Impact of Medical and Recreational Marijuana Laws On Cannabis, Opioids And Psychiatric Medications: National Study of VA Patients, 2000 - 2024

医用和娱乐大麻法对大麻、阿片类药物和精神药物的影响：2000 年至 2024 年退伍军人事务部患者的全国研究

• 批准号: 10612385
• 负责人: DEBORAH S HASIN
• 金额: $ 74.64万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612385
• 关键词: Address; Adult; Affect; Age; Alcohol consumption; Alcohols; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Anxiety Disorders; Area; Attention; Behavior; Cannabis; Cannabis policy; Caring; Cessation of life; Characteristics; Computerized Medical Record; Data; Data Set; Depressive disorder; Diagnosis; Disease; Drug Prescriptions; Economic Factors; Epidemiology; Ethnic Origin; General Population; Health; Health Professional; Healthcare Systems; Impairment; Individual; Internal Medicine; Justice; Knowledge; Laws; Left; Link; Literature; Low income; Medical; Medical Marijuana; Medicare; Mental Depression; Mental disorders; Methods; Modeling; Modification; National Institute of Drug Abuse; Opioid; Outcome; Outcome Study; Overdose; Pain; Patients; Pharmaceutical Preparations; Policies; Policy Maker; Population; Post-Traumatic Stress Disorders; Prevalence; Public Health; Race; Recreation; Research; Research Personnel; Resources; Risk Factors; Symptoms; Testing; Text; Time; Tobacco; Tobacco use; United States Department of Veterans Affairs; Variant; Veterans Health Administration; Vulnerable Populations; addiction; adverse outcome; chronic pain; chronic painful condition; clinical practice; clinical risk; demographics; design; effective therapy; federal policy; high risk; human old age (65+); hypnotic; indexing; male; marijuana use; marijuana use disorder; medical examination; multilevel analysis; opioid epidemic; opioid policy; opioid use; opioid use disorder; overdose death; prescription opioid; public health priorities; sedative; sex; trend

Thirty states now have medical marijuana laws (MML), 9 have recreational marijuana laws (RML), and many more states are considering such laws. The health effects of cannabis laws are controversial; understanding them is a major public health and NIDA priority (PA-17-135). Thus far, only 3 studies of adults (2 of them ours; Hasin et al., 2017, Martins et al., 2016) used multi-level modeling to examine MML effects on cannabis outcomes with individual data. These studies suggested post-MML increases in cannabis use and Cannabis Use Disorder (CUD). However, they left many questions unanswered, including whether MML have stronger effects in those with key vulnerability factors (chronic pain, psychiatric disorders). In addition, soaring rates of opioid prescriptions and overdoses have led to calls for MML as part of the solution to the US opioid crisis, but most MML-opioid studies are ecological (a weak design to study individual behavior), and results from individual-level studies leave the evidence unclear. Ecological studies also suggest that through cannabis substitution, MML reduce medication prescriptions for common psychiatric disorders (e.g., PTSD, depression), but no individual-level studies of this have been conducted. Importantly, RML effects are almost entirely unknown, a major gap in knowledge. In Veterans Administration (VA) patients, CUD prevalence has doubled since 2002, and in those age ≥35, is 2-6 times higher than in the general population. VA patients also have high rates of opioid prescriptions, overdoses, and of chronic pain and psychiatric disorders that may increase their vulnerability to adverse MML and RML effects. They thus are a large, vulnerable population in whom MML and RML effects are unknown. We will investigate MML and RML effects utilizing a major resource, the individual data from the VA Electronic Medical Record, available since 2000 from the ~5,000,000 patients served each year by the VA healthcare system. We will create yearly EMR datasets, and merge this with National Death Index data, Medicare data (for those age ≥65) and state-year MML and RML variables that we will create. Using multi-level models and difference-in-difference tests, we will examine MML and RML effects on three main outcomes: cannabis (use, CUD), opioids (prescriptions, fatal and non-fatal overdoses, opioid use disorders), and psychotropic medication prescriptions (antidepressants, anxiolytics, sedatives/hypnotics). Importantly, we will determine if pain, psychiatric disorders or demographics (sex, age, race/ethnicity) modify MML/RML effects. We will also examine specific MML/RML provisions, time lags, and breakpoints in trends reflecting federal policy changes. Analyses will incorporate individual- and state-level confounders, e.g., state norms, economic factors. We will also explore alcohol and tobacco outcomes. The research team includes substance epidemiology/policy experts and VA addiction and internal medicine experts. Findings will be disseminated to clinicians and policy-makers. Determining MML/RML effects in VA patients will make a major contribution to the limited adult literature on MML/RML, contributing to knowledge that will inform policy and the care of individuals with vulnerability factors.

现在有30个州拥有医用大麻法（MML），9个州有休闲大麻法（RML），许多法律 越来越多的州正在考虑此类法律。大麻法的健康影响是有争议的。理解 他们是主要的公共卫生和NIDA优先事项（PA-17-135）。远处只有3项成人研究（其中2个我们自己； Hasin等人，2017年，Martins等，2016）使用多层建模来检查MML对大麻结果的影响 与个别数据。这些研究表明，MML大麻使用和大麻使用障碍增加 （cud）。但是，他们留下了许多问题，包括MML是否对这些问题产生更大的影响 具有关键脆弱性因素（慢性疼痛，精神疾病）。此外，阿片类药物处方的速度高涨 过量服用导致呼吁MML作为美国阿片类药物危机解决方案的一部分，但大多数MML-阿片类药物 研究是生态的（研究个体行为的薄弱设计），并且来自个人水平研究的结果离开 证据不清楚。生态研究还表明，通过大麻替代，MML减少 常见精神疾病的药物处方（例如，PTSD，抑郁症），但没有个人级别 已经进行了研究。重要的是，RML效应几乎完全未知，这是一个主要差距 知识。在退伍军人管理（VA）患者中，自2002年以来，CUD患病率已翻了一番 年龄≥35岁，比普通人群高2-6倍。 VA患者的阿片类药物率也很高 处方，服药过量以及慢性疼痛和精神疾病可能会增加其脆弱性 不良MML和RML效应。因此，他们是一个脆弱的人群，MML和RML效应是 未知。我们将使用主要资源（来自VA的个体数据）研究MML和RML效应 电子病历，自2000年以来可从每年由VA服务的约5,000,000名患者获得 医疗保健系统。我们将创建年度EMR数据集，并将其与国家死亡指数数据，Medicare合并 我们将创建的数据（对于那些年龄≥65岁）和州年度MML和RML变量。使用多层模型 和差异测试，我们将检查MML和RML对三个主要结果的影响：大麻 （使用，cud），oioid（处方，致命和非致命性过量，OIOID使用障碍）和精神疾病 药物处方（抗抑郁药，抗焦虑药，镇静剂/催眠药）。重要的是，我们将确定是否 疼痛，精神疾病或人口统计学（性别，年龄，种族/种族）修改MML/RML效应。我们也会 检查反映联邦政策变化的趋势中的特定MML/RML规定，时间滞后和断点。 分析将纳入个人和州级的混杂因素，例如州规范，经济因素。我们将 还可以探索酒精和烟草结果。研究小组包括物质流行病学/政策专家 以及VA成瘾和内科专家。调查结果将传播给临床医生和决策者。 确定VA患者的MML/RML效应将为成人有限文献做出重大贡献 MML/RML，有助于知道这将为具有脆弱性因素的个人提供信息。

项目成果

Correction to Lancet Psychiatry 10: 877-86.

《柳叶刀精神病学》10 更正：877-86。

• DOI: 10.1016/s2215-0366(23)00362-0
• 发表时间: 2023
• 期刊: The lancet. Psychiatry

Prevalence and Correlates of Cannabis Use and Cannabis Use Disorder Among U.S. Veterans: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III).

• DOI: 10.1176/appi.ajp.2021.20081202
• 发表时间: 2022-01
• 期刊: The American journal of psychiatry
• 作者: Browne KC;Stohl M;Bohnert KM;Saxon AJ;Fink DS;Olfson M;Cerda M;Sherman S;Gradus JL;Martins SS;Hasin DS
• 通讯作者: Hasin DS

Substance, use in relation to COVID-19: A scoping review.

• DOI: 10.1016/j.addbeh.2021.107213
• 发表时间: 2022-04
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Kumar N;Janmohamed K;Nyhan K;Martins SS;Cerda M;Hasin D;Scott J;Sarpong Frimpong A;Pates R;Ghandour LA;Wazaify M;Khoshnood K
• 通讯作者: Khoshnood K

Trends over time in adult cannabis use: A review of recent findings.

• DOI: 10.1016/j.copsyc.2021.03.005
• 发表时间: 2021-04
• 期刊: Current opinion in psychology
• 影响因子: 5.9
• 作者: Hasin D;Walsh C
• 通讯作者: Walsh C

Implications of Medical and Recreational Marijuana Laws for Neuroscience Research: a Review.

• DOI: 10.1007/s40473-020-00222-5
• 发表时间: 2020-12
• 期刊: Current behavioral neuroscience reports
• 影响因子: 1.7
• 作者: Hasin DS;Aharonovich E
• 通讯作者: Aharonovich E