Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism

与毒品市场和毒品旅游相关的丙型肝炎病毒、艾滋病毒和药物过量的民族流行病学

• 批准号: 10619365
• 负责人: STEFFANIE A. STRATHDEE
• 金额: $ 5.06万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10619365
• 关键词: 2019-nCoV; Abscess; Area; Automobile Driving; Bathing; COVID-19 pandemic; Cities; Coupled; Data; Data Analyses; Data Collection; Data Set; Defecation; Environment; Epidemiology; Evaluation; Funding; Goals; HIV; Hand; Handwashing; Health; Health behavior; Hepatitis C; Hepatitis C virus; Homelessness; Housing; Human Rights; Hygiene; Incidence; Individual; Inequality; Injecting drug user; Injections; Interview; Location; Mediating; Mexico; Myocarditis; Outcome; Overdose; Persons; Pharmaceutical Preparations; Population; Prevalence; Reporting; Research; Research Personnel; Risk; Risk Behaviors; SARS-CoV-2 exposure; SARS-CoV-2 infection; Sanitation; Seroprevalences; Services; Side; Soaps; Source; Surface; Toilet Facilities; Water; Woman; Work; base; drinking water; drug market; epidemiologic data; experience; follow-up; health disparity; improved; men; metropolitan; non-drug; parent grant; prospective; sex; sociodemographic group; substance use; trend; vulnerable community; wound cleaning

This Diversity Supplement will be conducted based on data obtained from the study Ethno- epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism project (R01DA049644, PI: Strathdee), called La Frontera. The overall goal of the parent grant is to characterize trends in incidence of HIV, HCV, and overdose associated with binational drug markets and drug tourism between San Diego and Tijuana, Mexico. La Frontera conducts prospective quantitative and qualitative surveillance of retail drug markets in both San Diego and Tijuana, coupled with epidemiologic data collection of 600 PWID (200 drug tourists from San Diego; 200 non-drug tourists from San Diego and 200 non-drug tourists from Tijuana). This Diversity Supplement is focused on access to water sanitation and hygiene (WASH) among the population of people who inject drugs (PWID) studied in La Frontera, and is planned to be feasibly conducted in the proposed two-year funding period. Data analyses proposed in this supplement will include data from La Frontera conducted among PWID in the Tijuana and San Diego metropolitan area, which was already collected. This dataset included a six-, 12-, and 18-month follow up during the COVID-19 pandemic, representing a valuable opportunity to assess shifts in health behavior and health risks among PWID in both cities. AIM 1 will describe WASH access at baseline interview, and at 6-month follow-up, among men and women who inject drugs in the Tijuana and San Diego metropolitan area, and by housing status during the COVID-19 pandemic period, from October 2020 to December 2021. AIM 2 will determine if limited access to WASH is associated with higher incidence and prevalence of abscesses in injection locations at over an 18-month follow-up period among PWID in the TJ and SD metropolitan area. AIM 3 will examine if limited access to WASH is associated with higher seroprevalence of SARS-CoV-2 infection among PWID in the Tijuana and San Diego metropolitan area. WASH is a human right and is often violated among vulnerable communities such as PWID, and people experiencing housing insecurity. Although access to WASH services has been poorly studied among PWID, there is ample room for concern, as non-hygienic environments or practices could increase risk of developing abscesses, HIV or Hepatitis C complications, and myocarditis. This supplement offers Dr. Calderon Villarreal a unique opportunity to collaborate and mutually strength the understanding of PWID’s unmet needs and how they are driving poor health outcomes and will support her goal to becoming an independent investigator focusing on the intersection between substance use, WASH and health disparities.

这种多样性补充将根据从研究中获得的数据进行。 与药物市场和药物旅游项目相关的HCV，HIV和过量的流行病学 （R01DA049644，PI：Strathdee），称为La Frontera。父母赠款的总体目标是 表征与二进制药物市场相关的艾滋病毒，HCV和用药过量的趋势 以及墨西哥圣地亚哥和蒂华纳之间的毒品旅游。 La Frontera进行潜在的 圣地亚哥和蒂华纳的零售药物市场的定量和定性监视，耦合 随着600个PWID的流行病学数据收集（来自圣地亚哥的200名毒品游客； 200个非毒品 来自圣地亚哥的游客和蒂华纳的200名非毒品游客）。这种多样性补充是 专注于在人群中获得水卫生和卫生（WASH） 谁注射药物（PWID）在La Frontera学习，并计划在 拟议的两年资金期。此补充中提出的数据分析将包括来自 La Frontera在蒂华纳和圣​​地亚哥都会区的PWID中进行 已经收集了。该数据集包括19日期间的六个月，12个和18个月的随访 大流行，代表了评估健康行为和健康风险转变的宝贵机会 在两个城市的PWID中。 AIM 1将描述在基线面试中的WASH访问，并在6个月中描述 在蒂华纳和圣​​地亚哥都会区注入毒品的男性和女人中， 从2020年10月至2021年12月，在19日大流行期间的住房状况。 AIM 2将确定有限的WASH访问是否与更高的事件和患病率有关 在TJ和SD中PWID的18个月后随访期间，注射位置的脓肿在 大都市地区。 AIM 3将检查是否有限的洗涤途径与较高的访问有关 蒂华纳和圣​​地亚哥大都会的PWID中SARS-COV-2感染的血清阳性感染 区域。 Wash是一项人权，经常在PWID等脆弱社区中受到侵犯， 经历住房不安全感的人。尽管可以使用Wash服务，但研究效果很差 在PWID中，有足够的关注空间，因为非Y型环境或实践可以 增加患脓肿，艾滋病毒或丙型肝炎并发症和心肌炎的风险。这 补充剂为Calderon Villarreal博士提供了一个独特的机会，可以合作并相互加强 了解PWID未满足的需求以及它们如何推动健康状况不佳，并将支持 她成为一名独立研究人员的目标，专注于物质使用之间的交集， 洗涤和健康差异。