NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)

国家阿尔茨海默病协调中心 (NACC)

• 批准号: 6922807
• 负责人: Walter Anthony Kukull
• 金额: $ 281.54万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6922807
• 关键词: Alzheimer' s disease; Internet; cooperative study; data collection; data management; experimental designs; health science research support; human data; information systems; longitudinal human study; method development; neuropathology

DESCRIPTION (provided by applicant): This is the Competing Continuation application of the National Alzheimer's Coordinating Center (NACC). Between about 1984 and 1997, no data were centrally collected for the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging. Establishment of an interim data center and a Minimum Data Set in about 1997 led to the NIA issuance of an RFA for an Alzheimer's Disease Data Coordinating Center. Since receiving the interim center Minimum Data Set (MDS), NACC has successfully refined and expanded the overall database, reduced missing data, increased data validity, expanded neuropathological data, added Center-wide data surveys, and increased accessibility to the data through the use of web-based data access and entry. The capabilities provided for use of combined ADC data have not been experienced by the ADCs prior to the establishment of NACC. With over 60,000 subjects, this is currently the largest Alzheimer's and related disorders database ever assembled in the U.S. NACC was additionally charged with increasing collaboration between the ADCs, not only through the use of the MDS but also through the promotion of investigator-initiated collaborative projects and the provision of statistical, methodological and database management consulting to the ADCs and for the collaborative projects. In the next grant cycle, NACC will continue to expand on these efforts. The Uniform Data Set (UDS) has now been mandated for use in all ADCs by NIA. NACC will build a database structure to implement the UDS, collect the data and integrate it seamlessly with the existing data. NACC will develop a means of capturing referral source and selection method data for all new UDS enrollees. These data will help describe and increase the external validity of analyses which use the database and will form the basis for ADCs to select the most comparable controls for their cases. NACC will continue its successful collaborative project program and will also encourage small secondary data analysis studies from junior investigators. NACC will continue design and analysis consulting, and expand its efforts to increase communication and collaboration through the NACC web site. NACC will also conduct its own data analyses and develop methodological research relevant to the needs of the ADCs and research in general. Finally, NACC will continue its administrative coordinating activities to facilitate meetings of the ADC Directors and Core Leaders.

描述（由申请人提供）：这是国家阿尔茨海默氏症协调中心（NACC）的竞争连续申请。在大约1984年至1997年之间，没有针对国家老龄研究所资助的29个阿尔茨海默氏病中心（ADC）收集的数据。在1997年左右建立了临时数据中心和最低数据设置，导致NIA发行了阿尔茨海默氏病数据协调中心的RFA。自从收到临时中心最小数据集（MDS）以来，NACC成功地完善并扩展了整体数据库，减少了丢失的数据，提高数据有效性，扩展了神经病理学数据，添加了中央范围的数据调查，并通过使用基于Web的数据访问和输入来提高数据可访问性。在建立NACC之前，ADC尚未经历过使用ADC数据提供的功能。目前，拥有60,000多名受试者，是美国有史以来最大的阿尔茨海默氏症和相关疾病数据库。 NACC还被指控不仅通过使用MD，而且还通过促进调查员发起的协作项目以及向ADCS和协作项目提供统计，方法论和数据库管理咨询，还通过促进调查员发起的协作项目来增加协作。在下一个赠款周期中，NACC将继续扩大这些努力。 NIA现在已授权统一的数据集（UDS）在所有ADC中使用。 NACC将构建一个数据库结构来实现UD，收集数据并与现有数据无缝集成。 NACC将开发一种捕获所有新UDS参与者的转介源和选择方法数据的方法。这些数据将有助于描述和增加使用数据库的分析的外部有效性，并将为ADC选择其案例最可比的控件构成基础。 NACC将继续其成功的协作项目计划，还将鼓励初级研究人员的小型二级数据分析研究。 NACC将继续设计和分析咨询，并扩大其通过NACC网站增加沟通和协作的努力。 NACC还将进行自己的数据分析，并开发与ADC和总体研究需求有关的方法论研究。最后，NACC将继续其行政协调活动，以促进ADC董事和核心领导者的会议。