A novel low-cost and noninvasive device to measure deep temperature in the body

一种新型低成本无创设备，用于测量体内深层温度

• 批准号: 8904688
• 负责人: Paolo Francesco Maccarini
• 金额: $ 19.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8904688
• 关键词: Acute; Address; Adhesives; Amplifiers; Anesthesia procedures; Arthritis; Astronomy; Biomedical Research; Brain; Breast Cancer Detection; Brown Fat; Cardiac Surgery procedures; Clinical; Detection; Development; Device or Instrument Development; Devices; Diagnosis; Disease; Disease Progression; Early Diagnosis; Electronics; Elements; Frequencies; Goals; Head; Health; Heart Arrest; Heating; Human; Inflammation; Inflammatory; Inflammatory Response; Injury; Intervention; Liquid substance; Malignant Neoplasms; Mammary Gland Parenchyma; Measurement; Measures; Medical; Medical Research; Medicine; Metabolism; Miniaturization; Modeling; Monitor; Noise; Obesity; Onset of illness; Outcome; Patients; Performance; Phase; Physiological; Physiology; Pilot Projects; Process; Radiometry; Reading; Relative (related person); Research; Resolution; Resources; Scalp structure; Signal Transduction; Skin; Surface; System; Technology; Temperature; Testing; Time; Tissue Model; Tissues; Vision; Wireless Technology; abstracting; analog; base; clinical application; clinical practice; cost; cranium; design; digital; improved; induced hypothermia; injured; innovation; instrument; instrumentation; malignant breast neoplasm; microwave electromagnetic radiation; mind control; multidisciplinary; neuroprotection; novel; prevent; prospective; prototype; response; sensor; tool; tumor metabolism

DESCRIPTION (provided by applicant): Abstract By noninvasively measuring temperature distributions at depth, we could provide new vision of thermal processes occurring in tissues well below the skin surface. An instrument with such ability would respond to many clinical needs, including the monitoring of brain status during cardiac surgery, detect abnormal metabolism in the early formation of aggressive breast cancer, and observe the inflammatory processes in arthritis. Microwave radiometry has been used for many years in astronomy to observe temperature of stars far away. Recent advances in microwave electronics have produced ultra-low noise amplifiers, multilayer compact antennas, and ultra-precise analog-to-digital converters which provide powerful new capabilities for radiometric detection and for the miniaturization of such devices. The proposed instrument development combines these elements to develop a novel array of miniature microwave sensors that will reliably and noninvasively detect small fluctuations in heat emission from deep below the surface of skin. A multidisciplinary team will implement an array of compact, ultrasensitive microwave radiometers mounted directly on deep penetrating antennas. With real-time correlation of radiometric signals from multiple antennas and frequency bands we will reconstruct the thermal distributions at depth several cm below the sensors. We will then demonstrate its potential use in medicine, by comparing in ten patients the head thermal profiles obtained noninvasively by a miniature radiometric array prototype with invasive temperature sensors currently used for long-term monitoring of brain status with traumatic injuries. The proposed thermal imager will enable noninvasive detection of thermal phenomena, such as tumors metabolism in breast tissue or inflammatory response deep below the skin with capabilities that extend far beyond current technology and give us an innovative tool for medical applications.

描述（由申请人提供）：摘要通过非侵入性测量深度温度分布，我们可以提供皮肤表面以下组织中发生的热过程的新视野。具有这种能力的仪器将满足许多临床需求，包括监测心脏手术期间的大脑状态，检测侵袭性乳腺癌早期形成的异常代谢，并观察关节炎的炎症过程。微波辐射测量法在天文学中已使用多年来观测遥远恒星的温度。微波电子学的最新进展已经产生了超低噪声放大器、多层紧凑型天线和超精密模数转换器，为辐射检测和此类设备的小型化提供了强大的新功能。拟议的仪器开发结合了这些元素，开发出一系列新型微型微波传感器，该传感器将可靠且无创地检测皮肤表面深处热发射的微小波动。一个多学科团队将实施一系列直接安装在深穿透天线上的紧凑型超灵敏微波辐射计。通过来自多个天线和频段的辐射信号的实时关联，我们将重建传感器下方几厘米深度的热分布。然后，我们将通过将微型辐射阵列原型无创地获得的头部热分布与目前用于长期监测创伤性脑部状态的侵入式温度传感器进行比较，来展示其在医学上的潜在用途。所提出的热成像仪将能够无创地检测热现象，例如乳腺组织中的肿瘤代谢或皮肤深处的炎症反应，其功能远远超出了现有技术，为我们的医疗应用提供了一种创新工具。