Research and Mentoring on Neurocognitive Disparities in Aging

衰老过程中神经认知差异的研究和指导

• 批准号: 10747198
• 负责人: Maria Marquine
• 金额: $ 18.64万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747198
• 关键词: Acculturation; Administrative Supplement; Age; Aging; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Award; Awareness; Biological Process; COVID-19 pandemic effects; California; Cellular Phone; Clinical; Clinical Psychology; Cognitive; Cognitive aging; Data; Development; Discrimination; Disparity; Early identification; Environmental Risk Factor; Fostering; Funding; HIV; Hispanic; Hispanic Populations; Infrastructure; International; Intervention; Joints; K-Series Research Career Programs; Language; Latin America; Latina; Latina Population; Latino Population; Leadership; Mental Health; Mentors; Metabolic syndrome; Midcareer Investigator Award in Patient-Oriented Research; Minority; Minority Groups; Neurocognitive; Neurocognitive Deficit; Neuropsychological Tests; Neuropsychology; Not Hispanic or Latino; Pilot Projects; Population; Positioning Attribute; Principal Investigator; Process; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Science; Scientist; Time; Training; Training Programs; Training and Infrastructure; Underrepresented Minority; United States; United States National Institutes of Health; Universities; Work; bilingualism; career; dementia risk; disadvantaged background; dysbiosis; early-career faculty; education research; experience; gut microbiome; health literacy; high risk; high school; improved; innovation; minority trainee; mobile computing; neurobehavioral; patient oriented research; programs; protective factors; skills; social culture; stem; tool; tool development

PROJECT SUMMARY The proposed K24 Midcareer Investigator Award in Patient-Oriented Research aims to best enable the Principal Investigator, Dr. María Marquine, to advance research on neurocognitive disparities in aging and Alzheimer’s Disease and Related Dementias (ADRDs) among Hispanics/Latinos/as/x (henceforth Hispanics). Dr. Marquine’s research program has centered around two major themes: 1) the identification of risk and protective factors for neurocognitive decline among older Hispanics with and without HIV, and 2) the development of tools for the accurate identification of neurocognitive impairment among Spanish-speakers in the United States. More recently, she has extended this latter focus to include the use of ubiquitous mobile technology for the identification of ADRD risk. Dr. Marquine is passionate about mentoring and supporting the advancement of early career scientists, particularly those from underrepresented minority (URM) backgrounds. Approximately 80% of her mentees have been from disadvantaged backgrounds, and her mentees have spanned various career stages, from high-school to early career faculty. She is currently a co-Investigator on two NIA-funded research education programs, the San Diego Alzheimer’s Disease-Resource Center for Minority Aging Research (AD-RCMAR) and the University of California San Diego (UCSD) Advancing Diversity through Aging Research (ADAR) program, and Deputy Director of an R25 Research Education Program on aging and HIV. She is also a mentor in the UCSD Hispanic Center of Excellence, several NIH-funded T32 training programs housed at UCSD, and the San Diego State University (SDSU)/UCSD Joint Doctoral Program in Clinical Psychology. Attaining a Midcareer Investigator Award would allow Dr. Marquine protected time to continue advancing her research program in neurocognitive disparities and ADRD, deepen her commitment to mentor junior clinical scientists in the conduct of research in this area, and obtain formal training in mentoring and leadership skills. The award would also provide support for the development of neuropsychological normative standards to detect neurocognitive impairment associated with ADRDs among older Spanish-speakers, which is a necessary step toward the advancement of ADRD research in this understudied group. In her research and mentoring activities, Dr. Marquine will leverage resources available within three major research centers at UCSD, namely, the Stein Institute for Research on Aging, the Shiley-Marcos Alzheimer’s Disease Research Center, and the HIV Neurobehavioral Research Program. Together, these research centers have built and maintain a highly effective research and training infrastructure that will serve as an important resource for Dr. Marquine’s own research program and that of her mentees.

项目摘要 拟议的K24中级护理研究员授予患者的研究奖旨在使校长能够充分利用 调查员玛丽亚·马奎内（MaríaMarquine 西班牙裔/拉丁美洲裔/AS/X（此后西班牙裔）中的疾病和相关痴呆症（ADRDS）。 Marquine博士 研究计划以两个主要主题为中心：1）识别风险和受保护因素的因素 有或没有艾滋病毒的老年西班牙裔的神经认知下降，以及2）开发工具的工具 在美国，西班牙语扬声器之间的神经认知障碍的准确鉴定。更多的 最近，她扩大了以后的重点，包括使用无处不在的移动技术。 确定ADRD风险。 Marquine博士热衷于心理和支持 早期的职业科学家，特别是来自代表性不足的少数民族（URM）背景的科学家。大约 她的梅内斯（Menees）中有80％来自不利的背景，她的梅内斯（Menees）跨越了各种 职业阶段，从高中到早期职业教师。她目前是两个NIA资助的共同投资者 研究教育计划，圣地亚哥阿尔茨海默氏病疾病资源少数民族老龄化研究中心 （AD-RCMAR）和加利福尼亚大学圣地亚哥分校（UCSD）通过老龄化研究提高多样性 （ADAR）计划，以及R25衰老和艾滋病毒研究教育计划的副主任。她也是一个 UCSD西班牙裔卓越中心的导师，在UCSD中安置的几项NIH资助的T32培训计划 以及圣地亚哥州立大学（SDSU）/UCSD临床心理学联合博士课程。达到 中级护理调查员奖将使Marquine博士受到保护的时间继续前进她的研究 神经认知分布和ADRD的计划，加深了她对心理初级临床科学家的承诺 在这一领域进行研究，并获得心理和领导能力方面的正式培训。奖项 还将为发展神经心理规范标准的发展提供支持 较旧的西班牙扬声器中与ADRD相关的神经认知障碍，这是必要的步骤 在这个知识的小组中促进ADRD研究的发展。在她的研究和心理活动中 Marquine博士将利用UCSD的三个主要研究中心的可用资源，即Stein 老化研究所，Shiley-Marcos阿尔茨海默氏病研究中心和艾滋病毒 神经行为研究计划。这些研究中心共同建立并保持高效 研究和培训基础设施将成为Marquine博士自己研究的重要资源 节目和她的梅内斯。