Vietnamese Insights into Cognitive Aging Program (VIP)

越南认知衰老洞察计划（VIP）

• 批准号: 10551834
• 负责人: OANH L MEYER
• 金额: $ 145.69万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10551834
• 关键词: Acculturation; Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Asian Americans; Asian population; Attenuated; Biological; Black Populations; California; Cardiovascular Diseases; Childhood; Chinese; Cognition; Cognitive; Cognitive aging; Communities; Data; Dementia; Development; Disease; Disparity population; English Language; Enrollment; Ethnic Origin; Ethnic Population; Exposure to; Family Caregiver; Goals; Health; Health Disparities Research; High Prevalence; Immigrant; Immigration; Impaired cognition; Impairment; Individual; Intervention; Knowledge; Latino Population; Life; Life Cycle Stages; Longitudinal Studies; Mediating; Mental Depression; Modeling; Neighborhoods; Not Hispanic or Latino; Outcome; Pathway interactions; Pattern; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention; Process; Race; Research; Risk; Risk Factors; Role; San Francisco; Social support; Socioeconomic Status; Subgroup; Trauma; Underserved Population; United States; Universities; Vietnamese; War; Woman; Work; aged; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cognitive function; cohesion; cohort; community partnership; dementia risk; early life adversity; ethnic diversity; experience; health disparity; innovation; insight; low socioeconomic status; men; mild cognitive impairment; novel; physical inactivity; post-traumatic stress; programs; prospective; protective factors; public health relevance; racial diversity; racial minority population; racial population; recruit; resilience; resilience factor; sex; smoking prevalence; social culture; social factors; southeast Asian; supportive environment; theories; trauma exposure

Asian Americans are the fastest growing racial minority group in the U.S and yet there is a dearth of research on their cognitive aging and risks for Alzheimer's disease and related dementias (ADRD). This is especially true for Vietnamese Americans, the largest Southeast Asian group in the U.S. Vietnamese Americans suffer disproportionately from early life adversity and trauma, depression, and low socioeconomic status (SES), all of which may increase risk for cognitive impairment and development of dementia. The specific sociocultural context of this group (i.e., high exposure to trauma, post-traumatic stress, diverse acculturation and immigration patterns) provides a unique opportunity to examine how early life factors and sociocultural diversity impact cognitive outcomes. In this R01 application, Vietnamese Insights into Cognitive Aging Program (VIP), we will develop an unprecedented longitudinal study of older Vietnamese Americans to begin addressing the dearth of cognitive aging research in this population. The overall goal is to obtain preliminary estimates of mild cognitive impairment and dementia in the community and identify ADRD risk and resilience factors in this understudied group. Using the NIA health disparities research framework as a model, we propose the following: Aim 1: Characterize longitudinal cognitive function and ADRD risk in a community-based cohort of 540 older Vietnamese aged 65+ living in Northern California. Aim 2a: Examine the role of adversity and trauma on ADRD risk in older Vietnamese. Aim 2b: Evaluate the influence of current sociocontextual factors on ADRD risk in older Vietnamese. Aim 3: Determine the role of cardiovascular disease and health risk factors on cognition in older Vietnamese. In the process of studying these important risk and protective factors, we will engage a population that is severely missing from aging research and contribute to theory on the role of adversity, trauma, and sociocultural diversity on dementia risk. This study will leverage an older Vietnamese population with which we already have strong community partnerships to create an unmatched longitudinal study. Findings will lead to a better understanding of cognitive aging and mechanisms of disease in this understudied group but also have broader implications for advancing our knowledge of the sociocultural and early life contributions to cognitive aging in other populations.

亚裔美国人是美国增长最快的少数族裔群体，但缺乏研究 认知老化以及阿尔茨海默病和相关痴呆症 (ADRD) 的风险。这尤其是 对于美国最大的东南亚群体越南裔美国人来说确实如此 越南裔美国人遭受苦难 不成比例地由于早年生活的逆境和创伤、抑郁和低社会经济地位（SES），所有这些 这可能会增加认知障碍和痴呆症的风险。特定的社会文化 该群体的背景（即高度暴露于创伤、创伤后应激、多样化的文化适应和 移民模式）提供了一个独特的机会来研究早期生活因素和社会文化多样性如何 影响认知结果。在这个 R01 应用程序中，越南认知老化计划 (VIP)， 我们将对老年越南裔美国人进行前所未有的纵向研究，以开始解决 缺乏针对这一人群的认知衰老研究。总体目标是获得轻度的初步估计 社区中的认知障碍和痴呆症，并确定 ADRD 风险和复原力因素 待研究组。以 NIA 健康差异研究框架为模型，我们提出 目标 1：描述基于社区的队列中的纵向认知功能和 ADRD 风险 540 名 65 岁以上越南老人居住在北加州。目标 2a：检查逆境和创伤的作用 越南老年人 ADRD 风险。目标 2b：评估当前社会背景因素对 ADRD 的影响 老年越南人的风险。目标 3：确定心血管疾病和健康危险因素对健康的影响 老越南语的认知。在研究这些重要的风险和保护因素的过程中，我们将 让老龄化研究中严重缺失的人群参与其中，并为老龄化作用的理论做出贡献 逆境、创伤和社会文化多样性对痴呆风险的影响。这项研究将利用年长的越南人 我们已经与他们建立了强有力的社区伙伴关系，以创建无与伦比的纵向人口 学习。研究结果将有助于更好地了解认知衰老和疾病机制 未被充分研究的群体，而且对于增进我们对社会文化和社会的了解也具有更广泛的影响 早期生活对其他人群认知衰老的贡献。