Predoctoral Training at the Interface Chemistry and Biology

界面化学与生物学博士前培训

• 批准号: 10628150
• 负责人: Jason Michael Crawford
• 金额: $ 53.05万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628150
• 关键词: Biology; Chemistry; Training; pre-doctoral

Project Summary/Abstract The broad mission of the predoctoral Chemistry/Biology Interface Training Program (CBITP) is to educate, train, and develop early-career scientists of diverse backgrounds to be thought leaders, role models and innovators at the Chemistry/Biology Interface for the greater benefit of humanity. The overall objective of the program is to train scientists who will make strong contributions to the chemical biological sciences leading to a sustained impact, ultimately benefitting society. During their supported training period in years 2 (5 students) and 3 (5 students) of the overall CBITP, students will: 1) Develop broad background knowledge of modern chemical biology research; 2) Develop strong background knowledge of detailed methods used in the chemical biology field; 3) Demonstrate advanced knowledge in specialized areas of chemical biology, including critical evaluation of molecular structure, function, (bio)synthesis, reactivity, and application in basic cellular/ organismal physiology; 4) Design, perform and communicate original, high-quality, rigorous (robust controls and statistical analysis), and ethically-conducted research upon critically examining previous scientific knowledge in chemical biology; 5) Express self-efficacy and professionalism to navigate the biomedical science career landscape; and 6) Develop professional oral and written communication skills. As large pharma internal Research & Development (R&D) efforts have decreased, job opportunities within the growing biotech/biopharma sector have increased. The founding of new biopharma ventures, by definition, involves a combination of chemistry and biology. The rationale for the training of students at this interface will not only help supply the workforce in the biotech/biopharma sector but will also produce the next generation of faculty and entrepreneurs to promote science and technology innovations and maintain U.S. leadership in these areas on the world stage. The program takes advantage of the very deep and diverse chemical, biological, and biomedical sciences applicant pool at Yale University as well as the extraordinary research strengths of the associated faculty. We have established a rigorous CBITP core curriculum with new and intensive half credit modules, which allows the students more flexibility in matching instruction and coursework with their educational and research needs. We have also established an assortment of CBITP-specific hands-on research (e.g., high-throughput screening, genomics, proteomics, etc) and career (e.g., internships with biopharma, alternative careers in bioscience, etc) workshops in addition to chemical biology symposia and conferences to promote overall student and program successes. To evaluate the efficacy, training outcomes, and career outcomes emerging from our existing and new programmatic activities, in addition to exploring the experiences of our trainees, we will employ a data-driven mixed-methods approach for continuous refinement. Collectively, we propose to modernize our successful 20-year CBITP for this new, next generation CBITP.

项目摘要/摘要 专业化学/生物学界面培训计划（CBITP）的广泛使命是教育， 训练并发展具有不同背景的早期职业科学家，成为思想领导者，榜样和 化学/生物学界面的创新者为人类的更大益处。总体目标 计划是培训科学家，他们将为化学生物科学做出巨大贡献的科学家 持续影响，最终使社会受益。在2年级（5名学生）的支持培训期间 总体CBITP的3个（5名学生）将：1）发展现代的广泛背景知识 化学生物学研究； 2）在化学中使用详细方法的详细背景知识 生物学领域； 3）在化学生物学专业领域展示高级知识，包括关键 评估分子结构，功能，（BIO）合成，反应性以及在基本细胞/ 有机生理； 4）设计，执行和交流原始，高质量，严格的（可靠的控件 和统计分析），并在批判性研究以前的科学方面进行了道德规范的研究 化学生物学知识； 5）表达自我效能和专业精神来导航生物医学 科学职业景观； 6）发展专业的口头和书面沟通技巧。作为大型制药 内部研究与发展（R＆D）的努力有所减少，在不断增长的工作机会 生物技术/生物制药部门有所增加。根据定义，新生物制药的建立涉及 化学和生物学的结合。在此界面上培训学生的理由不仅将 帮助在生物技术/生物制药领域提供劳动力，但也将产生下一代教师 和企业家促进科学和技术创新并在这些领域保持美国领导 在世界舞台上。该计划利用了非常深而多样的化学，生物学和 耶鲁大学的生物医学科学申请人池以及特殊的研究优势 相关教师。我们已经建立了一个严格的CBITP核心课程，并具有新的一半学分 模块，这使学生可以更灵活地将指导和课程与他们的课程匹配 教育和研究需求。我们还建立了各种CBITP特定的实践 研究（例如，高通量筛查，基因组学，蛋白质组学等）和职业（例如，实习 除化学生物学专题讨论会和 会议促进整体学生和计划成功。评估疗效，培训结果， 除了探索我们现有和新的程序化活动之外 我们的学员的经验，我们将采用数据驱动的混合方法方法进行连续精炼。 总的来说，我们建议为这个新的下一代CBITP现代化我们成功的20年CBITP。