Developmental effects of antenatal exposure to antipsychotics

产前接触抗精神病药物对发育的影响

基本信息

批准号：
10608542
负责人：
THALIA K ROBAKIS
金额：
$ 63.51万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10608542
关键词：
Adolescence Adverse effects Affect Antipsychotic Agents Auditory Behavior Behavioral Bipolar Disorder Body Size Caring Child Clinical Cognitive Controlled Study Data Data Set Development Diagnosis Disease Dopamine Dopamine D2 Receptor Electroencephalography Emotional Equilibrium Exposure to Female of child bearing age Fetal Development Fetus Frequencies Fright Gestational Diabetes Goals Growth Hemorrhage Home visitation Infant Infant Development Interneurons Interview Investigation Lactation Longitudinal cohort study Measurable Measures Mediating Mental Depression Mental disorders Mood stabilizers Moods Mothers Motor Neonatal Netherlands Observational Study Outcome Outcome Study Perinatal Pharmaceutical Preparations Pilot Projects Placenta Population Postpartum Period Pre-Eclampsia Prefrontal Cortex Pregnancy Pregnancy Complications Pregnant Women Prevalence Proliferating Psychiatry Psychoses Psychotic Disorders Pyramidal Cells Relapse Risk Serum Short-Term Memory Signal Transduction Social Functioning Syndrome Testing Time Toddler Woman adverse pregnancy outcome antenatal anxiety symptoms behavior observation comparison group course development emerging adult in utero infant outcome male neonatal outcome neonate nerve stem cell neural neurobehavioral non-affective psychoses obstetric outcomes offspring pregnant prenatal exposure prospective psychosocial psychotic recruit risk/benefit ratio sensory gating severe mental illness sex spatial memory

项目摘要

Project Summary/Abstract Antipsychotics are a class of commonly used medications that are used for multiple indications within psychiatry, including psychosis, mood stabilization, and augmentation for depression. The use of antipsychotics among pregnant and lactating women has increased in frequency in recent years. However, their efficacy has not been directly tested in this population, and many unanswered questions remain about the potential effects of antipsychotics on the development of the fetus, neonate, and infant. We propose to conduct a prospective observational study of maternal psychiatric course and infant development among women with severe mental illness, comparing women treated with antipsychotics to women treated with other medications or without medication. The primary study outcomes will be psychiatric relapse in the mother, EEG abnormalities in the infant at 6 months, and behavioral and psychosocial outcomes at 18 months. We hope to determine whether antipsychotics are effective for pregnant women with severe mental illness and whether they have any measurable effects on infant development. This information will help women with severe mental illness make informed decisions about their care in pregnancy.

项目概要/摘要抗精神病药是一类常用药物，可用于多种疾病精神病学的适应症，包括精神病、情绪稳定和增强沮丧。孕妇和哺乳期妇女抗精神病药物的使用有所增加近年来出现频率。然而，它们的功效尚未在本研究中得到直接测试。人口，并且关于潜在影响的许多悬而未决的问题仍然存在抗精神病药对胎儿、新生儿和婴儿发育的影响。我们建议对孕产妇精神病学过程进行前瞻性观察研究以及患有严重精神疾病的妇女的婴儿发育情况，比较接受治疗的妇女接受抗精神病药物治疗的女性接受其他药物治疗或不接受药物治疗。初级研究结果将是母亲精神疾病复发，婴儿 6 岁时脑电图异常个月，以及 18 个月时的行为和心理社会结果。我们希望确定抗精神病药物对患有严重精神疾病的孕妇是否有效？它们对婴儿发育有任何可测量的影响。这些信息将帮助女性严重精神疾病对其怀孕期间的护理做出明智的决定。