Core B

核心B

基本信息

批准号：
10339364
负责人：
Galit Alter
金额：
$ 99.39万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10339364
关键词：
Antibodies Antibody Response Binding Biological Assay Biometry Cell physiology Cells Clinical Complement Data Development Ensure Epitopes Fc Receptor Goals HIV vaccine Human Human Resources Humoral Immunities Immune Immune response Immunity Immunologic Monitoring Immunologics Immunology Infection Infection prevention Infrastructure Institutes Israel Leadership Lectin Link Macaca mulatta Measurement Mediating Medical center Mission Neutralizing antibody assay Positioning Attribute Process Proteins Reagent Regimen Research Personnel Role SIV Sampling Studies Serology Serum Services Standardization Statistical Data Interpretation System Technical Expertise Vaccination Vaccines Virus Diseases Work neutralizing antibody nonhuman primate pathogen prevent programs recruit response simian human immunodeficiency virus vaccine-induced immunity

项目摘要

Core B (Immunology Core) will provide standardized humoral immune monitoring assay services for evaluating antibody responses elicited by Ad26-Env/Gag/Pol prime, Env gp140 protein boost (Ad26/Env) vaccine regimens in the studies described in this IPCAVD program. Core B leadership will work closely with investigators responsible for the studies described in Project 1 and Project 2 and will participate actively in the scientific mission of the overall IPCAVD program. The primary goal of Core B is to provide the leadership and the technical expertise to ensure that all vaccine-induced humoral responses will be profiled in a standardized fashion and that the IPCAVD leadership is kept abreast of the latest developments in assessing vaccine-induced neutralizing and non-neutralizing humoral immunity, particularly in relation to their ability to prevent viral infection. To accomplish these goals, we propose the following three Specific Aims: Specific Aim 1. To perform standardized neutralizing antibody (NAb) assays in both NHP and humans Specific Aim 2. To perform standardized non-neutralizing antibody assays in both NHP and humans Specific Aim 3. To integrate all antibody data into a Systems Serology profiling approach to define correlates of protective immunity

核心B（免疫学核心）将为以下人群提供标准化的体液免疫监测检测服务：评估 Ad26-Env/Gag/Pol prime、Env gp140 蛋白增强 (Ad26/Env) 引发的抗体反应本 IPCVD 计划中描述的研究中的疫苗方案。核心B领导层将密切合作与负责项目 1 和项目 2 中描述的研究的研究人员一起，并将积极参与整个 IPCVD 计划的科学使命。核心 B 的主要目标是提供领导力以及技术专业知识，以确保所有疫苗引起的体液反应都将在一个标准化时尚，并且 IPAVD 领导层随时了解评估的最新发展疫苗诱导的中和和非中和体液免疫，特别是与它们的能力有关预防病毒感染。为了实现这些目标，我们提出以下三个具体目标：具体目标 1. 在 NHP 和人类中进行标准化中和抗体 (NAb) 测定具体目标 2. 在 NHP 和人类中进行标准化非中和抗体测定具体目标 3. 将所有抗体数据整合到系统血清学分析方法中以定义相关性具有保护性免疫力