A Population-Based Latinx Community Study of Alzheimer’s Disease

基于人群的阿尔茨海默氏病拉丁裔社区研究

• 批准号: 10730066
• 负责人: Kristin R Krueger
• 金额: $ 55.34万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730066
• 关键词: Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Behavioral; Biological; Biological Markers; Black race; Blood; Blood specimen; COVID-19; COVID-19 impact; COVID-19 outbreak; COVID-19 pandemic effects; Censuses; Chicago; Clinical; Cohort Studies; Collection; Communities; Community Outreach; Data; Data Collection; Death Rate; Dementia; Elderly; Epidemic; Ethnic Origin; Ethnic Population; Event; Exhibits; Focus Groups; Future; Genetic; Goals; Grant; Growth; Health; Health system; Height; High Prevalence; Hispanic; Hispanic Populations; Household; Impaired cognition; Incidence; Individual; Infrastructure; Knowledge; Latinx; Latinx population; Life Style; Minority; Minority Groups; Neighborhoods; Not Hispanic or Latino; Participant; Pathology; Perception; Persons; Phase; Population; Population Study; Prevalence; Prevention strategy; Procedures; Protocols documentation; Public Health; Race; Recommendation; Research; Research Infrastructure; Research Project Grants; Resource Sharing; Resources; Risk; Risk Factors; Sampling; Side; Testing; U-Series Cooperative Agreements; United States National Institutes of Health; Update; Washington; apolipoprotein E-4; biracial; cardiovascular risk factor; clinical diagnosis; cognitive function; cognitive testing; cohort; community organizations; design; experience; health determinants; health inequalities; human old age (65+); improved; infection rate; member; mild cognitive impairment; minority health; minority health disparity; multi-ethnic; nervous system disorder; novel; population based; population health; psychologic; psychosocial; racial difference; racial population; recruit; research study; social; social determinants; success; tool; web site

ABSTRACT Older Latinx adults in the US are at a greater risk of developing Alzheimer's disease (AD) and related dementias (ADRD). They exhibit a faster cognitive decline than non-Hispanic whites. However, they remain vastly underrepresented in research studies to characterize risk factors associated with progressive cognitive decline. A better understanding of risk factors can provide better treatment and design appropriate preventive strategies for older Latinx adults. Since older Latinx adults have a higher prevalence of cardiovascular risk factors, their risk of developing ADRD is high in old age. Older Latinx communities were disproportionately affected by the COVID-19 pandemic, which can increase their risk for neurological disorders. This UH2/UH3 cooperative agreement aims to engage and develop the infrastructure for a new Latinx cohort study with the following aims: (1) build infrastructure, community outreach, and the external advisory board for a new Latinx cohort; (2) develop ongoing engagement with the community and resource sharing plan; (3) collect data on 250 Latinx participants from East Side sampling frame; and (4) test the exploratory hypotheses that Latinx participants have a higher prevalence of clinically diagnosed AD and MCI, and the impact of COVID-19 on AD is more severe compared to non-Hispanic whites, and the ApoE4 association with clinical AD and MCI is the same as NHW. The long-term objective is to perform a sizeable muti-ethnic study, combining the Latinx cohort with our existing Chicago Health and Aging Project (CHAP), a population-based community study in four neighborhoods with 10,801 participants with 63% non-Hispanic Black and 37% non-Hispanic white participants. This UH2/UH3 proposal will add a new Latinx cohort in the East Side community of Chicago, with over 60% Latinx. A multi-ethnic cohort will allow us to test several biological and psychosocial hypotheses of high public health significance. The collection of biospecimens will also allow for testing further blood biomarker hypotheses, developing an omics pipeline down the road, and providing additional infrastructure for pathology studies in a population-based cohort study with minorities.

抽象的 美国年龄较大的拉丁裔成年人患阿尔茨海默氏病（AD）和相关的风险更大 痴呆症（ADRD）。与非西班牙裔白人相比，它们表现出更快的认知能力下降。但是，它们仍然存在 在研究中的人为大大不足，无法表征与进行性认知相关的危险因素 衰退。更好地了解风险因素可以提供更好的治疗和设计适当的预防性 年龄较大的拉丁裔成年人的策略。由于年龄较大的拉丁裔成年人的心血管风险患病率更高 因素，他们患ADRD的风险在老年中很高。较旧的拉丁裔社区不成比例 受共同-19大流行的影响，可以增加其神经系统疾病的风险。这个UH2/UH3 合作协议旨在参与和开发与新拉丁裔队列研究的基础设施 以下目的：（1）建立基础设施，社区外展和新拉丁裔的外部顾问委员会 队列； （2）与社区和资源共享计划进行持续的参与； （3）收集数据 来自东侧采样框架的250名拉丁裔参与者； （4）测试拉丁裔的探索假设 参与者的临床诊断为AD和MCI的患病率更高，Covid-19对AD的影响 与非西班牙裔白人相比，更严重，而APOE4与临床AD和MCI的关联是 与NHW相同。长期目的是进行大量的族裔研究，结合拉丁裔队列 借助我们现有的芝加哥卫生与老化项目（CHAP），这是一项基于人群的社区研究 有10,801名参与者的社区，有63％的非西班牙裔黑人和37％的非西班牙裔白色 参与者。该UH2/UH3提案将在芝加哥东区社区增加一个新的拉丁裔队列，并与 超过60％的拉丁裔。多种族的队列将使我们能够检验几种生物学和社会心理假设 高公共健康意义。生物测量的收集也将允许进一​​步测试血液 生物标志物假设，在道路上开发一条OMICS管道，并提供其他基础设施 与少数民族的基于人群的队列研究中的病理研究。