Pathology and Biorepository

病理学和生物样本库

• 批准号: 8340242
• 负责人: KEVIN J. CULLEN
• 金额: $ 6.67万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-24 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340242
• 关键词: Anatomy; Archives; Baltimore; Biology; Cancer Center; Cancer Center Support Grant; Clinical Investigator; Confidentiality of Patient Information; Consultations; Databases; Diagnosis; Diagnostic; Effectiveness; Ensure; Evaluation; Formalin; Freezing; Genomics; Histology; Image Analysis; Institutional Review Boards; Instruction; Knowledge; Laboratories; Lesion; Libraries; Maryland; Mission; Normal tissue morphology; Operative Surgical Procedures; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Preparation; Proteomics; Research; Research Personnel; Resources; Retrieval; Sampling; Services; Specimen; Surgical Pathology; Techniques; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translating; Tumor Pathology; Universities; base; biobank; clinical application; digital imaging; experience; human tissue; protocol development; success; tissue processing; tumor

PROJECT SUMMARY (See instructions): The Pathology and Biorepository Shared Service (PBSS) at the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) has two main missions: (1) provide access to a consistently excellent quality of banked patient samples (tissue and other preparations) while maintaining patient confidentiality and (2) provide pathology, histology, and histotechnology consultation services to assist clinical investigators in the procurement, analyses, and clinicopathologic correlation of human tissue specimens. Through access to tissue specimens, investigators can perform analyses (e.g., genomic or proteomic studies) to understand the biology of normal and diseased tissues and then translate that knowledge for diagnostic and clinical applications. PBSS is the only tissue bank shared service for specimens removed at surgery at the University of Maryland-Baltimore (UMB) campus. PBSS has an integrated relationship with the Division of Anatomic Pathology of the Department of Pathology, which is essential for obtaining well-characterized tissue samples and pathology and histology expertise. In addition to the ongoing banking of all sold tumors,PBSS also provides investigator-specific tissue procurement and processing; access to more than 7,000 frozen tumor samples, of which 5,900 are paired with normal tissue from the same patient; and access to the formalin-fixed paraffin-embedded (FFPE) specimen archive of the Anatomic Pathology Laboratory, which consists of more than 1,260,000 FFPE tissue blocks with various pathologic diagnoses. PBSS performs searches of the frozen sample library and the surgical pathology archive for sets of specific samples, with subsequent retrieval of specimens and confirmation ofthe presence of relevant lesion/tumor by Drs. Olgaloffe or William Twaddell. The provision of clinicopathologic parameters is available upon request, depending on the specific research question. PBSS staff possess extensive experience with a wide range of techniques and specimen types. PBSS offers consultation with pathologists for protocol development and tissue evaluation; Institutional Review Board issues; technical support; and expertise for routine histological and immunohistochemical analyses of research specimens, digital image analysis, and tissue microarray construction. The success and effectiveness of PBSS is based on its ability to integrate its pathology and biorepository resources and expertise into research being conducted at UMGCC.

项目摘要（参见说明）： 马里兰大学马琳和斯图尔特格林鲍姆癌症中心 (UMGCC) 的病理学和生物样本库共享服务 (PBSS) 有两个主要使命：(1) 提供始终如一的优质存储患者样本（组织和其他制剂），同时保持患者保密；(2) 提供病理学、组织学和组织技术咨询服务以协助临床研究人员 人体组织标本的采购、分析和临床病理学相关性。通过获取组织样本，研究人员可以进行分析（例如基因组或蛋白质组研究），以了解正常和患病组织的生物学，然后将这些知识转化为诊断和临床应用。 PBSS 是唯一的组织库共享服务，用于在手术中取出的标本 马里兰大学巴尔的摩分校 (UMB) 校园。 PBSS 与病理学系解剖病理学部门有着密切的合作关系，这对于获得充分表征的组织样本以及病理学和组织学专业知识至关重要。除了持续存储所有出售的肿瘤外，PBSS 还提供研究者特定的组织采购和处理；访问超过 7,000 冷冻肿瘤样本，其中 5,900 个与同一患者的正常组织配对；以及访问解剖病理学实验室的福尔马林固定石蜡包埋 (FFPE) 标本档案，其中包含超过 1,260,000 个具有各种病理诊断的 FFPE 组织块。 PBSS 对冷冻样本库和外科病理学档案进行搜索以查找特定样本组，其中 随后，Drs 取回标本并确认相关病变/肿瘤的存在。奥尔加洛夫或威廉·特瓦德尔。根据具体研究问题，可根据要求提供临床病理学参数。 PBSS 工作人员拥有广泛技术的丰富经验 和标本类型。 PBSS 为方案制定和组织评估提供与病理学家的咨询；机构审查委员会问题；技术支援;以及研究标本的常规组织学和免疫组织化学分析、数字图像分析和组织微阵列构建的专业知识。 PBSS 的成功和有效性取决于其整合病理学和病理学的能力 UMGCC 正在进行的研究的生物样本库资源和专业知识。