Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities

破碎的早期生活经历、异常的电路成熟、情感脆弱

• 批准号: 10745808
• 负责人: Tallie Z. Baram
• 金额: $ 26.09万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-17 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745808
• 关键词: 12 year old; 8 year old; Address; Age; Anhedonia; Behavior assessment; Birth; Black race; Caring; Cause of Death; Cessation of life; Child; Cognitive; Communities; Comprehension; Consent; Dangerousness; Development; Emergency department visit; Emotional; Ethnic Population; Exclusion; Feeling suicidal; Fright; Grant; Iatrogenesis; Income; Infrastructure; Intervention; Investigation; Knowledge; Life; Life Experience; Measures; Mental Health Services; Methods; Mothers; National Institute of Mental Health; Outcome; Outcome Measure; Parental Consent; Parents; Patient Self-Report; Population; Population Heterogeneity; Provider; Psychopathology; Public Health; Race; Randomized; Recording of previous events; Reporter; Reporting; Research; Research Methodology; Risk; Risk Assessment; Role; Sampling; Screening procedure; Self-Injurious Behavior; Severities; Suicide; Suicide attempt; Suicide prevention; Testing; Vulnerable Populations; Youth; age group; cohort; community engagement; disadvantaged background; early life adversity; efficacy testing; experience; falls; improved; innovation; instrument; marginalized population; novel; parent grant; preadolescence; response; social culture; study population; suicidal behavior; suicidal risk; suicide rate; tool; tool development

PROJECT SUMMARY Suicidal thoughts and behaviors (STBs) are the 5th leading cause of death among young children and non-fatal STBs account to close to half of emergency room visits in this age group. There is a dearth of research examining STBs among pre-adolescent children and a critical need for validated screening tools to identify children in need of intervention. Existing STB research tends to exclude individuals from marginalized backgrounds further limiting the generalizability of already sparse research in this population. Improving suicide prevention in children requires research innovation for this vulnerable group. There are three particularly critical barriers to identifying children at risk of STBs: 1) parental fears that STB assessment is iatrogenic; 2) lack of developmentally appropriate tools and methods for identifying child risk; and 3) lack of culturally appropriate and valid tools to address parent concerns and to identify child risk. This supplement in response to NOT-MH-22-195 directly addresses these barriers to identifying STBs in young children by leveraging an existing cohort of socioculturally and economically diverse mothers and their 5- to 8-year-old children, followed intensively from before birth with comprehensive assessments of cognitive and emotional development supported by a NIMH Conte Center grant (P50 MH096889). Incorporating critical community perspectives, this supplement tests the following aims: 1. Provide developmentally and culturally appropriate methods for assessing and quantifying STBs in 5- to 8-year- old children; 2. Test the efficacy of a brief informational intervention to increase parent consent to probe STBs in 5- to 8-year-old children; 3. Validate/implement novel instruments for STB assessment capitalizing on a thoroughly characterized and culturally diverse cohort. The discoveries generated by this project address critical gaps in the development of tools to accurately assess STBs in young children in need of life saving intervention. Further, the proposed supplement falls within, and enriches, the scope of the parent grant. The parent grant investigates early origins of anhedonia and as STBs often accompany or follow anhedonia, this supplement provides an important complementary outcome measure. Additionally, the parent grant probes the role of unpredictable early life experiences in psychopathology and Aim 3 of the supplement enables assessment of the role of unpredictability in STBs. The present study has the potential to transform the study of STBs in children, by enhancing parent consent to assessment of STBs and increasing confidence in the validity of STB assessment in children.

项目概要 自杀念头和行为 (STB) 是幼儿和非致命性死亡的第五大原因 在这个年龄段，机顶盒占急诊室就诊人数的近一半。缺乏研究检验 青春期前儿童中的 STB 以及迫切需要经过验证的筛查工具来识别有需要的儿童 的干预。现有的 STB 研究倾向于进一步将边缘化背景的个体排除在外 限制了该人群中本已稀疏的研究的普遍性。改善儿童自杀预防 需要针对这一弱势群体进行研究创新。识别过程中存在三个特别关键的障碍 有 STB 风险的儿童： 1) 家长担心 STB 评估是医源性的； 2）缺乏发展 识别儿童风险的适当工具和方法； 3）缺乏文化上适当且有效的工具 解决家长的担忧并识别儿童风险。本补充直接回应 NOT-MH-22-195 通过利用现有的社会文化群体，解决识别幼儿 STB 的这些障碍 以及经济状况不同的母亲及其 5 至 8 岁的孩子，从出生前开始就进行了集中跟踪 由 NIMH Conte 中心拨款支持的认知和情感发展综合评估 （P50 MH096889）。本补充材料结合了重要的社区观点，测试了以下目标：1. 提供适合发展和文化的方法来评估和量化 5 至 8 年的 STB 老孩子； 2. 测试简短信息干预的有效性，以增加家长对调查机顶盒的同意 5至8岁儿童； 3. 验证/实施 STB 评估的新工具 具有完全特征和文化多样性的群体。该项目产生的发现解决了关键问题 在准确评估需要挽救生命干预的幼儿的 STB 的工具开发方面存在差距。 此外，拟议的补充属于并丰富了母基金的范围。家长补助 调查快感缺乏的早期起源，并且由于 STB 经常伴随或跟随快感缺乏，因此该补充 提供了一个重要的补充结果衡量标准。此外，家长拨款探讨了 精神病理学中不可预测的早期生活经历和补充的目标 3 能够评估 不可预测性在机顶盒中的作用。本研究有可能改变儿童 STB 的研究， 通过增强家长对 STB 评估的同意并增强对 STB 有效性的信心 对儿童的评估。

项目成果

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy.

• DOI: 10.1101/cshperspect.a022384
• 发表时间: 2016-03-01
• 期刊: Cold Spring Harbor perspectives in medicine
• 影响因子: 5.4
• 作者: Brennan GP;Baram TZ;Poolos NP
• 通讯作者: Poolos NP

Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health.

• DOI: 10.1017/s0954579422000141
• 发表时间: 2023-05
• 期刊: DEVELOPMENT AND PSYCHOPATHOLOGY
• 影响因子: 3.3
• 作者: Liu, Sabrina R.;Sandman, Curt A.;Davis, Elysia Poggi;Glynn, Laura M.
• 通讯作者: Glynn, Laura M.

Sharing brain mapping statistical results with the neuroimaging data model.

• DOI: 10.1038/sdata.2016.102
• 发表时间: 2016-12-06
• 期刊: SCIENTIFIC DATA
• 影响因子: 9.8
• 作者: Maumet, Camille;Auer, Tibor;Bowring, Alexander;Chen, Gang;Das, Samir;Flandin, Guillaume;Ghosh, Satrajit;Glatard, Tristan;Gorgolewski, Krzysztof J.;Helmer, Karl G.;Jenkinson, Mark;Keator, David B.;Nichols, B. Nolan;Poline, Jean-Baptiste;Reynolds, Richard;Sochat, Vanessa;Turner, Jessica;Nichols, Thomas E.
• 通讯作者: Nichols, Thomas E.

Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice.

• DOI: 10.1038/s41467-023-36780-x
• 发表时间: 2023-02-25
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Birnie, Matthew T. T.;Short, Annabel K. K.;de Carvalho, Gregory B. B.;Taniguchi, Lara;Gunn, Benjamin G. G.;Pham, Aidan L. L.;Itoga, Christy A. A.;Xu, Xiangmin;Chen, Lulu Y. Y.;Mahler, Stephen V. V.;Chen, Yuncai;Baram, Tallie Z. Z.
• 通讯作者: Baram, Tallie Z. Z.

Prospective examination of pre-trauma anhedonia as a risk factor for post-traumatic stress symptoms.

• DOI: 10.1080/20008198.2021.2015949
• 发表时间: 2022
• 期刊: European journal of psychotraumatology
• 影响因子: 5
• 作者: Acheson DT;Vinograd M;Nievergelt CM;Yurgil KA;Moore TM;Risbrough VB;Baker DG
• 通讯作者: Baker DG