Exposure to Per- and Polyfluoroalkyl Substances and Child Lung Function

接触全氟烷基和多氟烷基物质与儿童肺功能

• 批准号: 10739012
• 负责人: Jennifer Ann-Marie Oliver
• 金额: $ 0.25万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10739012
• 关键词: Adolescence; Adult; Adverse effects; Affect; Alveolar; Animals; Birth; Blood; Chemicals; Child; Childhood; Chronic Disease; Cohort Studies; Complex; Development; Environment; Exposure to; Growth and Development function; Human body; Impairment; Individual; Industrial Product; Intervention; Life; Lung; Massachusetts; Measures; Mothers; Pathway interactions; Poly-fluoroalkyl substances; Population; Predisposition; Premature Mortality; Regulation; Risk Reduction; consumer product; early onset; epidemiology study; lung development; lung health; lung maturation; prenatal; prenatal exposure; pulmonary function; recruit; surfactant function; Adolescence; Adult; Adverse effects; Affect; Alveolar; Animals; Birth; Blood; Chemicals; Child; Childhood; Chronic Disease; Cohort Studies; Complex; Development; Environment; Exposure to; Growth and Development function; Human body; Impairment; Individual; Industrial Product; Intervention; Life; Lung; Massachusetts; Measures; Mothers; Pathway interactions; Poly-fluoroalkyl substances; Population; Predisposition; Premature Mortality; Regulation; Risk Reduction; consumer product; early onset; epidemiology study; lung development; lung health; lung maturation; prenatal; prenatal exposure; pulmonary function; recruit; surfactant function

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are a group of persistent and bioaccumulative chemicals used in a large number of industrial and consumer products that have been measured in blood of more than 97% of the population above 6 years in nationally representative studies. PFAS are commonly assessed as individual chemicals, but exist as diverse and complex chemical mixtures of known and unknown compounds in the environment and human body. Due to rapid lung development and growth that occurs during the prenatal period and childhood, these developmental periods may be particularly susceptible to the adverse effects of PFAS on lung function. Impaired lung function in childhood is associated with impaired lung function in adulthood, which in turn is associated with early onset of chronic diseases and premature mortality from all causes. Animal studies suggest PFAS adversely affect lung maturation, surfactant function, and alveolar integrity, but there are limited epidemiological studies exploring the association between PFAS and lung function in children. The findings from the previous epidemiological studies are limited, inconclusive, and lack longitudinal assessment. Our study proposes to investigate the effects of PFAS and PFAS mixtures on children’s lung function in Project Viva, an ongoing pre-birth cohort study of 1116 mother-child pairs recruited in Massachusetts between 1999 and 2002. Specifically, we will 1) evaluate the association between prenatal exposure to PFAS and PFAS mixtures and lung function in mid-childhood, and 2) assess the association between mid-childhood PFAS and PFAS mixtures and lung function in mid-childhood and adolescence. To our knowledge, this will be the first study to assess the effects of PFAS mixtures on lung function in children, and the longitudinal effects of these chemicals on lung health. As we seek to identify potential causal pathways for the impact of PFAS on lung function during developmental periods, our findings may support PFAS mitigation and regulation, and the development of targeted interventions to reduce the risk of lung illness later in life.

项目摘要/摘要 每种和多氟烷基物质（PFA）是一组持续和生物蓄积的化学物质 大量的工业和消费产品已在血液中衡量的97％以上 在国家代表性研究中超过6年的人口。 PFA通常被评估为个体 化学物质，但作为潜水员和复杂的化学混合物的存在 环境和人体。由于肺部的快速发育和生长在产前期间发生 和童年，这些发展时期可能特别容易受到PFA对PFA的不利影响的影响 肺功能。儿童期肺功能受损与成年后的肺功能受损有关 反过来又与各种原因的慢性疾病早期发作和过早死亡有关。动物研究 建议PFA不利地影响肺部成熟，生存功能和肺泡完整性，但有限 流行病学研究探讨了儿童PFA与肺功能之间的关联。来自 先前的流行病学研究有限，没有定论且缺乏纵向评估。我们的研究 研究PFA和PFA混合物对儿童肺功能的影响的提议， 在1999年至2002年之间，正在马萨诸塞州招募的1116个母子对的出生前队列研究正在进行。 具体而言，我们将1）评估产前暴露于PFA和PFA的混合物与 肺部的肺功能在中期和2）评估年龄中期PFA和PFA混合物之间的关联 肺部功能在中期和青少年时期。据我们所知，这将是评估评估的第一项研究 PFA混合物对儿童肺功能的影响以及这些化学物质对肺的纵向作用 健康。当我们寻求确定PFA对PFA对肺功能的影响的潜在因果途径时 发育时期，我们的发现可能支持PFAS减轻和监管，以及 有针对性的干预措施，以减少以后生活中肺部疾病的风险。