Stress and Resilience in the VIP

VIP 的压力和弹性

• 批准号: 10726451
• 负责人: OANH L MEYER
• 金额: $ 40.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10726451
• 关键词: Acculturation; Address; Administrative Supplement; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Asian Americans; Attenuated; Biological Markers; Blood; C-reactive protein; California; Cardiovascular Diseases; Cardiovascular system; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collection; Communities; Complement; County; Data; Data Collection; Data Set; Dementia; Development; Disease; Disparity population; Elderly; Ethnic Population; Exposure to; Funding; Goals; Grant; Human Resources; Immigration; Impaired cognition; Individual; Knowledge; Latino; Life; Life Cycle Stages; Lipids; Longitudinal Studies; Measures; Mental Depression; Modeling; Natural experiment; Outcome; Participant; Patient Self-Report; Pattern; Population; Post-Traumatic Stress Disorders; Questionnaires; Race; Reporting; Research; Resources; Risk; Risk Factors; Role; San Francisco; Stress; Time; Trauma; Vietnamese; Visit; War; aged; cardiovascular disorder risk; cardiovascular health; cognitive function; cohort; dementia risk; early life adversity; experience; fasting glucose; inflammatory marker; innovation; insight; low socioeconomic status; migration; mild cognitive impairment; parent grant; perceived stress; programs; racial minority population; resilience; resilience factor; social culture; sociocultural determinant; trauma exposure

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the 4th largest Asian American group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, stress, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this supplement application, Stress and Resilience in the VIP (parent grant: Vietnamese Insights into Cognitive Aging Program (VIP), R01AG067541), we will build on this unprecedented cohort study by collecting additional and innovative data. The overall goal of the parent grant is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. For this supplement, we propose the following: Aim 1: Obtain measures of stress and resilience in VIP participants at their Time 2 visit. We will add two additional measures not yet captured in the grant but are important within the context of cognitive aging for Vietnamese Americans– perceived stress and resilience, and hs-CRP will be added to the blood draw (N = 540). Aim 2. Examine the associations between stress, trauma, and adversity. We hypothesize that those with increased levels of perceived stress and hs-CRP at Time 2 will have reported higher levels of trauma and adversity at the Time 1 visit. Aim 3. Examine the associations between new measures and cognition. We hypothesize that those with elevated levels of perceived stress and hs- CRP will have lower cross-sectional cognition scores, and this relationship will be attenuated by higher resilience scores. This proposal contributes new research to an unmatched longitudinal study whose findings will lead to a better understanding of cognitive aging and mechanisms of disease in an understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.

亚裔美国人是美国增长最快的种族少数群体，但缺乏 研究他们对阿尔茨海默氏病和相关痴呆症（ADRD）的认知衰老和风险的研究。 对于美国第四大亚裔美国人群体而言，越南美国人尤其如此 越南美国人因早期逆境和创伤，抑郁症而遭受不佳的痛苦 压力和低社会经济地位（SES），所有这些都可能增加认知障碍的风险 和痴呆的发展。 创伤，压力，多样化的一次语和移民模式）提供了一个独特的机会 检查早期的生活因素和社会文化多样性如何影响认知结果 VIP中的应用，压力和韧性（父母赠款：越南人对认知衰老的见解 计划（VIP），R01AG067541），我们将通过收集未经预科的同类研究来建立 其他创新数据。 社区中轻度认知障碍和痴呆症，并确定ADRD风险和弹性因素 在该补充的研究群体中，我们提出以下方面：目标1： VIP参与者的压力和韧性在他们的时间2访问中。 尚未在赠款中捕获，但在越南认知衰老的背景下很重要 美国人感知到的压力和韧性，HS-CRP将被添加到抽血中（n = 540）。 目标2.我们假设压力，创伤和逆境之间的关联 那些在时间2时感知压力和HS-CRP水平增加的人将报告更高的水平 1次访问时创伤和逆境。 措施和认知。 CRP的横断面认知评分较低 弹性分数。 发现将使人们更好地理解对疾病的认知衰老和疾病机制的认知 研究了群体，但也对促进我们对社会文化的了解的更广泛的含义 以及其他人群认知衰老的早期生活贡献。