Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) of the Cooperative Human Tissue Network (CHTN)

人体组织合作网络 (CHTN) 的阿巴拉契亚和五大湖研究生物样本资源 (AGL-RBR)

• 批准号: 10379285
• 负责人: Anil V Parwani
• 金额: $ 70.86万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-09 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379285
• 关键词: Accounting; Adult; Appalachian Region; Basic Science; Benign; Biocompatible Materials; Biological Markers; Biological Sciences; Buffaloes; Cancer Hospital; Caring; Clinical; Clinical Data; Code; Collection; Communities; Comprehensive Cancer Center; Computerized Medical Record; Consent; Cooperative Human Tissue Network; Custom; Data; Data Collection; Data Set; Database Management Systems; Databases; Diagnosis; Disease; Elements; Ethnic Origin; Fees; Future; Gender; Geographic Locations; Geography; Growth; Health; Hospitals; Human; Immunohistochemistry; Informatics; Institutional Review Boards; International; Journals; Knowledge; Laboratories; Lead; Liquid substance; Malignant - descriptor; Malignant Neoplasms; Medical; Medical Research; Medical center; Methods; Microscopy; Molecular; National Cancer Institute; New York; Ohio; Participant; Pathologist; Pathology; Pathology Report; Patients; Pennsylvania; Performance; Population; Privacy; Protocols documentation; Quality Control; Race; Reporting; Research; Research Personnel; Resources; Science; Scientific Advances and Accomplishments; Services; Shipping; Ships; Site; Testing; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Tumor Tissue; Universities; University Hospitals; biobank; bioinformatics infrastructure; cancer care; cancer therapy; common rule; digital; experience; human tissue; improved; innovation; interest; meetings; novel; personalized medicine; preservation; programs; recruit; research study; sample collection; translational cancer research; translational scientist

PROJECT SUMMARY/ABSTRACT This proposal organizes the resources and experience of the Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) for participation as an Adult Division of the NCI Cooperative Human Tissue Network (CHTN). Our AGL-RBR group of pathologists is equipped to efficiently provide remnant patient consented biospecimens for basic and early translational cancer research as well as for biomarker research studies to support personalized medicine. The Ohio State University (OSU) Hospital and James Cancer Hospital in Columbus, OH will function as the Coordinating/Procurement Center while University Hospitals Cleveland Medical Center, Cleveland, OH, University at Buffalo hospital affiliations, Buffalo, NY and University of Pittsburgh Medical Center Shadyside, Pittsburgh, PA and associated hospitals will function as geographically distributed Procurement/Biorepository sites. The OSU Coordinating Center- Investigator Management Service will manage the investigator applications and approvals and investigator biospecimen request networking. The OSU Biospecimen Management Service will handle the tissue Quality Control, biospecimen storage and shipping and CHTN fee billing, collections and monthly accounting. Tissue Procurement supports custom biospecimen collection including investigator provided novel preservation fluids or methods. Available informatics support collection of data related to donor consents, biospecimens, investigators and billing. Shipped biospecimens include a redacted Pathology and QC Report for each biospecimen shipped. Pathology Reports at OSU for freshly procured tissues include clinically appropriate molecular testing. Investigators may also request, if IRB approved, extensive clinical data available from the OSU Information Warehouse (IW) and additional laboratory testing such as immunohistochemistry, tissue microarray construction, digital microscopy or digital morphometrics. Biospecimen donor privacy and confidentiality are essential elements of the AGL-RBR biospecimen management proposal so that all procured biospecimens are patient consented and coded. Delinking is available for special tissues that were not consented at procurement. The OSU procurement program joined the OSU Comprehensive Cancer Center (OSUCCC) in deploying the Total Cancer Care® (TCC) protocol in 2016 to provide comprehensive donor consent. Donors who consent give full use for future research all of their past, present and future remnant biomaterials to IRB approved researchers. Procurement/Biorepository sites have similar consent programs in place. Scientific or technical knowledge or discoveries acquired in the conduct of our tissue procurement/preservation program will be reported at national and international scientific and technical meetings to contribute to the growth of biospecimen science, to recruit new investigators who have research interests best served by human biospecimen research and to inform the research community and public.

项目概要/摘要 该提案整理了阿巴拉契亚和五大湖研究的资源和经验 生物样本资源 (AGL-RBR)，作为 NCI 合作人体组织的成人部门参与 网络 (CHTN)。我们的 AGL-RBR 病理学家小组能够有效地提供剩余患者。 用于基础和早期转化癌症研究以及生物标志物研究的同意生物样本 支持个性化医疗的研究。俄亥俄州立大学 (OSU) 医院和詹姆斯癌症中心。 俄亥俄州哥伦布市的医院将充当协调/采购中心，而大学医院将充当协调/采购中心 克利夫兰医学中心，克利夫兰，俄亥俄州，布法罗大学医院附属机构，纽约州布法罗和大学 宾夕法尼亚州匹兹堡谢迪赛德匹兹堡医疗中心和相关医院将作为 地理上分布的采购/生物储存库站点。 OSU 协调中心 - 调查员。 管理服务将管理研究者的申请和批准以及研究者的生物样本 OSU 生物样本管理服务将处理组织质量控制， 生物样本储存和运输以及 CHTN 费用计费、收集和每月会计。 采购支持定制生物样本采集，包括研究人员提供的新型保存液 可用的信息学支持收集与捐赠者同意、生物样本相关的数据， 运送的生物样本包括每个样本的经过编辑的病理学和质量控制报告。 俄勒冈州立大学新鲜采购的组织的病理学报告包括临床适用的。 如果 IRB 批准，研究人员还可以要求提供广泛的临床数据。 OSU 信息仓库 (IW) 和其他实验室测试，例如免疫组织化学、组织 微阵列构建、数字显微镜或数字形态测定学。 保密性是 AGL-RBR 生物样本管理提案的基本要素，以便所有采购的生物样本 生物样本经过患者同意并进行编码，对于未经患者同意的特殊组织可进行脱链。 采购时同意 OSU 采购计划加入 OSU 综合癌症中心。 (OSUCCC) 于 2016 年部署 Total Cancer Care® (TCC) 方案，以提供全面的捐赠者 同意的捐赠者将其过去、现在和未来的所有剩余物充分用于未来的研究。 IRB 批准的研究人员的生物材料采购/生物储存库也有类似的同意计划。 在我们组织的活动中获得的科学或技术知识或发现。 采购/保存计划将在国家和国际科学技术会议上报告 会议以促进生物样本科学的发展，招募有研究成果的新研究人员 人类生物样本最佳研究所服务的利益，并告知研究界和公众。