Cross-Species Multidisciplinary Training in Alcohol Research

酒精研究的跨物种多学科培训

• 批准号: 10628897
• 负责人: MICHAEL F MILES
• 金额: $ 38.83万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628897
• 关键词: Training; alcohol research; multidisciplinary

This revised application proposes a new T32 Institutional National Research Service Award with five years of support to fund Cross-Species Multidisciplinary Training in Alcohol Research, comprising four pre-doctoral and two postdoctoral trainees. Virginia Commonwealth University (VCU) has a history of excellence in the alcohol and drug abuse fields, ranking 7th nationally in currently active NIAAA awards (n=36). Major existing research or training funding include: 80 NIDA or NIAAA currently funded projects, NIAAA P50 supported VCU Alcohol Research Center (VCU-ARC), 12 individual F-awards to VCU trainees (7 NIAAA, 5 NIDA), NIDA T32- supported training program now in its 46th year of continuous funding, NIMH T32 training program funded for over 20 years, and a recently funded Medical Scientist Training Program T32. A focal point for alcohol research at VCU is the VCU Alcohol Research Center (VCU-ARC), now in its 12th year of NIAAA support with P50 funding renewed in 2020. VCU-ARC pursues an integrated cross-species program of genetic, genomic, behavioral and molecular studies to identify genes, gene networks and genetic variants contributing to risk and mechanisms of alcohol use disorder (AUD). VCU-ARC and the overall excellence in alcohol research at VCU make this a fertile training environment across multiple VCU departments or institutes. These include: the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) and the Departments of Pharmacology & Toxicology, Human and Molecular Genetics, Psychology, Psychiatry, Internal Medicine and the Program in Neuroscience. The cross-species academic scope will include a 2 year, monthly Foundations of Alcohol Research lecture series, monthly research seminars in VCU ARC, a trainee-led alcohol research journal club, rigorous departmental-specific core courses and advanced electives, a high level of collaboration among mentors to include reciprocal service on thesis committees, multiple excellent seminar series, and required attendance at national or international alcohol research meetings. Multiple active VCU initiatives will increase diversity of trainees, augment retention of under-represented minority faculty and enhance mentor training. Specific major program strengths include: i) broad cross-species expertise of faculty in behavioral pharmacology, psychiatry, genetics, neuroscience, statistics, neuroimaging, data science and psychology; ii) highly productive research environment with accomplished, well-funded faculty; iii) extensive experience and excellent track record of a diverse faculty in training at this level; iv) access to large, informative datasets collected at VCU; v) instruction in responsible conduct of research utilizing an innovative text from a VCU expert in this field; and vi) a unique atmosphere and strong track record at VCU for support of diversity with multiple funded programs for such efforts. This training program thus offers a broad-based, cross-species training in alcohol research in an environment of research excellence and respect for diversity.

此修订后的申请提出了新的 T32 机构国家研究服务奖，为期五年 支持资助酒精研究的跨物种多学科培训，包括四名博士前和 博士后实习生两名。弗吉尼亚联邦大学 (VCU) 在酒精方面拥有卓越的历史 和药物滥用领域，在目前活跃的 NIAAA 奖项中排名全国第七（n=36）。现有主要研究 或培训资金包括：80个NIDA或NIAAA当前资助的项目，NIAAA P50支持的VCU酒精 研究中心 (VCU-ARC)，向 VCU 学员授予 12 项个人 F 奖（7 NIAAA、5 NIDA）、NIDA T32- 支持的培训计划现已连续资助 46 年，NIMH T32 培训计划资助 20 多年来，以及最近资助的医学科学家培训计划 T32。酒精的焦点 VCU 的研究中心是 VCU 酒精研究中心 (VCU-ARC)，现已进入 NIAAA 支持的第 12 个年头 P50 资助于 2020 年更新。VCU-ARC 致力于遗传、基因组、 行为和分子研究，以确定导致风险和风险的基因、基因网络和遗传变异 酒精使用障碍（AUD）的机制。 VCU-ARC 以及 VCU 在酒精研究方面的整体卓越表现 使其成为跨 VCU 多个部门或机构的肥沃培训环境。这些包括： 弗吉尼亚精神病学和行为遗传学研究所 (VIPBG) 以及药理学和 毒理学、人类和分子遗传学、心理学、精神病学、内科医学和项目 神经科学。跨物种学术范围将包括为期 2 年、每月一次的酒精基础课程 研究讲座系列、VCU ARC（一个由实习生主导的酒精研究期刊俱乐部）每月举行的研究研讨会， 严格的部门特定核心课程和高级选修课，高水平的协作 导师包括论文委员会的互惠服务、多个优秀的研讨会系列以及必需的 参加国家或国际酒精研究会议。多个活跃的 VCU 举措将会增加 学员的多样性，增加代表性不足的少数族裔教师的保留率，并加强导师培训。 具体的专业优势包括： i) 行为学领域教师广泛的跨物种专业知识 药理学、精神病学、遗传学、神经科学、统计学、神经影像学、数据科学和心理学；二） 高效的研究环境，拥有才华横溢、资金充足的师资队伍； iii) 丰富的经验和 多元化教师在这一级别的培训中拥有出色的记录； iv) 访问大型、信息丰富的数据集 在 VCU 收集； v) 利用 VCU 的创新文本进行负责任的研究指导 该领域的专家； vi) VCU 独特的氛围和良好的记录支持多样性 为此类努力设立了多个资助计划。因此，该培训计划提供了基础广泛的跨物种 在卓越研究和尊重多样性的环境中进行酒精研究培训。