Training Program in Substance Use Disorders

药物滥用障碍培训计划

• 批准号: 10623170
• 负责人: Paul J. Kenny
• 金额: $ 55.32万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623170
• 关键词: Substance Use Disorder; Training Programs

SUMMARY The Training Program in Substance Use Disorders at the Icahn School of Medicine at Mount Sinai (ISMMS) will offer late-stage predoctoral (PhD) students and early-stage postdoctoral fellows an integrated program of training in substance use disorders (SUDs) research that leverages the exceptional expertise in cellular, molecular and behavioral neuroscience, translational neuroscience, neurology, psychiatry, genomic science and pharmacological sciences at ISMMS. The overarching goal of the program is to provide rigorous, broad- based, individualized, and multidisciplinary training with enhanced opportunities for mentoring, collaboration, and career development designed to prepare the next generation of independent investigators in SUDs research. At the heart of this new Training Program will be a superb training faculty representing remarkable diversity in basic and clinically relevant topics; from synaptic plasticity and chromatin remodeling; cognitive, social, and emotional disorders; disorders of mood, motivation, and anxiety; addiction; human neuropsychology; and cognitive neuroscience – all relevant to SUDs. The Training Program comprises inter- related components: academic coursework, laboratory training, non-curricular training activities (seminars, retreats, etc.), testing/evaluation, teaching opportunities, mentoring, and career development activities. The diverse research environment at ISMMS will provide for laboratory opportunities in core areas of strength, including in translational neuroscience, computational neuroscience, neuropsychiatric genomics, neuroimaging, epigenetics, and synaptic and behavioral plasticity, and the study of diverse model systems. The Training Program includes more than a dozen initiatives that have been newly created or adapted from existing programs to support training in SUDs, which emphasize multidisciplinary collaborations, and the promotion of exceptional rigor and creativity. Pre- and post-doctoral trainees will participate in required and optional training activities to ensure strong grounding in basic neuroscience and opportunities to learn from and with peers and faculty from across ISMMS, including those in the Graduate School of Biomedical Sciences, the medical school, interdisciplinary Centers and Institutes, and the Friedman Brain Institute. Creating a structured culture of mentoring across the career continuum of participants is a hallmark feature of the Training Program. Formal and informal advising and mentoring will be integrated into training across roles and levels, including mentoring opportunities for training faculty and sponsors (preceptors). Integrating predoctoral and postdoctoral training through formal mechanisms will provide greater continuity in the overall training experience, enhanced opportunities for collaboration among trainees interested in pursuing careers in SUDs research, and will benefit the neuroscience research effort at ISMMS. The Training Program in Substance Use Disorders will prepare the most promising trainees for productive, independent careers in SUD research at all levels – from preclinical genetics, cellular and molecular mechanisms of the disorders, to clinical research and interventions.

概括 西奈山伊坎医学院药物使用障碍培训项目 (ISMMS) 将为后期博士前（PhD）学生和早期博士后研究员提供综合课程 物质使用障碍 (SUD) 研究培训，利用细胞、 分子和行为神经科学、转化神经科学、神经病学、精神病学、基因组科学 ISMMS 的总体目标是提供严格、广泛的 基于个性化和多学​​科的培训，增加指导、协作、 旨在为 SUD 的下一代独立调查员做好准备的职业发展 这项新培训计划的核心将是一支代表卓越的优秀培训师资队伍。 基础和临床相关主题的多样性；来自突触可塑性和染色质重塑； 社交和情绪障碍；情绪、动机和焦虑障碍； 神经心理学；和认知神经科学——所有这些都与 SUD 相关。 相关组成部分：学术课程、实验室培训、非课程培训活动（研讨会、 静修等）、测试/评估、教学机会、指导和职业发展活动。 ISMMS 的多元化研究环境将为核心优势领域的实验室提供机会， 包括转化神经科学、计算神经科学、神经精神基因组学、 神经影像学、表观遗传学、突触和行为可塑性以及不同模型系统的研究。 培训计划包括十多项新创建或改编自的举措 支持 SUD 培训的现有计划，强调多学科合作，以及 促进博士前和博士后学员的卓越智力和创造力。 可选的培训活动，以确保基础神经科学的坚实基础以及学习和学习的机会 与来自 ISMMS 的同行和教师，包括生物医学科学研究生院的同行和教师， 医学院、跨学科中心和研究所以及弗里德曼脑研究所创建了一个结构化的机构。 在参与者的整个职业生涯中提供指导的文化是培训计划的一个标志性特征。 正式和非正式的建议和指导将纳入跨角色和级别的培训，包括 培训教师和资助者（导师）的指导机会。 通过正式机制进行的培训将提高整体培训经验的连续性，增强 有兴趣从事 SUD 研究的学员之间的合作机会，并将受益 ISMMS 的神经科学研究工作将准备药物使用障碍培训计划。 最有前途的实习生，可在各个级别的 SUD 研究中实现富有成效、独立的职业生涯——从临床前开始 疾病的遗传学、细胞和分子机制，以及临床研究和干预措施。

项目成果

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR.

四环抗抑郁药对血清素受体 5-HT1eR 和 5-HT1FR 的意外激动作用的结构见解。

• DOI: 10.1101/2023.10.05.561100
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Zilberg,Gregory;Parpounas,AlexandraK;Warren,AudreyL;Fiorillo,Bianca;Provasi,Davide;Filizola,Marta;Wacker,Daniel
• 通讯作者: Wacker,Daniel