Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) of the Cooperative Human Tissue Network (CHTN)

人体组织合作网络 (CHTN) 的阿巴拉契亚和五大湖研究生物样本资源 (AGL-RBR)

• 批准号: 10599185
• 负责人: Anil V Parwani
• 金额: $ 70.95万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-09 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10599185
• 关键词: Accounting; Adult; Age; Appalachian Region; Basic Science; Benign; Biocompatible Materials; Biological Markers; Biological Sciences; Body Fluids; Cancer Hospital; Caring; Clinical; Clinical Data; Code; Collection; Communities; Comprehensive Cancer Center; Computerized Medical Record; Consent; Cooperative Human Tissue Network; Custom; Data; Data Collection; Data Set; Database Management Systems; Databases; Diagnosis; Disease; Elements; Ethnic Origin; Fees; Future; Gender; Geographic Locations; Geography; Growth; Health; Hospitals; Human; Immunohistochemistry; Informatics; Institutional Review Boards; International; Journals; Knowledge; Laboratories; Link; Liquid substance; Malignant - descriptor; Malignant Neoplasms; Medical; Medical Research; Medical center; Methods; Microscopy; Molecular; National Cancer Institute; New York; Ohio; Participant; Pathologist; Pathology; Pathology Report; Patients; Pennsylvania; Performance; Population; Privacy; Protocols documentation; Quality Control; Race; Reporting; Research; Research Personnel; Resources; Science; Scientific Advances and Accomplishments; Services; Shipping; Site; Testing; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Universities; University Hospitals; biobank; bioinformatics infrastructure; cancer care; cancer therapy; common rule; digital; experience; human tissue; improved; innovation; interest; meetings; novel; personalized medicine; preservation; programs; recruit; research study; sample collection; translational cancer research; translational scientist; tumor

PROJECT SUMMARY/ABSTRACT This proposal organizes the resources and experience of the Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) for participation as an Adult Division of the NCI Cooperative Human Tissue Network (CHTN). Our AGL-RBR group of pathologists is equipped to efficiently provide remnant patient consented biospecimens for basic and early translational cancer research as well as for biomarker research studies to support personalized medicine. The Ohio State University (OSU) Hospital and James Cancer Hospital in Columbus, OH will function as the Coordinating/Procurement Center while University Hospitals Cleveland Medical Center, Cleveland, OH, University at Buffalo hospital affiliations, Buffalo, NY and University of Pittsburgh Medical Center Shadyside, Pittsburgh, PA and associated hospitals will function as geographically distributed Procurement/Biorepository sites. The OSU Coordinating Center- Investigator Management Service will manage the investigator applications and approvals and investigator biospecimen request networking. The OSU Biospecimen Management Service will handle the tissue Quality Control, biospecimen storage and shipping and CHTN fee billing, collections and monthly accounting. Tissue Procurement supports custom biospecimen collection including investigator provided novel preservation fluids or methods. Available informatics support collection of data related to donor consents, biospecimens, investigators and billing. Shipped biospecimens include a redacted Pathology and QC Report for each biospecimen shipped. Pathology Reports at OSU for freshly procured tissues include clinically appropriate molecular testing. Investigators may also request, if IRB approved, extensive clinical data available from the OSU Information Warehouse (IW) and additional laboratory testing such as immunohistochemistry, tissue microarray construction, digital microscopy or digital morphometrics. Biospecimen donor privacy and confidentiality are essential elements of the AGL-RBR biospecimen management proposal so that all procured biospecimens are patient consented and coded. Delinking is available for special tissues that were not consented at procurement. The OSU procurement program joined the OSU Comprehensive Cancer Center (OSUCCC) in deploying the Total Cancer Care® (TCC) protocol in 2016 to provide comprehensive donor consent. Donors who consent give full use for future research all of their past, present and future remnant biomaterials to IRB approved researchers. Procurement/Biorepository sites have similar consent programs in place. Scientific or technical knowledge or discoveries acquired in the conduct of our tissue procurement/preservation program will be reported at national and international scientific and technical meetings to contribute to the growth of biospecimen science, to recruit new investigators who have research interests best served by human biospecimen research and to inform the research community and public.

项目摘要/摘要 该建议组织阿巴拉契亚和大湖研究的资源和经验 作为NCI合作人组织的成人划分参与的BiospeCemen Resource（AGL-RBR） 网络（CHTN）。我们的AGL-RBR病理学家组等于有效提供残留患者 基本和早期翻译癌症研究以及生物标志物研究的同意生物测量 支持个性化医学的研究。俄亥俄州立大学（OSU）医院和詹姆斯癌症 俄亥俄州哥伦布医院将充当协调/采购中心 克利夫兰医学中心，俄亥俄州克利夫兰，纽约州布法罗的布法罗医院分支机构大学和大学 宾夕法尼亚州匹兹堡的匹兹堡医学中心Shadyside和相关医院将充当 地理分布的采购/生物座位地点。 OSU协调中心调查员 管理服务将管理调查员的应用程序和批准和研究者生物测试 请求网络。 OSU BioseCemen管理服务将处理组织质量控制， 生物环境存储和运输以及CHTN费用帐单，收款和每月会计。组织 采购支持定制的生物循环收集，包括调查员提供了新颖的保存液 或方法。可用信息支持收集与捐赠者同意有关的数据，生物测量， 调查人员和计费。已发货的生物测量包括每种的编辑病理和质量控制报告 Biospecimen运输。 OSU的病理报告新鲜采购的组织包括临床上适当的 分子测试。如果IRB批准了大量的临床数据，调查人员还可以要求 OSU信息仓库（IW）和其他实验室测试，例如免疫组织化学，组织 微阵列结构，数字显微镜或数字形态计量学。生物环enen供体隐私和 机密性是AGL-RBR生物探测管理建议的基本要素，因此所有人都采购 生物测量是患者同意和编码的。链接可用于特殊的时间安排 在采购中同意。 OSU采购计划加入了OSU综合癌症中心 （OSUCCC）在2016年部署TotalCancerCare®（TCC）方案时提供全面的捐助者 同意。同意完全使用的捐助者将来所有过去，现在和将来的残余 生物材料向IRB批准的研究人员。采购/生物座位网站在 地方。在我们组织的行为中获得的科学或技术知识或发现 采购/保护计划将在国家和国际科学和技术 会议为生物循环科学的成长做出贡献，招募有研究的新调查员 人类生物循环研究最有利于利益，并为研究界和公众提供信息。