Systems Serology Core
系统血清学核心
基本信息
- 批准号:10616544
- 负责人:
- 金额:$ 29.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-12 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAntibodiesAntibody ResponseAreaAutologousBenchmarkingBiological AssayBiophysicsBirthCellsCollectionDataDevelopmentDimensionsEnsureEnvironmentFingerprintGenerationsGlycoengineeringGoalsHumanHuman ResourcesHumoral ImmunitiesImmuneImmune responseImmune systemImmunityImmunologicsInfantInfant HealthInfectionInfrastructureInterventionInvestigationKnowledgeLaboratoriesLeadershipLifeMaternal antibodyMaternally-Acquired ImmunityMonitorNatureNeonatalNewborn InfantPregnancyProtocols documentationQualifyingReagentResearchResourcesRoleRunningSamplingSerologyStandardizationSystemTechnical ExpertiseTechnologyTherapeuticTrainingVaccinationVaccinesWorkantibody testconditioninghigh standardimprovedin uterolaboratory experiencematernal vaccinationneonatal immunityneonatenew technologynext generationnovelprogramsresponsesuccesssynergismtechnology platformtool
项目摘要
CORE 1 – SYSTEMS SEROLOGY CORE – ABSTRACT
Accumulating data points to dramatic immunologic changes during pregnancy and early life. However, how these
immune perturbations alter the immune response to vaccination or to infection have yet to be fully defined. Under
Core 1, in depth comprehensive characterization will be performed on the humoral immune response to improve
our understanding of the mechanisms by which the immune system changes throughout pregnancy, how these
changes affect responses to vaccines and how infants benefit from maternal immunity and in turn respond to
vaccines. Specifically, Core 1 will exploit and evolve Systems Serology to broadly and deeply probe the nature
of the humoral immune response in a sample sparing manner, via the development of multiplexed-antibody
profiling approaches. Additionally Core 1 will develop lower-throughput functional assays to probe the interaction
between antibodies and host-innate immune cells, in a fully autologous fashion, to define the overall impact of
altered antibody and cellular state in pregnancy and early life. Thus Core 1 will deeply interrogate and define
changes in humoral immunity throughout pregnancy, at birth, and throughout early infant life. The Core leader
will provide all the expertise, infrastructure, reagents, personnel, and training, to ensure the efficient and
successful analysis and deployment of this technology under Projects 1 & 2, as well as support in generating
data for Projects 2 & 4. Thus the main role of this Core is to provide the leadership and the technical expertise
to ensure that antibody assays are run in a standard fashion, that novel technologies evolve from this Core to
support the needs of the overall Consortium, and that the Consortium is kept abreast of the latest developments
in assessing antibody responses.
核心1 - 系统血清学核心 - 摘要
在怀孕和早期生命期间累积数据点,以引起急剧的免疫学变化。但是,这些是如何的
免疫扰动改变了对疫苗接种或感染的免疫反应,尚未完全定义。在下面
核心1,将在体验免疫响应上进行深入的全面表征以改进
我们对免疫系统在整个怀孕期间发生变化的机制的理解,这些机制如何
变化会影响对疫苗的反应以及婴儿如何从母子免疫中受益,然后对
疫苗。具体而言,核心1将利用和进化系统的血清学来广泛,深入探测性质
通过样品产卵方式的体液免疫反应,通过多重抗体的发展
分析方法。此外,Core 1将开发低通量功能测定法以探测相互作用
以完全自体的方式在抗体和宿主融合免疫细胞之间,以定义
在怀孕和早期生命中改变抗体和细胞状态。该核心1将深入询问和定义
整个怀孕,出生和整个婴儿早期生活的体液免疫学的变化。核心负责人
将提供所有专业知识,基础设施,试剂,人员和培训,以确保高效和
在项目1和2下,成功分析和部署了这项技术,并支持生成
项目2和4的数据。该核心的主要作用是提供领导和技术专长
为了确保以标准方式运行抗体测定,这种新技术从该核心发展到
支持整个财团的需求,并且该财团与最新发展保持一致
在评估抗体反应时。
项目成果
期刊论文数量(0)
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{{ truncateString('Galit Alter', 18)}}的其他基金
Defining humoral correlates of immunity against COVID-19
定义 COVID-19 免疫力的体液相关性
- 批准号:
10265799 - 财政年份:2020
- 资助金额:
$ 29.45万 - 项目类别:
Immunologic Signatures of SARS-CoV-2 Vaccination and Disease
SARS-CoV-2 疫苗接种和疾病的免疫学特征
- 批准号:
10221341 - 财政年份:2020
- 资助金额:
$ 29.45万 - 项目类别:
Multiplexed Antigen-Specific Antibody Fc Profiling on a Chip for Point-of-Care Diagnosis of TB in HIV-infected Children
芯片上的多重抗原特异性抗体 Fc 分析用于 HIV 感染儿童结核病的护理点诊断
- 批准号:
10159844 - 财政年份:2020
- 资助金额:
$ 29.45万 - 项目类别:
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