Training Program in Substance Use Disorders

药物滥用障碍培训计划

• 批准号: 10623170
• 负责人: Paul J. Kenny
• 金额: $ 55.32万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623170
• 关键词: Substance Use Disorder; Training Programs

SUMMARY The Training Program in Substance Use Disorders at the Icahn School of Medicine at Mount Sinai (ISMMS) will offer late-stage predoctoral (PhD) students and early-stage postdoctoral fellows an integrated program of training in substance use disorders (SUDs) research that leverages the exceptional expertise in cellular, molecular and behavioral neuroscience, translational neuroscience, neurology, psychiatry, genomic science and pharmacological sciences at ISMMS. The overarching goal of the program is to provide rigorous, broad- based, individualized, and multidisciplinary training with enhanced opportunities for mentoring, collaboration, and career development designed to prepare the next generation of independent investigators in SUDs research. At the heart of this new Training Program will be a superb training faculty representing remarkable diversity in basic and clinically relevant topics; from synaptic plasticity and chromatin remodeling; cognitive, social, and emotional disorders; disorders of mood, motivation, and anxiety; addiction; human neuropsychology; and cognitive neuroscience – all relevant to SUDs. The Training Program comprises inter- related components: academic coursework, laboratory training, non-curricular training activities (seminars, retreats, etc.), testing/evaluation, teaching opportunities, mentoring, and career development activities. The diverse research environment at ISMMS will provide for laboratory opportunities in core areas of strength, including in translational neuroscience, computational neuroscience, neuropsychiatric genomics, neuroimaging, epigenetics, and synaptic and behavioral plasticity, and the study of diverse model systems. The Training Program includes more than a dozen initiatives that have been newly created or adapted from existing programs to support training in SUDs, which emphasize multidisciplinary collaborations, and the promotion of exceptional rigor and creativity. Pre- and post-doctoral trainees will participate in required and optional training activities to ensure strong grounding in basic neuroscience and opportunities to learn from and with peers and faculty from across ISMMS, including those in the Graduate School of Biomedical Sciences, the medical school, interdisciplinary Centers and Institutes, and the Friedman Brain Institute. Creating a structured culture of mentoring across the career continuum of participants is a hallmark feature of the Training Program. Formal and informal advising and mentoring will be integrated into training across roles and levels, including mentoring opportunities for training faculty and sponsors (preceptors). Integrating predoctoral and postdoctoral training through formal mechanisms will provide greater continuity in the overall training experience, enhanced opportunities for collaboration among trainees interested in pursuing careers in SUDs research, and will benefit the neuroscience research effort at ISMMS. The Training Program in Substance Use Disorders will prepare the most promising trainees for productive, independent careers in SUD research at all levels – from preclinical genetics, cellular and molecular mechanisms of the disorders, to clinical research and interventions.

概括 西奈山（ISMMS）的伊坎医学院的药物使用障碍培训计划 将为后期前（PHD）学生和早期博士后研究员提供一个综合计划 对药物使用障碍（SUD）研究的培训，该研究利用了卓越的细胞专家， 分子和行为神经科学，转化神经科学，神经学，精神病学，基因组科学 和ISMM的药物科学。该计划的总体目标是提供严格，广泛的 基于，个性化和多学​​科培训，并增加了心理，协作的机会 和职业发展旨在为下一代独立调查员做好准备 研究。这项新培训计划的核心将是一项出色的培训教师，代表非凡 基本和临床相关主题的多样性；来自合成可塑性和染色质重塑；认知的， 社会和情感障碍；情绪，动机和动画的疾病；瘾;人类 神经心理学；和认知神经科学 - 都与SUD有关。培训计划包括 相关组成部分：学术课程，实验室培训，非课程培训活动（研讨会， 务虚会等），测试/评估，教学机会，心理和职业发展活动。 ISMM的多样化研究环境将为核心力量领域提供实验室机会， 包括转化神经科学，计算神经科学，神经精神病学基因组学， 神经影像学，表观遗传学以及突触和行为可塑性，以及多种模型系统的研究。 该培训计划包括新创建或改编的十几个计划 现有的计划支持SUD培训，该计划强调多学科合作，以及 促进出色的严格和创造力。博士后学员将参与要求， 可选的培训活动，以确保基本神经科学的强大基础和向学习和学习的机会 与来自ISMM的同龄人和教师，包括生物医学研究生院的人， 医学院，跨学科中心和机构以及弗里德曼脑研究所。创建一个结构化 参与者的职业生涯连续性的指导文化是培训计划的标志性特征。 正式和非正式的咨询和心理将纳入跨角色和层次的培训，包括 指导培训教师和赞助商（主持人）的机会。整合术前和博士后 通过正式机制培训将在整体培训经验中提供更大的连续性，增强 有兴趣从事SUDS研究职业的学员之间合作的机会，并将受益 ISMM的神经科学研究工作。药物使用障碍的培训计划将准备 从临床前，最有前途的学员从事SUD研究的生产性独立职业 - 临床前学会 疾病的遗传学，细胞和分子机制，用于临床研究和干预措施。

项目成果

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR.

四环抗抑郁药对血清素受体 5-HT1eR 和 5-HT1FR 的意外激动作用的结构见解。

• DOI: 10.1101/2023.10.05.561100
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Zilberg,Gregory;Parpounas,AlexandraK;Warren,AudreyL;Fiorillo,Bianca;Provasi,Davide;Filizola,Marta;Wacker,Daniel
• 通讯作者: Wacker,Daniel