Maternal Exposure to Air Pollution and Early Pregnancy Outcomes

母亲接触空气污染和早期妊娠结果

• 批准号: 10094056
• 负责人: Audrey Jane Gaskins
• 金额: $ 23.77万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10094056
• 关键词: Academic Medical Centers; Address; Adherence; Affect; Air Pollutants; Air Pollution; Antioxidants; Area; Award; Biological Markers; Blood specimen; Boston; Calendar; Clinic; Couples; Data; Development; Diet; Dietary Factors; Dietary Questionnaires; Dietary intake; Environmental Epidemiology; Environmental Hazards; Epidemiologist; Exposure to; Fertility; Fertilization; Fertilization in Vitro; Folic Acid; Food; Frequencies; Future; General Population; Geographic Information Systems; Health; Intake; Learning; Link; Massachusetts; Maternal Exposure; Measures; Mentors; Modeling; Monitor; Omega-3 Fatty Acids; Outcome; Phase; Population; Positioning Attribute; Predisposition; Pregnancy; Pregnancy Outcome; Pregnancy loss; Premature Birth; Prospective cohort study; Public Health; Questionnaires; Research; Time; Training; Woman; adverse pregnancy outcome; base; career; cohort; early pregnancy; early pregnancy loss; epidemiology study; experience; failure Implantation; fetal; fine particles; human data; metabolome; metabolomics; negative affect; novel; novel marker; nutrition; nutritional epidemiology; oocyte quality; personal exposure monitor; prevent; prospective; recruit; reproductive; reproductive epidemiology; reproductive outcome; skills; software systems; study population; training opportunity; urban area; zygote

PROJECT SUMMARY/ABSTRACT Exposure to air pollution in the general population is universal. Similarly, pregnancy loss is an all too common outcome affecting up to 75% of fertilized ova and 30% of recognized pregnancies. Emerging human data suggest that air pollution negatively affects early pregnancy outcomes, particularly early pregnancy loss; however the evidence is limited and the specific mechanisms and time window of susceptibility still remain to be determined. To date there are also few strategies to counteract or minimize the adverse health consequences of air pollution. Identifying potential dietary factors that could ameliorate the negative reproductive effects of air pollution would be of great public health significance as these exposures tend to be easier to directly modify than personal exposure to air pollution. Using validated spatial-temporal regression models of air pollution exposure, validated dietary questionnaires, personal air pollution monitors, and novel metabolomics biomarkers, this K99/R00 award application will determine the extent to which air pollution and its specific constituents affect fecundity, the potential for diet to modify these associations, and the possible mechanisms of action using a cohort of women undergoing in vitro fertilization in Boston, Massachusetts. Dr. Audrey Gaskins will be mentored by Dr. Francine Laden, an expert in environmental epidemiology, and Dr. Jorge Chavarro, a leader in nutrition and reproductive epidemiology. The applicant will also collaborate closely with Drs. Joel Schwartz, Brent Coull, Russ Hauser, and Chirag Patel to further her expertise in environmental epidemiology. During the K99 phase of the award, Dr. Gaskins will build on her expertise in nutritional and reproductive epidemiology and will be trained in air pollution exposure assessment using validated models to predict ambient exposure and air pollution monitors to measure continuous personal exposure. Dr. Gaskins will also receive training in the analysis of “-omic” data in anticipation of the R00 phase where prospectively collected blood samples will be used to identify novel early effect markers of air pollution using metabolomics. Findings from the research proposed in this application may inform public health strategies to prevent early pregnancy loss, the most common adverse pregnancy outcome, while increasing our understanding of the mechanisms by which air pollution affects early pregnancy endpoints. All of this will be possible through the use of a novel study population, women undergoing in vitro fertilization where many early developmental measures can be observed and novel biomarkers can be assessed through metabolomics. The outstanding training opportunities in research areas such as air pollution and metabolomics with key leaders in the field will greatly enhance the skills and capabilities of the candidate and position her for a successful and independent career as an environmental and reproductive epidemiologist.

项目摘要/摘要 普通人群暴露于空气污染是普遍的。同样，怀孕是一个太普遍的 结果影响多达75％的受精卵和30％的公认怀孕。新兴的人类数据 表明空气污染对早期妊娠结局产生负面影响，尤其是早期妊娠丧失； 但是，证据是有限的，易感性的具体机制和时间窗口仍在 可以确定。迄今为止，很少有策略来抵消或最大程度地减少不良健康 空气污染的后果。确定可能改善负面的潜在饮食因素 空气污染的生殖影响将具有很大的公共卫生意义，因为这些暴露往往是 比个人接触空气污染更容易直接修改。使用经过验证的时空回归 空气污染的模型，经过验证的饮食问卷，个人空气污染监视器和新颖 代谢组学生物标志物，该K99/R00奖励申请将确定空气污染和 它的特定构成影响繁殖力，饮食改变这些关联的潜力以及可能的 马萨诸塞州波士顿接受体外受精的妇女队列的作用机制。博士 环境流行病学专家Francine Laden博士将考虑Audrey Gaskins和Dr. 豪尔赫·查瓦罗（Jorge Chavarro），营养和生殖流行病学的领导者。申请人还将密切合作 与博士。乔尔·施瓦茨（Joel Schwartz），布伦特·库尔（Brent Coull），拉斯·霍瑟（Russ Hauser）和奇拉格·帕特尔（Chirag Patel 流行病学。在该奖项的K99阶段，Gaskins博士将建立在营养方面的专业知识和 生殖流行病学，并将使用经过验证的模型进行空气污染的评估培训 预测环境暴露和空气污染监测器，以衡量连续的个人暴露。加斯金斯博士将 还可以在预期R00阶段的“ - 摩尼克”数据分析中接受培训 收集的血液样本将用于鉴定使用代谢组学的新型空气污染的早期效应标志物。 本申请中提出的研究的发现可能会为公共卫生策略提供信息，以防止早期 怀孕丧失，是最常见的不良怀孕结局，同时增加了我们对 空气污染影响早期妊娠终点的机制。所有这些都是通过 使用新的研究人群，妇女在许多早期发育中接受体外受精 可以观察到措施，可以通过代谢组学评估新颖的生物标志物。杰出 与该领域主要领导者等研究领域的培训机会，例如空气污染和代谢组学 极大地提高了候选人的技能和能力，并将她定位为成功和独立 作为环境和生殖流行病学家的职业。