Epilepsy Research Training Program

癫痫研究培训计划

基本信息

批准号：
10621287
负责人：
Tallie Z. Baram
金额：
$ 29.44万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10621287
关键词：
Epilepsy Research Training Training Programs

项目摘要

Abstract This proposal aims to renew support for a Training Program in Epilepsy Research. The overall goals of the Program are to: (1) Provide Trainees with a broad basic, translational and clinical understanding of Epilepsy and the approaches for its study. (2) Provide Trainees with the tools to perform top-quality science via workshops and discussions that address quantitative aspects of research, including study design, statistics, and reproducibility. These are taught in small groups using problem- solving approaches and Trainee peer- discussions. (3) Provide Trainees with state of the art scientific training via assignment to diverse modern laboratories and rigorous implementation of oversight by individualized committees. (4) Provide Trainees with the knowledge of the diverse facets of Science-related career choices and prepare them for these paths via career development activities. (5) Facilitate well-being and integration of Trainees from diverse backgrounds by creating a Training Community where trainees at pre-and postdoctoral level intersect, exchange role models and advice, and support one another- thus enhancing individual and group success. The Training Program in Epilepsy Research will accomplish these goals via individualized, committee- supervised research training in the labs of 14 well-funded and enthusiastic Mentors. Importantly, the training experience is enriched by program-specific courses, workshops, career-development sessions, Trainee-run gatherings, mandated presentations, as well as seminars and symposia that draw in the UCI Neuroscience community and potential trainees. The Training Program in Epilepsy Research thus provides added value to supported trainees as well as to numerous Trainees who join and benefit from our activities. Our success to date in achieving our ambitious training goals derives from an outstanding pool of candidates, and from synergy with the UCI Epilepsy Research Center and the UCI Clinical Epilepsy Program, which interact to provide a multifaceted Training Experience. These assets are complemented by an open and interactive research atmosphere, significant resources, and abundant collaborations among Program faculty. Our approach to Epilepsy as “a Window to Brain Plasticity” promotes both basic and translational approaches to research on Epilepsy and its cognitive and emotional co-morbidities. Given the trajectories of academic careers, tangible measures of success of our training approach are becoming evident as the Training Program in Epilepsy Research is in its 14th year. Our goal for the coming years of the Program, one of only two Epilepsy-focused T32s in the U.S, are to capitalize on our success and learn from trainee and faculty input to further enhance the training experience: (1) From our 5 pre-doctoral Trainees, we have learnt the beneficial effects of pre-postdoc trainee interactions to both, and request that maintain this structure; (2) We aim to increase MD recruitment (currently 12%), and that of individuals from diverse backgrounds (currently 17%, a sixth of our Trainees);). (3) We aim to intensify teaching of the quantitative aspects of research as well as of rigorous research via hands-on sessions integrated with the CTSA. Thus, the Training Program in Epilepsy will build on its record of launching talented Neuroscientists, including minority and women into sustainable academic careers, thus enhancing the future workforce in Neuroscience Research.

抽象的该提案旨在重新支持癫痫研究培训计划的总体目标。计划旨在： (1) 为学员提供对癫痫的广泛基础、转化和临床理解 (2) 为学员提供进行高质量科学研究的工具。讨论研究的定量方面，包括研究设计、统计、这些都是以小组形式使用解决问题的方法和学员同伴进行教授的。 (3) 通过分配到不同的现代环境，为学员提供最先进的科学培训。 (4) 为学员提供了解与科学相关的职业选择的各个方面，并为他们为这些道路做好准备 (5) 促进来自不同背景的学员的福祉和融入。创建一个培训社区，让博士前和博士后级别的学员相互交叉、交流榜样和建议，并相互支持——从而提高个人和团体的成功。癫痫研究培训计划将通过个性化的委员会来实现这些目标在 14 名资金充足且热情的导师的实验室中监督研究培训。通过特定项目的课程、讲习班、职业发展会议、实习生举办的课程来丰富经验 UCI 神经科学领域的聚会、强制演讲以及研讨会和座谈会因此，癫痫研究培训计划为社区和潜在的学员提供了附加值。支持学员以及众多加入我们的活动并从中受益的学员。迄今为止，我们在实现雄心勃勃的培训目标方面取得的成功得益于优秀的候选人库，以及与 UCI 癫痫研究中心和 UCI 临床癫痫项目的协同作用，互动以提供多方面的培训体验这些资产得到了开放和开放的补充。项目教师之间互动的研究氛围、重要的资源和丰富的合作。我们将癫痫作为“大脑可塑性之窗”的方法促进了基础方法和转化方法研究癫痫及其认知和情感并发症。鉴于学术生涯的轨迹，我们培训方法成功的具体衡量标准是随着癫痫研究培训项目进入第 14 个年头，这一点变得越来越明显。该计划是美国仅有的两个专注于癫痫的 T32 计划之一，我们未来几年的目标是利用我们的成功并从学员和教师的意见中学习，进一步增强培训体验： (1) 从我们的5位博士前实习生身上，我们了解到了博士后实习生互动的有益效果并要求维持这一结构；(2) 我们的目标是增加 MD 招聘（目前为 12%），以及来自不同背景的个人（目前为 17%，占学员的六分之一）；) (3) 我们的目标是加强培训。通过实践课程教授研究的定量方面以及严谨的研究因此，癫痫培训项目将建立在其培养人才的基础上。神经科学家，包括少数族裔和女性，参与可持续的学术职业，从而改善未来神经科学研究的劳动力。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Auditory brainstem responses are impaired in EphA4 and ephrin-B2 deficient mice.

EphA4 和 ephrin-B2 缺陷小鼠的听觉脑干反应受损。

DOI：
10.1016/j.heares.2007.09.003
发表时间：
2008
期刊：
Hearing research
影响因子：
2.8
作者：
Miko,IlonaJ;Henkemeyer,Mark;Cramer,KarinaS
通讯作者：
Cramer,KarinaS

Caudate atrophy and impaired frontostriatal connections are linked to executive dysfunction in temporal lobe epilepsy.

DOI：
10.1016/j.yebeh.2011.03.013
发表时间：
2011-05
期刊：
Epilepsy & behavior : E&B
影响因子：
0
作者：
Riley JD;Moore S;Cramer SC;Lin JJ
通讯作者：
Lin JJ

Optogenetic intervention of seizures improves spatial memory in a mouse model of chronic temporal lobe epilepsy.

DOI：
10.1111/epi.16445
发表时间：
2020-03
期刊：
Epilepsia
影响因子：
5.6
作者：
Kim HK;Gschwind T;Nguyen TM;Bui AD;Felong S;Ampig K;Suh D;Ciernia AV;Wood MA;Soltesz I
通讯作者：
Soltesz I

Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus.

DOI：
10.1016/j.ebiom.2016.03.039
发表时间：
2016-05
期刊：
EBioMedicine
影响因子：
11.1
作者：
Barry JM;Sakkaki S;Barriere SJ;Patterson KP;Lenck-Santini PP;Scott RC;Baram TZ;Holmes GL
通讯作者：
Holmes GL

HDAC3 is a negative regulator of cocaine-context-associated memory formation.

DOI：
10.1523/jneurosci.4472-12.2013
发表时间：
2013-04-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Rogge GA;Singh H;Dang R;Wood MA
通讯作者：
Wood MA