Developing research training in Zambia to address the epidemic of cardiovascular disease and mental illness amongst HIV infected populations.

在赞比亚开展研究培训，以解决艾滋病毒感染人群中心血管疾病和精神疾病的流行问题。

• 批准号: 10243738
• 负责人: Carolyn Bolton
• 金额: $ 3.24万
• 依托单位: CENTRE FOR INFECTIOUS DISEASE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10243738
• 关键词: Address; Aging; COVID-19 outbreak; Cardiovascular Diseases; Caring; Collaborations; Comprehensive Health Care; Congestive Heart Failure; Country; Data; Diabetes Mellitus; Enrollment; Epidemic; Funding; Goals; Grant; HIV; HIV-1; Health; Heart Diseases; Improve Access; Indigenous; Individual; Institution; Investments; Life Expectancy; Medical; Mental Health; Mental disorders; Morbidity - disease rate; Myocardial Infarction; Population; Prevalence; Principal Investigator; Research; Research Personnel; Research Training; Resources; Risk Factors; SARS-CoV-2 infection; Services; Specificity; Training; Training Programs; Universities; Washington; Woman; Zambia; antiretroviral therapy; authority; care providers; comorbidity; dissemination strategy; hypertensive heart disease; implementation strategy; low and middle-income countries; men; mortality; treatment program

Project Summary/Abstract: The overarching goal of this D71 planning grant is to develop a D43 research-training program in cardiac disease and mental illness amongst HIV infected individuals enrolled in the National HIV Care and Treatment Program in Zambia. In 2018, 1.2 million people in Zambia were living with HIV1. In 2016, life expectancy for men was 60 years and for women 64 years, a considerable increase from 49.4 years in 2012, partly due to improved access to antiretroviral treatment (ART). 2 However, despite the considerable increase in life expectancy, mortality amongst the HIV infected population remains significant. Non-communicable diseases (NCDs), in particular cardio-vascular disease (incorporating hypertensive heart disease, myocardial infarction and congestive cardiac failure), aging and mental illness are increasingly responsible for high morbidity and mortality in low- and middle- income countries (LMICs) such as Zambia. CIDRZ, an indigenous research organization in Zambia, has been leading the efforts to establish and maintain high quality, comprehensive care for HIV infected individuals across the country. The significant investment into HIV services (including PEPFAR) have resulted in a cadre of well trained, skilled and confident HIV care providers and clinicians. However, the specificity of their training has meant that there is a dearth of trained researchers and investigators to identify the relevant research questions and also a shortage of competent and trained clinicians to deal with significant co- morbidities including diabetes, cardiovascular disease, aging and, of note, mental health issues. More recently, these gains are being eroded by the outbreak of SARS-CoV-2 infection whose impact on HIV-infected individuals particularly in our resource constrained setting remains unknown. CIDRZ, in collaboration with Washington University in St. Louis, proposes to partner with the University of Zambia, the University of Lusaka, Levy Mwanawasa Medical University, the Ministry of Health, and the National Health Research Authority to establish a training platform for ongoing high-quality HIV/ NCD research. We are requesting funding under this D71 to prepare for, and ultimately construct, a D43 that would aim to: 1. Increase the pool of qualified, competent researchers and principal investigators; 2. Increase and enhance locally-generated NCDs prevalence and risk factor data amongst HIV infected individuals; 3. develop dissemination and implementation strategies and 4. Develop collaborations with other research institutions and universities both locally and within the sub-region to leverage off current capacity and enhance the research capability.

项目摘要/摘要：该D71计划赠款的总体目标是开发一个 D43心脏病和精神疾病的研究培训计划感染了 在赞比亚参加国家艾滋病毒护理和治疗计划的个人。在2018年， 赞比亚有120万人与HIV1住在一起。 2016年，男性的预期寿命为60 年份和64岁的女性，比2012年的49.4岁有了可观的增长，部分原因是 改善抗逆转录病毒治疗（ART）的机会。 2但是，尽管有很多 预期寿命的增加，艾滋病毒感染人群中的死亡率仍然显着。 非传染性疾病（NCD），特别是心血管疾病（合并 高血压心脏病，心肌梗塞和充血性心脏衰竭），衰老和 精神疾病越来越负责低和中间的高发病和死亡率 收入国家（LMIC），例如赞比亚。 Cidrz，一家土著研究组织 赞比亚一直在领导建立和维持高质量，全面的努力 照顾全国艾滋病毒感染的人。对艾滋病毒的重大投资 服务（包括pepfar）导致了一群训练有素，熟练和自信的干部 HIV护理提供者和临床医生。但是，他们培训的特异性意味着 缺乏训练有素的研究人员和研究人员来确定相关研究 问题以及缺乏能力和训练有素的临床医生来处理重要的合作 包括糖尿病，心血管疾病，衰老和心理健康在内的病态 问题。最近，SARS-COV-2感染爆发了这些收益正在侵蚀 他们对感染艾滋病毒感染者的影响，特别是在我们的资源限制环境中 仍然未知。 Cidrz与圣路易斯华盛顿大学合作，提议 要与赞比亚大学，卢萨卡大学列维·姆瓦纳瓦萨医学合作 大学，卫生部和国家卫生研究局建立一个 持续高质量艾滋病毒/ NCD研究的培训平台。我们在要求资金 这款D71准备并最终构建的D43，其目的是：1。增加池 合格的，有能力的研究人员和主要研究人员； 2。增加和增强 局部生成的NCDS患病率和危险因素数据在受HIV感染的个体中； 3。 制定传播和实施策略和4。与其他 研究机构和大学在本地和子区域内都利用 当前能力并增强研究能力。