Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism

与毒品市场和毒品旅游相关的丙型肝炎病毒、艾滋病毒和药物过量的民族流行病学

基本信息

批准号：
10704856
负责人：
STEFFANIE A. STRATHDEE
金额：
$ 54.75万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10704856
关键词：
Address Border Community Characteristics Cities Cocaine Country Coupled Data Data Collection Disease Outbreaks Drug Formulations Drug Prescriptions Epidemiology Ethnography Female Fentanyl Future Geography HIV HIV/HCV Half-Life Health Heating Helping to End Addiction Long-term Hepatitis C Incidence Hepatitis C virus Heroin Incidence Injecting drug user Injections Intervention Laws Lead Mediating Methamphetamine Mexico Modeling Molecular Epidemiology Monitor National Institute of Drug Abuse Needle Sharing Outcome Overdose Penetration Persons Pharmaceutical Preparations Powder dose form Price Reporting Research Risk Behaviors Route Sampling Syringes Tars Testing Time United States National Institutes of Health Virus cohort drug market epidemiologic data male mathematical model non-drug prescription opioid prevent preventive intervention prospective trafficking transmission process trend

项目摘要

This competitive revision aims to increase access and uptake of COVID-19 testing and vaccination among people who inject drugs (PWID), a population highly vulnerable to COVID-19. The proposed RADxUP project, LinkUP, will be nested within the San Diego component of our parent grant, La Frontera, which was funded by NIDA in 04/20. To date, 31% of La Frontera PWID have tested SARS- CoV-2 antibody+, of whom 65% had not previously been tested for COVID-19. Only 3% had been vaccinated by 05/2021 and 45% were vaccine hesitant. Our specific aims are: AIM 1. To prospectively evaluate the prevalence, predictors and barriers to COVID-19 testing among PWID. AIM 2. To prospectively assess incidence, predictors and barriers to COVID-19 vaccination among PWID. AIM 3. To adapt and pilot an intervention offered at a mobile syringe services program (SSP) to improve uptake of COVID-19 testing and vaccination among PWID. AIM 4. To compare COVID testing and vaccination rates before and after the state introduces a) COVID-19 rapid testing and b) COVID-19 vaccination at the SSP, which represents a natural experiment. AIM 5. To prospectively assess the impact of COVID-19 testing and vaccination on PWIDs’ behaviors. To meet Aim 1 and 2, we will conduct interviews with 400 PWID in La Frontera, results which will be available in Fall 2021. Based on these findings and input from our Community and Scientific Advisory Board (CSAB), we will select and adapt a brief intervention to improve COVID-19 testing and vaccination uptake among PWID at the mobile van of our community partner, OnPoint. The LinkUP intervention will then be piloted among a subgroup of 150 La Frontera PWID who have not received COVID-19 vaccine or testing and will be implemented by OnPoint peer counsellors, who will also offer on-site rapid COVID-19 antigen testing and confirmatory PCR and referrals to the closest COVID-19 vaccination center (until vaccine is offered at OnPoint by the state). We will evaluate COVID-19 vaccine uptake independently through ongoing La Frontera study visits that will include self-reported interview data, linkage of electronic health records with the San Diego County COVID-19 database, and by analyzing SARSCoV-2 antibody patterns to differentiate between natural infection and vaccine-induced immunity. Results will be used to estimate effect sizes for a future efficacy trial and shared with the RADxUP consortium, policymakers and program planners. Since there are 185 SSPs across the country, our study will inform efforts to enable SSPs to become important ‘touchpoints’ to reach marginalized PWID, strengthening the nation’s pandemic preparedness infrastructure to reduce COVID-19 health disparities.

这种竞争性修订旨在增加COVID-19测试和疫苗接种的访问和吸收在注射毒品（PWID）的人中，这是一个高度容易受到Covid-19的人口。提议 RADXUP项目Linkup将嵌套在我们父母赠款的圣地亚哥组成部分中 Frontera，由NIDA在04/20资助。迄今为止，La Frontera PWID的31％已经测试了SARS- COV-2抗体+，其中65％以前未曾测试过COVID-19。只有3％接种疫苗05/2021和45％的疫苗犹豫。我们的具体目的是：目标1。评估PWID中COVID-19测试的患病率，预测因素和障碍。目标2 前瞻性评估PWID中COVID-19疫苗接种的预测因素和障碍。目标3。适应和试行一项移动注射服务计划（SSP）提供的干预措施以改进 PWID中的COVID-19测试和疫苗接种的吸收。目的4。比较互联测试和国家引入之前和之后的疫苗接种率a）COVID-19-19 SSP的疫苗接种，代表自然实验。目标5。前瞻性评估 COVID-19测试和疫苗接种对PWIDS行为的影响。要满足目标1和2，我们将在La Frontera进行400个PWID进行访谈，结果将于2021年秋季提供。我们社区和科学顾问委员会（CSAB）的这些发现和意见，我们将选择和选择调整简短的干预措施，以改善PWID的COVID-19测试和疫苗接种的摄入我们社区合作伙伴的移动货车Onpoint。然后将在尚未接受Covid-19疫苗或测试的150个La Frontera PWID的亚组由Onpoint同伴辅导员实施，他们还将提供现场快速Covid-19抗原测试和确认性PCR和转介到最近的Covid-19-19疫苗中心（直到提供疫苗在国家 /地区）。我们将通过正在进行的LA独立评估COVID-19疫苗摄取 Frontera研究访问将包括自我报告的访谈数据，电子健康记录的链接与圣地亚哥县COVID-19数据库，并通过分析SARSCOV-2抗体模式区分自然感染和疫苗诱导的免疫力。结果将用于估计未来有效性试验的效应大小，并与Radxup联盟，决策者和计划计划者。由于全国有185个SSP，我们的研究将为实现 SSP成为重要的“接触点”，以达到边缘化的PWID，从而加强了国家的大流行准备基础设施以减少19. COVID-19的健康分配。