Exposure to Per- and Polyfluoroalkyl Substances and Child Lung Function

接触全氟烷基和多氟烷基物质与儿童肺功能

基本信息

批准号：
10658859
负责人：
Jennifer Ann-Marie Oliver
金额：
$ 2.91万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10658859
关键词：
6 year old Address Adolescence Adolescent Adult Adverse effects Affect Airway Resistance Alveolar Animals Asthma Biometry Birth Blood Chemical Exposure Chemicals Child Childhood Chronic Disease Chronic Obstructive Pulmonary Disease Cohort Studies Complex Data Development Early Intervention Environment Environmental Exposure Epidemiology Exposure to First Pregnancy Trimester Forced expiratory volume function Funding Future Goals Growth Growth and Development function Health Human body Impairment Individual Industrial Product Intervention Life Life Cycle Stages Literature Longevity Low Birth Weight Infant Lung Massachusetts Measurement Measures Medicine Mentorship Mothers National Institute of Environmental Health Sciences Organic Chemicals Outcome Pathway interactions Pediatric epidemiology Perinatal Epidemiology Plasma Poly-fluoroalkyl substances Population Predisposition Pregnancy Pregnant Women Premature Mortality Prevention strategy Public Health Pulmonology Quality of life Regulation Research Risk Reduction Statistical Methods Time Toxic effect Training Training and Education United States National Institutes of Health Vaccines Vital capacity Wheezing asthmatic career cohort consumer product critical period early adolescence early childhood early life exposure early onset environmental chemical epidemiology study health communication improved in utero lung development lung health lung maturation lung volume prenatal prenatal exposure pulmonary function recruit respiratory respiratory health response surfactant function

项目摘要

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are a group of persistent and bioaccumulative chemicals used in a large number of industrial and consumer products that have been measured in blood of more than 97% of the population above 6 years in nationally representative studies. PFAS are commonly assessed as individual chemicals, but exist as diverse and complex chemical mixtures of known and unknown compounds in the environment and human body. Due to rapid lung development and growth that occurs during the prenatal period and childhood, these developmental periods may be particularly susceptible to the adverse effects of PFAS on lung function. Impaired lung function in childhood is associated with impaired lung function in adulthood, which in turn is associated with early onset of chronic diseases and premature mortality from all causes. Animal studies suggest PFAS adversely affect lung maturation, surfactant function, and alveolar integrity, but there are limited epidemiological studies exploring the association between PFAS and lung function in children. The findings from the previous epidemiological studies are limited, inconclusive, and lack longitudinal assessment. Our study proposes to investigate the effects of PFAS and PFAS mixtures on children’s lung function in Project Viva, an ongoing pre-birth cohort study of 1116 mother-child pairs recruited in Massachusetts between 1999 and 2002. Specifically, we will 1) evaluate the association between prenatal exposure to PFAS and PFAS mixtures and lung function in mid-childhood, and 2) assess the association between mid-childhood PFAS and PFAS mixtures and lung function in mid-childhood and adolescence. To our knowledge, this will be the first study to assess the effects of PFAS mixtures on lung function in children, and the longitudinal effects of these chemicals on lung health. As we seek to identify potential causal pathways for the impact of PFAS on lung function during developmental periods, our findings may support PFAS mitigation and regulation, and the development of targeted interventions to reduce the risk of lung illness later in life.

项目摘要/摘要每种和多氟烷基物质（PFA）是一组持续和生物蓄积的化学物质大量的工业和消费产品已在血液中衡量的97％以上在国家代表性研究中超过6年的人口。 PFA通常被评估为个体化学物质，但作为潜水员和复杂的化学混合物的存在环境和人体。由于肺部的快速发育和生长在产前期间发生和童年，这些发展时期可能特别容易受到PFA对PFA的不利影响的影响肺功能。儿童期肺功能受损与成年后的肺功能受损有关反过来又与各种原因的慢性疾病早期发作和过早死亡有关。动物研究建议PFA不利地影响肺部成熟，生存功能和肺泡完整性，但有限流行病学研究探讨了儿童PFA与肺功能之间的关联。来自先前的流行病学研究有限，没有定论且缺乏纵向评估。我们的研究研究PFA和PFA混合物对儿童肺功能的影响的提议，在1999年至2002年之间，正在马萨诸塞州招募的1116个母子对的出生前队列研究正在进行。具体而言，我们将1）评估产前暴露于PFA和PFA的混合物与肺部的肺功能在中期和2）评估年龄中期PFA和PFA混合物之间的关联肺部功能在中期和青少年时期。据我们所知，这将是评估评估的第一项研究 PFA混合物对儿童肺功能的影响以及这些化学物质对肺的纵向作用健康。当我们寻求确定PFA对PFA对肺功能的影响的潜在因果途径时发育时期，我们的发现可能支持PFAS减轻和监管，以及有针对性的干预措施，以减少以后生活中肺部疾病的风险。