The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank

环境空气污染对玻璃化冷冻供卵母细胞库生育力的影响

• 批准号: 10624827
• 负责人: Audrey Jane Gaskins
• 金额: $ 24.65万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624827
• 关键词: Address; Adverse effects; Affect; Air Pollution; Antral; Assisted Reproductive Technology; Autologous; Biological; Birth Rate; Birth Weight; Carbon; Carbon Monoxide; China; Clinic; Clinical; Couples; Development; Elements; Embryo; Embryo Transfer; Embryonic Development; Endometrial; Endometrium; Environment; Environmental Exposure; Europe; Event; Exposure to; Female; Fertility; Fertility Rates; Fertilization; Germ Cells; Gestational Age; Health; Human; Infertility; Knowledge; Link; Live Birth; Mediating; Medical Assistance; Modeling; Motor Vehicles; Nitrogen Dioxide; Nitrogen Oxides; Oocyte Donation; Oocytes; Oogenesis; Outcome; Ovarian Stimulations; Ozone; Paternal Exposure; Patients; Physicians; Population; Predisposition; Pregnancy; Pregnancy Outcome; Pregnancy loss; Premature Birth; Privatization; Probability; Reproduction; Research; Resources; Risk; Sampling; Sex Ratio; Spermatogenesis; Sulfur Dioxide; Time; United States; Uterus; Woman; ambient air pollution; blastocyst; coarse particles; cohort; cost effective; embryo cryopreservation; embryo quality; epidemiology study; global health; human model; implantation; male; men; novel; oocyte quality; ovarian reserve; pollutant; reproductive; reproductive outcome; spatiotemporal; sperm cell; traffic-related air pollution

PROJECT SUMMARY/ABSTRACT Air pollution, particularly due to motor vehicles, is a ubiquitous exposure and a significant global health threat, responsible for many adverse health outcomes. Emerging evidence also suggests that traffic-related air pollution may be related to lower fecundity and fertility among couples attempting to conceive both with and without medical assistance. However, the specific pollutants, exposure windows, and biological mechanisms underlying these associations remain understudied. To address these important knowledge gaps, this proposal will use a novel and emerging model of human fertility- vitrified donor oocyte assisted reproductive technology (ART)- to evaluate how air pollution influences human reproduction using a large cohort of oocyte donors and oocyte recipient couples attending a private fertility clinic in Atlanta, GA (2008- 2019). Residential exposure to traffic-related air pollution will be derived during multiple biologically relevant windows of exposure in the female donor, female recipient, and male recipient partner using fine-scale spatiotemporal models of nitrogen oxides, carbon monoxide, fine particular matter (PM), and elemental carbon as well as sulfur dioxide, ozone, nitrogen dioxide, PM10 , and PM constituents. Vitrified donor oocyte ART represents an ideal population to investigate the mechanisms underlying any associations between air pollution and fertility as exposures to the oocyte and uterine environment are uncorrelated in time or space and exposures to the oocyte and sperm are uncorrelated during the relevant exposure windows for fertilization and embryo development. Furthermore, by studying patients undergoing ART, it is possible to determine exact periods of air pollution exposure and directly observe early reproductive outcomes, such as fertilization and early embryo development that would never be observed in couples conceiving without assistance. This research will determine the independent effects of air pollution exposure during oogenesis and spermatogenesis on fertilization and early embryo development, the independent effects of air pollution on pregnancy outcomes as mediated through the oocyte and the endometrium, and the extent to which air pollution affects fertility potential in young, healthy women. Findings from this proposal will have major

项目概要/摘要 空气污染，尤其是机动车造成的空气污染，是一种普遍存在的污染，对全球健康产生重大影响 威胁，造成许多不良健康结果。新出现的证据还表明，与交通相关的 空气污染可能与试图同时怀孕的夫妇的生育力和生育能力降低有关 并且没有医疗救助。然而，具体的污染物、暴露窗口和生物 这些关联背后的机制仍未得到充分研究。解决这些重要知识 差距，该提案将使用一种新颖的、新兴的人类生育模型——玻璃化供体卵母细胞辅助 生殖技术（ART）——利用大量数据来评估空气污染如何影响人类生殖 前往佐治亚州亚特兰大一家私人生育诊所就诊的卵母细胞捐赠者和卵母细胞接受者夫妇队列（2008- 2019）。住宅暴露于与交通相关的空气污染将源自多个生物相关过程 使用细尺度测量女性捐赠者、女性接受者和男性接受者伴侣的暴露窗口 氮氧化物、一氧化碳、细颗粒物 (PM) 和元素的时空模型 碳以及二氧化硫、臭氧、二氧化氮、PM10 和 PM 成分。玻璃化供体卵母细胞 ART 代表了研究空气之间任何关联的潜在机制的理想人群 污染和生育能力，因为卵母细胞和子宫环境的暴露在时间或空间上不相关 在相关暴露窗口内，卵母细胞和精子的暴露是不相关的 受精和胚胎发育。此外，通过研究接受 ART 的患者，有可能 确定空气污染暴露的确切时期并直接观察早期生殖结果，例如 受精和早期胚胎发育在没有怀孕的夫妇中永远不会观察到 协助。这项研究将确定卵子发生过程中空气污染暴露的独立影响 和精子发生对受精和早期胚胎发育的影响，空气污染的独立影响 通过卵母细胞和子宫内膜介导的妊娠结局，以及空气的程度 污染影响年轻健康女性的生育潜力。该提案的调查结果将产生重大影响