Impact of COVID-19 on AD Occurrence: A Biracial Intergenerational Population Study

COVID-19 对 AD 发生的影响：一项双种族代际人口研究

• 批准号: 10634628
• 负责人: NEELUM T. AGGARWAL
• 金额: $ 263.99万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10634628
• 关键词: 2019-nCoV; Acute; Address; Administrative Supplement; African American population; Age; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Antibodies; Area; Award; Biological Markers; Blood; Blood Vessels; Body mass index; Brain Injuries; COVID-19; COVID-19 impact; COVID-19 outbreak; COVID-19 risk; Censuses; Chicago; Chronic; Clinical; Cognition; Cognitive; Communities; Death Rate; Dementia; Diffusion Magnetic Resonance Imaging; Disease Outbreaks; Elderly; Environment; Epidemiology; Ethnic Origin; European; Family; Female; Gender; Generations; Goals; Health; Hippocampus; Hypertension; Immunity; Impaired cognition; Impairment; Incidence; Individual; Infarction; Infection; Inflammatory; Life Style; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Minority; Outcome; Parents; Participant; Pattern; Population; Population Heterogeneity; Population Study; Prevalence; Prevention strategy; Preventive; Public Health; Publishing; RNA; Race; Reporting; Research; Risk; Risk Factors; Role; SARS-CoV-2 infection; SARS-CoV-2 transmission; Sampling; Serology; Social Characteristics; Social Distance; Testing; Therapeutic; Therapeutic Studies; White Matter Hyperintensity; Woman; Work; aging brain; biracial; brain health; clinical diagnosis; cognitive testing; cohort; coronavirus disease; cytokine; dementia risk; demographics; genetic risk factor; high risk; high risk parents; human old age (65+); infection rate; inflammatory marker; innovation; intergenerational; long term consequences of COVID-19; male; middle age; neuroimaging; novel; offspring; parent project; population based; population health; post-COVID-19; racial disparity; racial minority; research clinical testing; sex; social; social disparities; social engagement; statistics; trend; vascular risk factor

The Chicago Health and Aging Project (CHAP) has made several significant contributions to Alzheimer's disease and related dementias (ADRD) epidemiology. These areas include racial disparities, prevalence, and incidence of dementia trends, social, lifestyle, vascular, genetic risk factors, and neuroimaging and blood biomarkers in a large population-based community study of African Americans (AAs) and European Americans (EAs). Using the older CHAP parent and the ongoing midlife offspring cohorts, we will test several novel and innovative hypotheses on the impact of COVID-19 on ADRD, MCI, cognitive decline, and structural MRI brain injury. By extending the awarded NIA NOSI Administrative Supplement, the intergenerational study provides significant advantages by investigating: (1) the direct effect of SARS-CoV-2 infections amongst those with higher inflammatory cytokines, especially in families with a high risk of COVID-19 transmission, which leads to adverse cognitive outcomes; and (2) an indirect effect of COVID-19 outbreak-imposed changes in physical and cognitive activities, social engagement, and vascular risk factors in a shared family environment in diverse communities. To address this scientific area of research, we propose to conduct a biracial population-based community study of 4,000 older CHAP parents with two population cognitive assessments and detailed clinical evaluations for ADRD in 1,200 participants with the following specific aims: (1) Estimate the 2020 US census demographic adjusted overall and demographic-specific (age, race/ethnicity, and gender) prevalence and incidence of ADRD, MCI, and dementia likelihood and test whether the prevalence and incidence have changed before and after COVID-19. Also, test whether the 5-year risk of ADRD among high-risk AA parents has high-risk offspring compared to EAs; (2) Examine the change in physical and cognitive activities, social engagement, BMI, and hypertension from pre- to post-COVID and the impact of these changes on the risk of ADRD, MCI, cognitive decline, and MRI brain injury. Also, test whether these associations are higher by age, sex (males vs. females), and among AA parents and offspring compared to EA parents and offspring; (3) Test whether participants with SARS-CoV-2 RNA infections and serology antibodies and elevated concentrations of inflammatory cytokines among those with higher vascular risk factors have a higher risk of ADRD, MCI, cognitive decline, and structural MRI brain injury. Also, test whether these associations are higher among AA parents and offspring compared to EAs. This proposal has an enormous public health impact in developing preventive strategies and therapeutic studies on the impact of COVID-19 on population health across generations from midlife to late-life in a diverse population with socially disadvantaged AA minorities.

芝加哥卫生与衰老项目（CHAP）为阿尔茨海默氏症做出了一些重大贡献 疾病和相关痴呆症（ADRD）流行病学。这些领域包括种族差异，患病率和 痴呆趋势，社会，生活方式，血管，遗传危险因素以及神经成像和血液的发病率 大型基于人群的非洲裔美国人（AAS）和欧洲美国人的生物标志物 （EAS）。使用年长的Chap父母和正在进行的中年后代同伙，我们将测试几本小说和 创新的假设对COVID-19对ADRD，MCI，认知能力下降和结构MRI脑的影响 受伤。通过扩展授予的NIA NOSI行政补充，代际研究提供了 通过研究的显着优势：（1）SARS-COV-2感染的直接影响 炎性细胞因子，特别是在Covid-19传播高风险的家庭中，导致不良 认知结果； （2）Covid-19-19-19 在不同社区共享家庭环境中的活动，社会参与和血管风险因素。 为了解决这一科学研究领域，我们建议进行基于混血的人群社区研究 有两个人口认知评估和详细的临床评估的4,000名年龄较大的伙伴父母 在1200名参与者中，ADRD具有以下特定目的：（1）估计2020年美国人口普查人口 经过调整的整体和人口特异性（年龄，种族/种族和性别）ADRD的患病率和发病率， MCI和痴呆症的可能性和痴呆症的可能性和发病率是否发生了变化 新冠肺炎。另外，测试高风险AA父母中ADRD的5年风险是否具有高风险后代 与EA相比； （2）检查身体和认知活动，社会参与，BMI和 从前到杂化后的高血压以及这些变化对ADRD，MCI，认知风险的影响 下降和MRI脑损伤。另外，测试这些关联是否逐年较高，性别（男性与女性）， 与EA父母和后代相比，在AA父母和后代中； （3）测试参与者是否与 SARS-COV-2 RNA感染和血清学抗体以及炎症细胞因子浓度升高 在具有较高血管危险因素的患者中，ADRD的风险较高，MCI，认知下降和结构性较高 MRI脑损伤。另外，与AA父母和后代相比，测试这些关联是否更高 EAS。该建议在制定预防策略和治疗方面具有巨大的公共卫生影响 研究Covid-19对从中年到后期世代相传的人口健康的影响的研究 社会弱势群体的人口少数群体。