和风险 修改多层次歧视对认知绩效和水平的影响的因素 出现的参与者中的广告生物标志物。出现的科学承诺是及时的， 必要的。 COVID-19的大流行暴露并加剧了反亚洲种族主义。出现 将增加我们对代表不足和参与不足的ASA的有限理解 ADRD和老化研究。