Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism

与毒品市场和毒品旅游相关的丙型肝炎病毒、艾滋病毒和药物过量的民族流行病学

基本信息

批准号：
10619365
负责人：
STEFFANIE A. STRATHDEE
金额：
$ 5.06万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10619365
关键词：
2019-nCoV Abscess Area Automobile Driving Bathing COVID-19 pandemic Cities Coupled Data Data Analyses Data Collection Data Set Defecation Environment Epidemiology Evaluation Funding Goals HIV Hand Handwashing Health Health behavior Hepatitis C Hepatitis C virus Homelessness Housing Human Rights Hygiene Incidence Individual Inequality Injecting drug user Injections Interview Location Mediating Mexico Myocarditis Outcome Overdose Persons Pharmaceutical Preparations Population Prevalence Reporting Research Research Personnel Risk Risk Behaviors SARS-CoV-2 exposure SARS-CoV-2 infection Sanitation Seroprevalences Services Side Soaps Source Surface Toilet Facilities Water Woman Work base drinking water drug market epidemiologic data experience follow-up health disparity improved men metropolitan non-drug parent grant prospective sex sociodemographic group substance use trend vulnerable community wound cleaning

项目摘要

This Diversity Supplement will be conducted based on data obtained from the study Ethno- epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism project (R01DA049644, PI: Strathdee), called La Frontera. The overall goal of the parent grant is to characterize trends in incidence of HIV, HCV, and overdose associated with binational drug markets and drug tourism between San Diego and Tijuana, Mexico. La Frontera conducts prospective quantitative and qualitative surveillance of retail drug markets in both San Diego and Tijuana, coupled with epidemiologic data collection of 600 PWID (200 drug tourists from San Diego; 200 non-drug tourists from San Diego and 200 non-drug tourists from Tijuana). This Diversity Supplement is focused on access to water sanitation and hygiene (WASH) among the population of people who inject drugs (PWID) studied in La Frontera, and is planned to be feasibly conducted in the proposed two-year funding period. Data analyses proposed in this supplement will include data from La Frontera conducted among PWID in the Tijuana and San Diego metropolitan area, which was already collected. This dataset included a six-, 12-, and 18-month follow up during the COVID-19 pandemic, representing a valuable opportunity to assess shifts in health behavior and health risks among PWID in both cities. AIM 1 will describe WASH access at baseline interview, and at 6-month follow-up, among men and women who inject drugs in the Tijuana and San Diego metropolitan area, and by housing status during the COVID-19 pandemic period, from October 2020 to December 2021. AIM 2 will determine if limited access to WASH is associated with higher incidence and prevalence of abscesses in injection locations at over an 18-month follow-up period among PWID in the TJ and SD metropolitan area. AIM 3 will examine if limited access to WASH is associated with higher seroprevalence of SARS-CoV-2 infection among PWID in the Tijuana and San Diego metropolitan area. WASH is a human right and is often violated among vulnerable communities such as PWID, and people experiencing housing insecurity. Although access to WASH services has been poorly studied among PWID, there is ample room for concern, as non-hygienic environments or practices could increase risk of developing abscesses, HIV or Hepatitis C complications, and myocarditis. This supplement offers Dr. Calderon Villarreal a unique opportunity to collaborate and mutually strength the understanding of PWID’s unmet needs and how they are driving poor health outcomes and will support her goal to becoming an independent investigator focusing on the intersection between substance use, WASH and health disparities.

该多样性补充将根据民族研究获得的数据进行与毒品市场和毒品旅游项目相关的丙型肝炎病毒、艾滋病毒和用药过量的流行病学（R01DA049644，PI：Strathdee），称为 La Frontera 家长补助金的总体目标是描述与跨国药品市场相关的艾滋病毒、丙型肝炎和用药过量的发病率趋势圣地亚哥和墨西哥拉弗龙特拉之间的毒品旅游正在进行。对圣地亚哥和蒂华纳零售药品市场进行定量和定性监测收集了 600 名吸毒者的流行病学数据（200 名来自圣地亚哥的吸毒游客；200 名非吸毒游客）来自圣地亚哥的游客和来自蒂华纳的 200 名非毒品游客）。重点关注人民获得水、卫生设施和个人卫生 (WASH) 的机会注射吸毒者 (PWID) 在拉弗龙特拉进行了研究，并计划在本补充材料中提出的拟议的两年资助期数据分析将包括来自的数据。拉弗龙特拉在蒂华纳和圣地亚哥大都市区针对注射吸毒者开展了一项调查，该数据集包括 COVID-19 期间 6 个月、12 个月和 18 个月的随访。大流行，是评估健康行为和健康风险变化的宝贵机会 AIM 1 将在基线访谈和 6 个月时描述 WASH 的获取情况。蒂华纳和圣地亚哥大都市区注射吸毒的男性和女性的后续行动以及 2020 年 10 月至 2021 年 12 月 COVID-19 大流行期间的住房状况。 AIM 2 将确定 WASH 获取机会有限是否与较高的发病率和患病率相关在超过 18 个月的随访期内，TJ 和 SD 注射吸毒者的注射部位出现脓肿 AIM 3 将检查 WASH 获取机会是否与较高水平相关。蒂华纳和圣地亚哥大都市吸毒者中 SARS-CoV-2 感染的血清流行率 WASH 是一项人权，在吸毒者和吸毒者等弱势群体中经常受到侵犯。尽管人们对获得 WASH 服务的情况研究甚少。在注射吸毒者中，有一个样本室值得关注，因为不卫生的环境或做法可能会增加发生脓肿、艾滋病毒或丙型肝炎并发症以及心肌炎的风险。补充品为 Calderon Villarreal 博士提供了独特的合作和相互加强的机会了解注射吸毒者未满足的需求以及它们如何导致不良的健康结果，并将支持她的目标是成为一名独立调查员，专注于药物使用之间的交叉点， WASH 和健康差异。