National Alzheimer's Coordinating Center

国家阿尔茨海默病协调中心

• 批准号: 10749285
• 负责人: Walter Anthony Kukull
• 金额: $ 380.33万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749285
• 关键词: Acceleration; Address; Administrative Supplement; Advisory Committees; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; American Indians; Area; Award; Biological Markers; Clinical; Collaborations; Communication; Country; Data; Data Collection; Data Coordinating Center; Data Science; Data Set; Detection; Development; Digital biomarker; Disease; Ensure; FAIR principles; Funding; Future; Genetic; Hispanic Populations; Image; Infrastructure; Interview; Investments; Knowledge; Leadership; Magnetic Resonance Imaging; Minority Groups; Mission; Modality; Modernization; Nature; Parents; Participant; Pathway interactions; Patients; Pilot Projects; Policies; Positioning Attribute; Positron-Emission Tomography; Provider; Research; Research Activity; Research Personnel; Resources; Role; Site; Standardization; Surveys; Technology; Therapeutic; Underserved Population; United States National Institutes of Health; Visualization; Work; cloud based; cognitive testing; data infrastructure; data integration; data management; data repository; data resource; data sharing; data streams; digital; diverse data; electronic data; empowerment; improved; innovation; member; multimodal data; multimodality; neuropathology; outreach; process improvement; programs; recruit; repository

PROJECT SUMMARY Over the past 23 years, the National Alzheimer’s Coordinating Center (NACC) has collaborated with 42 Alzheimer’s Disease Research Centers (ADRCs) across the country to build one of the largest (46,000+ participants), oldest, and most powerful standardized and longitudinal Alzheimer’s datasets in the world. Since our most recent competitive renewal, NACC, working in close coordination with NIA and other ADRC Program stakeholders, has identified significant gaps in areas that are critical for delivering on the full scope of NACC’s U24 parent award. These gaps must be urgently addressed to meet the evolving needs of the ADRC Program and the Alzheimer’s Disease and Related Dementia (ADRD) field and to fulfill NACC's mission. NACC will meet these challenges and amplify the impact of NACC and the ADRCs on ADRD research through this administrative supplement by accelerating the modernization of NACC infrastructure and by expanding NACC’s role as the data, collaboration, and communication hub for the ADRC Program. The proposed new research objectives within this administrative supplement involve significant unanticipated expenses. They are staff-intensive and require investments in new platforms. We have developed a comprehensive strategy for restructuring our team and for building the required technical and programmatic infrastructure to respond to these needs. NACC will build a modern streamlined cloud-based NACC Data Platform and Data Front Door for integrating and sharing existing and innovative standardized multimodal data from across the ADRC Program and other ADRD data coordinating centers. We will also improve processes for how participant data flows through NACC. We will collaborate closely with other ADRD Coordinating Centers and initiatives to improve and create new opportunities for integration and dissemination of standard MRI/PET images, genetic, and biomarker data. We will also collaborate with ADRC member sites to pilot multisite digital neuropathology and digital cognitive test data collection and integration. Additionally, we will improve our reach through a reimagined communication and collaboration strategy with new pathways to disseminate impact as well as improve our facilitation of ADRC consortium governance and collaboration with additional support for ADRC groups and initiatives. Finally, we are improving ADRC data diversity by creating onramps for ADRCs to recruit and retain more participants from historically minoritized populations highly impacted by ADRD. Together, this work amplifies NACC’s impact and scope of work as the data, collaboration, and coordination hub for the ADRC Program with the aim of significantly improving ADRC research impact.

项目摘要 在过去的23年中，国家阿尔茨海默氏症协调中心（NACC）与42 全国各地建造最大的阿尔茨海默氏病研究中心（ADRC）（46,000多个 参与者），世界上最古老，最有力的标准化和纵向阿尔茨海默氏症的数据集。自从 我们最近的竞争续约NACC与NIA和其他ADRC计划密切协调 利益相关者已经确定了在NACC的全部范围至关重要的领域中的巨大差距 U24父母奖。这些差距必须紧急解决，以满足ADRC计划不断发展的需求 以及阿尔茨海默氏病和相关痴呆症（ADRD）领域，并履行NACC的使命。 NACC将见面 这些挑战和放大器通过这种行政管理对NACC和ADRC对ADRD研究的影响 通过加速NACC基础设施的现代化并扩大NACC的作用来补充补充 ADRC计划的数据，协作和通信中心。拟议的新研究目标 在此行政补充中，涉及大量意外支出。他们是员工密集型的 需要在新平台上进行投资。我们已经制定了重组团队的全面策略 并建立所需的技术和程序基础架构来响应这些需求。 NACC会 建立一个现代化的基于云的NACC数据平台和数据前门，用于集成和共享 来自ADRC程序和其他ADRD数据的现有和创新的标准化多模式数据 协调中心。我们还将改善参与数据如何通过NACC流动的过程。我们将 与其他ADRD协调中心和计划密切合作，以改善和创建新的 标准MRI/PET图像，遗传和生物标志物数据的整合和传播的机会。我们 还将与ADRC成员站点合作以进行多站点数字神经病理和数字认知测试 数据收集和集成。此外，我们将通过重新想象的沟通和 合作策略，采用新的途径来传播影响和改进我们的ADRC设施 财团治理和合作，并为ADRC团体和计划提供额外的支持。最后，我们 通过为ADRC创建招聘和保留更多参与者的范围来改善ADRC数据多样性 历史上少数人口受ADRD的影响。这项工作放大器NACC的影响和 ADRC计划的数据，协作和协调中心的工作范围，目的是 改善ADRC研究影响。

项目成果

Neuropsychological Decline Stratifies Dementia Risk in Cognitively Unimpaired and Impaired Older Adults.

• DOI: 10.3389/fnagi.2022.838459
• 发表时间: 2022
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8

Traumatic Brain Injury Characteristics Are Not Related to Neurocognitive Decline in Older Adults: A Nationwide Longitudinal Cohort Study.

创伤性脑损伤特征与老年人神经认知能力下降无关：一项全国纵向队列研究。

• DOI: 10.1093/arclin/acae003
• 发表时间: 2024
• 期刊: Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
• 作者: Schaffert,Jeff;LoBue,Christian;Chiang,Hsueh-Sheng;Peters,MatthewE;HartJr,John;Cullum,CMunro
• 通讯作者: Cullum,CMunro

Noniterative adjustment to regression estimators with population‐based auxiliary information for semiparametric models

使用半参数模型的基于总体的辅助信息对回归估计进行非迭代调整

• DOI: 10.1111/biom.13585
• 发表时间: 2021
• 期刊: Biometrics
• 影响因子: 1.9
• 作者: Gao, Fei;Chan, K. C. G.
• 通讯作者: Chan, K. C. G.