Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)

血管性认知障碍和痴呆 (VCID) 中的脑小血管成像

• 批准号: 10745164
• 负责人: Xuejuan Jiang
• 金额: $ 248.77万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745164
• 关键词: 3-Dimensional; Acceleration; African American; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian; Asian Americans; Atrophic; Behavioral; Blood; Blood Vessels; Blood capillaries; Brain; Caucasians; Cerebral small vessel disease; Cerebrum; Clinical; Cognitive; Data; Dementia; Development; Diffusion; Early Intervention; Enrollment; Evaluation; Goals; Guidelines; Head; Image; Image Analysis; Imaging Device; Imaging technology; Knowledge; Lacunar Infarctions; Latinx; Lesion; Longitudinal cohort; Los Angeles; Magnetic Resonance Imaging; Maps; Mediating; Morphology; Motion; Neuropsychology; Participant; Pathway Analysis; Perforating Artery; Perfusion; Physics; Physiological; Population; Prevention; Protocols documentation; Public Health; Research; Research Priority; Resolution; Resources; Risk; Speed; Stroke; Surrogate Markers; Techniques; Testing; Three-dimensional analysis; Training; Visit; Visualization; aged; analysis pipeline; arterial spin labeling; arteriole; behavioral phenotyping; biomedical imaging; cerebral microbleeds; cerebrovascular; clinical diagnosis; cohort; deep learning algorithm; density; disease phenotype; executive function; health disparity; high risk; imaging biomarker; improved; in vivo imaging; longitudinal analysis; mild cognitive impairment; mixed dementia; multi-ethnic; multidisciplinary; novel; potential biomarker; racial diversity; recruit; symposium; vascular cognitive impairment and dementia; venule; white matter

Project Summary/Abstract Vascular contributions to cognitive impairment and dementia (VCID) is becoming increasingly recognized as an important cause of dementia. Cerebral small vessel disease (cSVD) is the most common vascular cause of dementia, a major contributor to mixed dementia, and the cause of about one fifth of all strokes worldwide. However, the underlying mechanisms of cSVD remain poorly understood. The large knowledge gap in cSVD is partly because cerebral small vessels, including arterioles, capillaries and venules, are inaccessible to existing in vivo imaging technologies. During the past few years, our group has spearheaded the development of a new high-resolution black-blood MRI technique for the visualization, segmentation and quantification of cerebral small vessels including lenticulostriate and superficial perforating arteries and venules. This technique offers an isotropic ~0.5mm spatial resolution, adequate flow suppression for small vessels due to the long echo train, and near whole-brain coverage in ~10min at clinical field strength of 3T. We further developed a comprehensive 3D analysis pipeline for quantifying the morphology and density of cerebral small vessels with sizes on the order of a few hundred microns. In addition, we have a longstanding track record in developing and applying arterial spin labeling (ASL) techniques for quantifying microvascular perfusion – a key physiological parameter and potential biomarker for cSVD. Our preliminary data demonstrated expected changes in small vessel morphology and density as well as microvascular perfusion with aging, vascular risks and mild cognitive impairment (MCI), supporting the use of metrics of small vessel morphology/density and microvascular perfusion as imaging markers of cSVD and VCID. The primary goals of this project are to further optimize the acquisition protocol and analysis pipeline for mapping and quantifying cerebral small vessels using black-blood and ASL MRI at 3T, and to systematically evaluate metrics of small vessel morphology/density and perfusion as imaging biomarkers of VCID in a multiethnic longitudinal cohort of 200 subjects that are enriched for small vessel VCID. In particular, our study will enroll a cohort of 50 Asian Americans who are among the fastest growing populations in the US but are highly underrepresented in ADRD research. This project is expected to result in a powerful suite of imaging tools for comprehensive characterization of the morphology and function of cerebral small vessels, as well as to fill in the important gap in health disparities of Asian Americans in ADRD research.

项目摘要/摘要 对认知障碍和痴呆（VCID）的血管贡献越来越被认为是 痴呆症的重要原因。脑小血管疾病（CSVD）是最常见的血管原因 痴呆症是混合痴呆症的主要贡献者，以及全球所有中风的五分之一的原因。 但是，CSVD的基本机制仍然很少理解。 CSVD中的较大知识差距是 部分是因为包括动脉，毛细血管和静脉包括包括动脉，毛细血管和静脉的脑小血管无法使用 体内成像技术。在过去的几年中，我们的小组率先开发了一个新的 高分辨率黑血MRI技术，用于可视化，分割和数量大脑 小血管在内，包括扁豆和表面穿孔的动脉和静脉。该技术提供 各向同性〜0.5mm的空间分辨率，由于长回声列而引起的小血管的足够流动抑制， 在3T的临床场强度下，在〜10分钟内，全脑覆盖范围接近。我们进一步开发了 全面的3D分析管道，用于量化脑小血管的形态和密度 大小按几百微米为单位。此外，我们在发展方面还有很长的记录 并应用动脉自旋标记（ASL）技术来量化微血管灌注 - 关键 CSVD的物理参数和潜在的生物标志物。我们的初步数据预期 小血管形态和密度的变化以及随老化，血管风险的微血管灌注的变化 和轻度认知障碍（MCI），支持使用小血管形态/密度的指标 微血管灌注是CSVD和VCID的成像标记。该项目的主要目标是进一步 优化用于映射和量化脑小型视频的采集协议和分析管道 在3T处使用黑血和ASL MRI，并系统地评估小容器的指标 在200个纵向队列中，形态/密度和灌注为VCID的成像生物标志物 富含小血管VCID的受试者。特别是，我们的研究将招募50个亚洲人 美国人是美国增长最快但在ADRD中的人数不足的美国人 研究。预计该项目将为全面提供一套强大的成像工具 脑小血管的形态和功能的表征，以及填补重要的空白 在ADRD研究中亚裔美国人的健康分布中。