Miniature Deep Thermal Imager for Continuous Monitoring of BAT Metabolism

用于连续监测 BAT 代谢的微型深层热成像仪

• 批准号: 8324550
• 负责人: Paolo Francesco Maccarini
• 金额: $ 19.12万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324550
• 关键词: Address; Adhesives; Affect; Back; Bandage; Brown Fat; Caliber; Clinical Research; Communication; Consumption; Coupling; Development; Devices; Diabetes Mellitus; Electromagnetics; Electronics; Energy Metabolism; Goals; Grant; Heating; Hour; Human; Human Activities; Human body; Image; Intervention; Investigation; Lead; Link; Measurement; Measures; Mediating; Medical; Metabolic; Metabolism; Methods; Modeling; Modification; Monitor; Obesity; Organ; Outcome; Outcomes Research; Pain; Painless; Patients; Pattern; Performance; Pharmaceutical Preparations; Play; Positron-Emission Tomography; Power Sources; Preparation; Process; Production; Radiation; Radiometry; Research; Role; Side; Skin; Stimulus; Surface; System; Techniques; Technology; Telemetry; Temperature; Testing; Thermogenesis; Thermometry; Time; Tissues; Toxic effect; Translating; Weight Gain; Wireless Technology; cost; design; detector; energy balance; insulin sensitivity; microwave electromagnetic radiation; miniaturize; new technology; novel strategies; sensor; tissue phantom; tool

DESCRIPTION (provided by applicant): The long term goal of this research is to create a miniature bandage-size non-invasive deep tissue thermal sensor that is sensitive to changes in tissue temperature at depth in the body. The objective of this project is to develop a low cost and harmless new tool for long term monitoring of metabolic activity of human brown adipose tissue (BAT). The rationale for undertaking this development is that there is currently no effective and reliable method for continuous monitoring of energy expenditure of a distributed organ like Brown Adipose Tissue (BAT) which is present in small multifocal depots. We intend to accomplish our objective by pursuing the following three specific aims: Aim 1: Design and fabricate a miniature radiometric sensor suitable for non-invasive measurement of thermal irregularities within 4 cm of the tissue surface. This sensor will require development of: 1.1) appropriate anatomical, thermal and electromagnetic models of BAT, 1.2) low profile microwave antenna with effective coupling to typical BAT regions, and 1.3) low power consumption integrated chip electronics (e.g. HEMT preamplifier, power detector, ultralow loss MEM switch, precision A/D converter). Aim 2: Integrate all components optimized in Aim 1 into an adhesive bandage-size patch sensor including radiometer circuitry, EMI shielding, battery power source, and wireless telemetry link. This miniaturized multichip circuit mounted on the back side ground plane of the receive antenna will require optimization of power consumption, thermal stability, and wireless communication for remote recording of temperature change over long time periods (hours to days) Aim 3: Characterize performance of microwave radiometric sensor in terms of sensing volume, accuracy and stability of temperature measurements, EMI rejection, and error free telemetry. Quantify antenna radiation patterns of the monitoring and telemetry antennas, and quantify temperature sensitivity of the multiband radiometer as functions of target size and depth in tissue and difference above core temperature in multilayer BAT phantoms - in preparation for subsequent use in humans. The expected outcome is a lightweight, adhesive bandage encased, safe and painless thermal monitoring sensor useful for clinical studies requiring long term characterization of energy production or utilization in tissue. The resulting technology should translate readily to thermal monitoring applications beyond this grant.

描述（由申请人提供）：这项研究的长期目标是创建一种微型绷带大小的非侵入性深层组织热传感器，该传感器对身体深处组织温度的变化敏感。该项目的目标是开发一种低成本且无害的新工具，用于长期监测人类棕色脂肪组织（BAT）的代谢活动。进行这项开发的理由是，目前没有有效且可靠的方法来连续监测分布式器官的能量消耗，例如存在于小型多焦点库中的棕色脂肪组织（BAT）。我们打算通过追求以下三个具体目标来实现我们的目标： 目标 1：设计和制造微型辐射传感器，适用于对组织表面 4 厘米内的热不规则性进行非侵入性测量。该传感器需要开发：1.1）适当的 BAT 解剖、热和电磁模型，1.2）与典型 BAT 区域有效耦合的薄型微波天线，以及 1.3）低功耗集成芯片电子器件（例如 HEMT 前置放大器、功率检测器、超低损耗 MEM 开关、精密 A/D 转换器）。目标 2：将目标 1 中优化的所有组件集成到胶带大小的贴片传感器中，包括辐射计电路、EMI 屏蔽、电池电源和无线遥测链路。这种安装在接收天线背面接地平面上的小型多芯片电路需要优化功耗、热稳定性和无线通信，以远程记录长时间（几小时到几天）的温度变化目标 3：表征微波的性能辐射传感器的传感体积、温度测量的准确性和稳定性、EMI 抑制和无差错遥测。量化监测和遥测天线的天线辐射方向图，并将多频段辐射计的温度灵敏度量化为目标尺寸和组织深度以及多层 BAT 体模中核心温度差异的函数，为后续在人类中的使用做好准备。预期的结果是一种轻质、粘性绷带包裹、安全、无痛的热监测传感器，可用于需要长期表征组织中能量产生或利用的临床研究。由此产生的技术应该很容易转化为超出本拨款范围的热监测应用。

项目成果

Design and optimization of an ultra wideband and compact microwave antenna for radiometric monitoring of brain temperature.

用于脑温度辐射监测的超宽带紧凑型微波天线的设计和优化。

• 发表时间: 2014-07
• 作者: Rodrigues, Dario B;Maccarini, Paolo F;Salahi, Sara;Oliveira, Tiago R;Pereira, Pedro J S;Limao;Snow, Brent W;Reudink, Doug;Stauffer, Paul R
• 通讯作者: Stauffer, Paul R

Study of the one dimensional and transient bioheat transfer equation: multi-layer solution development and applications.

一维瞬态生物传热方程的研究：多层解的开发和应用。

• 发表时间: 2013-07-01
• 影响因子: 5.2
• 作者: Rodrigues, D B;Pereira, P J S;Limão;Stauffer, P R;Maccarini, P F
• 通讯作者: Maccarini, P F

Physics of thermal therapy: fundamentals and clinical applications.

热疗物理学：基础知识和临床应用。

• 发表时间: 2013-06
• 影响因子: 3.8
• 作者: Moros, E G;Hendee, William R;Stauffer, Paul R
• 通讯作者: Stauffer, Paul R

Design of Small-sized and Low-cost Front End to Medical Microwave Radiometer.

小型低成本医用微波辐射计前端设计。

• 发表时间: 2010
• 作者: Klemetsen, O;Birkelund, Y;Maccarini, P F;Stauffer, P;Jacobsen, S K
• 通讯作者: Jacobsen, S K

Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of brown fat metabolism.

人体组织传热数值 3D 建模，用于微波辐射监测棕色脂肪代谢。

• 发表时间: 2013-02-26
• 作者: Rodrigues, Dario B;Maccarini, Paolo F;Salahi, Sara;Colebeck, Erin;Topsakal, Erdem;Pereira, Pedro J S;Limão;Stauffer, Paul R
• 通讯作者: Stauffer, Paul R