Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence

重温 ReCHARGE：ECHO 对童年中期和青春期的跟进

基本信息

批准号：
10745252
负责人：
Deborah Hall Bennett
金额：
$ 123.23万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10745252
关键词：
Address Adolescence Adolescent Affect Affective Age Air Pollution Aliquot Anxiety Area Attention Attention deficit hyperactivity disorder Attentional deficit Behavior Behavioral Biological Biological Factors Black race Blood Brain Cell Differentiation process Characteristics Charge Chemical Exposure Chemicals Child Child Health Childhood Cognition Cognitive Cognitive deficits Collection Consultations DNA Data Data Collection Development Developmental Delay Disorders Diagnosis Diagnostic Factor Emotional Emotions Enrollment Environment Environmental Exposure Environmental Risk Factor Epigenetic Process Ethnic Origin Ethnic Population Evaluation Exposure to Family Fetal health Financial Hardship Funding Goals Green space Happiness Health Health Insurance Portability and Accountability Act Hispanic Home Household Household Products Hyperactivity Impairment Impulsivity Indigenous Individual Influentials Infrastructure Institutional Review Boards Intellectual functioning disability Intervention Irritable Mood Knowledge Leadership Life Link Measures Mental Depression Mental Health Modification Moods Neighborhoods Neuroglia Neurons Neurosciences Occupations Outcome Outcome Measure Paper Parents Participant Pattern Pediatric cohort Peer Review Pesticides Phase Plasticizers Play Policies Process Productivity Protocols documentation Puberty Public Health Publications Race Radiation Regulation Research Resources Risk Risk Factors Role SNP array Schools Science Site Social Justice Subgroup Symptoms Syndrome System Time Urine Visit Work Youth adolescent health anxiety symptoms autism spectrum disorder autistic biobank cognitive function cognitive skill cohort depressive symptoms diversity and equity early childhood environmental justice environmental stressor experience falls follow-up high risk improved inattention indexing lead exposure longitudinal design middle childhood multi-racial myelination neurodevelopment novel peer phthalates postnatal prenatal prognostic programs racial population resilience factor retention rate sex social social factors social stressor stressor substance use synaptogenesis therapy design working group

项目摘要

Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD), developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000 biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for analyzing novel chemicals from common but understudied household products, and blood for multiple uses. The UC Davis ECHO team led a number of analysis proposals, authored/co- authored 40 peer-reviewed papers, with another 50 in-progress. The Team also contributed to developing ECHO policies and participated in and led various working groups, such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND Institute. In ECHO Phase 2, the UCD Aim 1 will: examine environmental, social, and biologic exposures in associations with externalizing and internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and identify both synergistic relationships between environmental and social factors, especially environmental justice and social justice, and potential modification of exposure-outcome associations by early childhood developmental diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the same exposures, plus measures of PFAS and plasticizers for associations with longitudinal trajectories of the above behavioral and emotional outcomes, as well as cognitive skills. In both aims: environmental exposures include air pollution, greenspace, and home product use; social factors are neighborhood SES, family financial hardship, race, ethnicity, and parental mental health or substance use problems. Aim 3 will implement the final ECHO protocol with high fidelity, maximize retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UCD will continue to contribute broadly to the ECHO infrastructure; advance the science through analysis and publications; promote diversity and equity through our research questions, workforce, and retention strategies; and actively participate & play leadership roles in this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.

从 2016 年秋季开始，加州大学戴维斯分校儿科队列 ReCHARGE 获得了新的资助环境对儿童健康结果的影响 (ECHO) 联盟包括近 80 个站点。现在处于 ECHO 第一阶段的第 7 年，加州大学戴维斯分校已招收约 900 名儿童来自三个神经发育组儿童的 ECHO：自闭症谱系障碍 (ASD)、无自闭症症状的发育迟缓（DD）和典型发育（TD）；已上传超过 55,000 份数据收集表格传输至 ECHO 队列数据平台，并传输超过 8000 将生物样本等分至 ECHO 生物样本库，包括用于 SNP 阵列的 DNA、用于检测尿液的样本分析常见但未充分研究的家用产品和血液中的新型化学物质多种用途。加州大学戴维斯分校 ECHO 团队领导了许多分析提案，撰写/共同撰写撰写了 40 篇同行评审论文，另有 50 篇正在进行中。该团队还做出了贡献制定 ECHO 政策并参与和领导各个工作组，例如神经发育、化学暴露、表观遗传学以及出版物委员会，政策实施和评估等。 ECHO-ReCHARGE 队列重点关注神经发育的 ECHO 领域，由加州大学戴维斯分校 MIND 研究所推动。在 ECHO 第 2 阶段，UCD 目标 1 将：检查环境、社会和生物暴露与外化和内化行为的关联，即多动症症状、焦虑 8-20岁的抑郁症；并确定环境之间的协同关系和社会因素，特别是环境正义和社会正义，以及潜在的修改通过儿童早期发育诊断（ASD、DD、TD）确定暴露与结果的关联，年龄、性别和青春期状态。目标 2 将评估相同的暴露以及 PFAS 的测量和增塑剂与上述行为的纵向轨迹的关联情绪结果以及认知技能。在这两个目标中：环境暴露包括空气污染、绿地和家居产品的使用；社会因素包括邻里社会经济地位、家庭经济困难、种族、民族以及父母的心理健康或药物使用问题。目标 3 将实施最终的 ECHO 协议，具有高保真度、最大限度地保留并坚持遵守所有 ECHO 政策、IRB、HIPAA 和其他法规。都柏林大学将继续做出广泛贡献 ECHO 基础设施；通过分析和出版物推进科学发展；推动通过我们的研究问题、劳动力和保留策略实现多样性和公平性；和积极参与并在这个引人注目的独特计划中发挥领导作用，以发现儿童健康和发展的潜在风险和复原力因素。