Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints - Administrative Supplement

饮酒水平（酗酒、饮酒量）和酒精后果：使用国家数据确定临床试验终点 - 行政补充

• 批准号: 10228425
• 负责人: DEBORAH S HASIN
• 金额: $ 1.59万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-10 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228425
• 关键词: Acculturation; Address; Administrative Supplement; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic Intoxication; Alcohols; Anxiety Disorders; Asians; Biological; Bisexual; Cardiovascular Diseases; Characteristics; Clinical Trials; Consumption; DSM-V; Data; Data Analyses; Detection; Discrimination; Drug Use Disorder; Elderly; Epidemiology; Family history of; Female; Gays; Gender; General Population; Genetic; Grant; Health; Health Personnel; Health Professional; Heavy Drinking; Heritability; Impairment; Individual; Knowledge; Lesbian; Literature; Liver diseases; Measures; Minority Groups; Outcome; Paper; Parents; Participant; Patients; Pharmaceutical Preparations; Pregnancy; Provider; Publications; Randomized Clinical Trials; Risk; Risk Factors; Running; Siblings; Socioeconomic Status; Stress; Time; U-Series Cooperative Agreements; United States National Institutes of Health; Work; World Health Organization; Writing; Youth; alcohol consequences; alcohol effect; alcohol epidemiology; alcohol response; alcohol risk; alcohol use disorder; brief intervention; college; comorbidity; cost; depressive symptoms; design; drinking; epidemiologic data; experience; falls; high risk; improved; male; member; middle age; parent grant; response; screening; screening and brief intervention; sexual minority; sexual relationship; user-friendly; work-study; young adult

PROJECT SUMMARY In the project, “Drinking Levels (Binge, Volume) And Alcohol Consequences: Using National Data To Identify Clinical Trial Endpoints” (R01AA025309), epidemiologic data have been used to investigate the relationship of heavy drinking indicators to the risk for alcohol dependence and other drinking consequences. Much of the work for this study has focused on whether non-abstinent drinking reductions improve how individuals feel and function across a broad range of domains. In the project, drinking reduction has primarily been measured by the World Health Organization (WHO) risk drinking levels: very high risk, high risk, moderate risk, and low risk. These represent gender-specific average volumes of ethanol consumed per day. Health outcomes have covered a broad range of domains, including alcohol dependence (occurrence, persistence), impaired functioning, liver disease, AUDIT-C screening scores, drug use disorders, depressive/anxiety disorders, and cardiovascular disease. The project has also contributed to papers addressing similar issues regarding WHO risk drinking levels in treatment data from randomized clinical trials. However, the study did not include the relationship of WHO risk drinking levels to additional important variables that are often highly related to drinking levels and also to the outcomes already analyzed. In particular, these additional variables include tolerance to alcohol; family history of alcohol use disorders; and sexual minority status. In addition, no information exists on whether experiencing discrimination as a member of a sexual minority group moderates the relationship of sexual minority status to WHO risk drinking levels. Therefore, Aim 1 of this administrative supplement is to conduct these additional analyses on WHO risk drinking levels and alcohol tolerance, family history of alcohol use disorders, and sexual minority status, which will involve unanticipated costs. Furthermore, no document exists that summarizes extant information on the epidemiology of heavy drinking and alcohol use disorders (AUD), including the findings of the project, in a user-friendly form for healthcare providers. Healthcare providers are often not knowledgeable about the epidemiology of heavy drinking and AUD and the benefits of non-abstinent drinking reduction. Providing this knowledge to them may help them do improved screening and brief interventions with their patients. Therefore, Aim 2 of this administrative supplement is to prepare a document for healthcare providers that summarizes accurate knowledge about the epidemiology of heavy drinking and alcohol use disorders in a manner that will be easy for the healthcare providers to understand and use. This work will also involve unanticipated costs.

项目摘要 在该项目中，“饮酒水平（暴饮暴食）和酒精后果：使用国家数据来识别 临床试验终点”（R01AA025309），流行病学数据已用于研究 大量的饮酒指标，出现酒精依赖和其他饮酒后果的风险。大部分工作 对于这项研究，集中于非属于饮酒的饮酒是否改善了个人的感受和功能 在广泛的域中。在该项目中，减少饮酒的主要是全世界衡量的 卫生组织（WHO）风险饮酒水平：非常高风险，高风险，中度风险和低风险。这些 表示每天消耗的乙醇的性别平均量。健康结果已经涵盖了 广泛的域，包括酒精依赖（发生，持久性），功能受损，肝脏 疾病，审计-C筛查评分，药物使用障碍，抑郁/焦虑症和心血管疾病 疾病。该项目还促进了解决有关谁风险饮酒水平的类似问题的论文 在随机临床试验的治疗数据中。但是，该研究不包括谁风险的关系 饮酒水平到其他重要变量，这些变量通常与饮酒水平高度相关，也与 结果已经分析。特别是，这些其他变量包括对酒精的耐受性。家史 饮酒障碍；和性少数群体地位。此外，没有关于是否体验的信息 作为性少数群体成员的歧视使性少数群体地位的关系与 谁冒饮酒水平的风险。因此，本行政补充的目标1是进行这些额外的 分析谁风险饮酒水平和容忍度，酒精使用障碍的家族史以及性 少数群体状况将涉及意外成本。此外，不存在总结大量的文件 有关大量饮酒和酒精使用障碍的流行病学的信息（AUD），包括 项目，用于医疗保健提供者的用户友好形式。医疗保健提供者通常对 大量饮酒和aud的流行病学以及非属于饮酒的好处。提供这个 对他们的知识可能会帮助他们改善与患者的筛查和简短干预。所以， 该行政补充的目标2是为医疗保健提供者准备文件 关于重饮酒和酒精使用障碍的流行病学的准确知识以某种方式 医疗保健提供者可以轻松理解和使用。这项工作还将涉及意外成本。

项目成果

Heavy drinking among individuals with HIV: who drinks despite knowledge of the risk?

• DOI: 10.1080/09540121.2017.1382676
• 发表时间: 2018-05
• 期刊: AIDS care
• 影响因子: 1.7
• 作者: Elliott JC;Stohl M;Hasin DS
• 通讯作者: Hasin DS

Stability of Drinking Reductions and Long-term Functioning Among Patients with Alcohol Use Disorder.

• DOI: 10.1007/s11606-020-06331-x
• 发表时间: 2021-03
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Witkiewitz K;Kranzler HR;Hallgren KA;Hasin DS;Aldridge AP;Zarkin GA;Mann KF;O'Malley SS;Anton RF
• 通讯作者: Anton RF

The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001-2002 and 2012-2013.

• DOI: 10.1176/appi.ajp.2020.20050610
• 发表时间: 2021-06
• 期刊: The American journal of psychiatry
• 作者: Shmulewitz D;Aharonovich E;Witkiewitz K;Anton RF;Kranzler HR;Scodes J;Mann KF;Wall MM;Hasin D;Alcohol Clinical Trials Initiative (ACTIVE Group)
• 通讯作者: Alcohol Clinical Trials Initiative (ACTIVE Group)

The Relationship Between Reductions in WHO Risk Drinking Levels During Treatment and Subsequent Healthcare Costs for the ACTIVE Workgroup.

• DOI: 10.1097/adm.0000000000000925
• 发表时间: 2022-07-01
• 期刊: Journal of addiction medicine
• 影响因子: 5.5

World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom.

• DOI: 10.1111/add.15011
• 发表时间: 2020-09
• 期刊: Addiction (Abingdon, England)
• 作者: Witkiewitz K;Heather N;Falk DE;Litten RZ;Hasin DS;Kranzler HR;Mann KF;O'Malley SS;Anton RF
• 通讯作者: Anton RF