Administration Core

行政核心

• 批准号: 10628255
• 负责人: Erin L Sutfin
• 金额: $ 38.96万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-03 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628255
• 关键词: Address; Adolescent; Adolescent Development; Aerosols; Affect; Behavior; Benchmarking; Biological Markers; Biometry; Brain; Cancer Center Support Grant; Characteristics; Cigarette; Clinical Trials; Collaborations; Communication; Complex; Dependence; Development; Discipline; Endowment; Ensure; Epidemic; Evaluation; Funding; Generations; Goals; Grant; Health; Health Policy; Lead; Life; Literature; Manuscripts; Measurement; Medicine; Monitor; National Institute of Drug Abuse; Nicotine; Nicotine Dependence; North Carolina; Oncology; Personal Satisfaction; Pharmacology; Physiology; Pilot Projects; Play; Policies; Positioning Attribute; Principal Investigator; Process; Protocols documentation; Psychology; Public Health; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk Assessment; Role; Schools; Science; Science Policy; Services; Social Sciences; System; Tobacco; Toxicology; Travel; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Work; Youth; addiction; adolescent health; brain health; cognitive development; community engagement; data sharing; design; experience; forest; health communication; human subject protection; innovation; interdisciplinary approach; meetings; multidisciplinary; multiple omics; operation; prevent; professor; programs; psychosocial development; recruit; respiratory health; smoking cessation; success; tobacco control; tobacco regulatory science; vaping

ABSTRACT – ADMINISTRATIVE CORE The epidemic of youth vaping is threatening the health and well-being of adolescents. The proposed project (“A Multidisciplinary Assessment of Risks of Vaping in Early Life” - Project MARVEL) takes an integrated multidisciplinary approach to assess the impact of youth vaping on health in collaboration with the system that is most directly impacted by adolescent vaping and is well-positioned to intervene to reduce the potential negative health impact - schools. To achieve this overarching goal, Project MARVEL brings together expertise in adolescent development, addiction, tobacco regulatory science, longitudinal research methods, brain development, respiratory health, biomarkers, multi-omics, biostatistics, community engagement, and health communication. Project MARVEL includes four innovative and integrative projects that will determine the impact of vaping on dependence and well-being (Project 1), brain health and cognitive and psychosocial development (Project 2), and respiratory health (Project 3), and leverage this health information, along with the extant literature to develop health communication messages focused on how vaping affects adolescents’ health and lives now (Project 4). These projects are supported by four cores that provide critical services including: (1) administrative support; (2) biostatistical expertise; (3) facilitation with conducting research with adolescents, including recruitment and retention; and (4) biomarkers of exposure/effect, and measurement of product constituents, generated aerosols. Conducting the type of translational and participatory adolescent research proposed in Project MARVEL is challenging. It requires oversight of large and complex projects and cores, coordination between researchers; facilitation of scientific integration across different disciplines; and the experience required to overcome many practical challenges to the successful implementation of scientific protocols. The Administrative Core was designed to address each of these challenges through three specific aims: 1) Manage operations including administrative, financial, and regulatory functions; 2) Facilitate scientific discussion, and integration; 3) Coordinate dissemination of scientific findings. To address these aims, the Administrative Core will oversee regular meetings, organize travel and reimbursements; provide budgetary oversight for all projects and cores; and oversee human subjects’ protections, registration of clinical trials, and the generation of reports. The Administrative Core will also organize regular discussion of topics related to youth vaping through a monthly scientific seminar and an annual scientific retreat/external advisory board meeting, support the development of scientific presentations, manuscripts, and submissions to the federal docket, and implement policies for data sharing across the three research projects, as well as external to the Program Project. Lastly, the Administrative Core will engage experts to serve on an External Advisory Board to review the immediate and long-term goals of MARVEL, to monitor progress towards these goals, and to provide input on study design study design, interpretation of results, and translational efforts.

摘要 – 行政核心 青少年电子烟的流行正在威胁青少年的健康和福祉该项目提出（“A. 对生命早期电子烟风险的多学科评估”——MARVEL 项目) 与系统合作，采用多学科方法评估青少年吸电子烟对健康的影响 受青少年电子烟影响最直接，并且有能力进行干预以减少潜在的影响 负面健康影响 - 学校 为了实现这一总体目标，Project MARVEL 汇集了专业知识。 青少年发展、成瘾、烟草监管科学、纵向研究方法、大脑 发育、呼吸健康、生物标志物、多组学、生物统计学、社区参与和健康 MARVEL 项目包括四个创新和综合项目，它们将决定 电子烟对依赖性和福祉（项目 1）、大脑健康以及认知和心理社会的影响 发展（项目 2）和呼吸健康（项目 3），并利用这些健康信息以及 现有文献开发健康传播信息，重点关注电子烟如何影响青少年 现在的健康和生活（项目 4）由提供关键服务的四个核心支持。 包括：(1) 行政支持；(2) 生物统计专业知识；(3) 协助开展研究 青少年，包括招募和保留；(4) 暴露/效应的生物标志物以及测量 产品成分，产生的气溶胶，进行青少年的转化和参与。 MARVEL 项目中提出的研究具有挑战性，它需要对大型且复杂的项目进行监督。 核心、研究人员之间的协调；促进不同学科的科学整合； 克服成功实施科学计划的许多实际挑战所需的经验 管理核心旨在通过三个具体的挑战来应对这些挑战。 目标： 1) 管理运营，包括行政、财务和监管职能； 2) 促进科学发展； 3) 协调科学发现的传播 为了实现这些目标， 行政核心将监督定期会议、组织差旅和提供预算报销； 监督所有项目和核心；并监督人类受试者的保护、临床试验的注册，以及 行政核心还将定期组织相关主题的讨论。 通过每月一次的科学研讨会和年度科学务虚会/外部咨询委员会来吸引青少年吸电子烟 会议，支持科学演示文稿、手稿和向联邦提交的材料的制定 并实施三个研究项目之间以及外部的数据共享政策 最后，行政核心将聘请专家在外部顾问委员会中任职，以实现项目目标。 审查 MARVEL 的近期和长期目标，监控这些目标的进展情况，并 提供有关研究设计、结果解释和转化工作的意见。