Admin Core

管理核心

• 批准号: 10613374
• 负责人: Serdar E. Bulun
• 金额: $ 10.09万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10613374
• 关键词: 3-Dimensional; Acceleration; Administrator; Advisory Committees; Affect; African American; Age Years; Area; Biology; Caucasians; Cell Culture Techniques; Cells; Chromatin; Communication; Development; Education and Outreach; Ensure; Epigenetic Process; Feedback; Fibroid Tumor; Financial Support; Fostering; Funding; Future; Genotype; Goals; Growth; Gynecologic; HMGA2 gene; Health; Human Resources; Individual; Knowledge; Link; Medical; Methodology; Mission; Mutation; National Institute of Child Health and Human Development; Pathologist; Pilot Projects; Population; Process; Progesterone; Recurrence; Research; Research Personnel; Research Project Grants; Resources; Running; Science; Series; Services; Somatic Mutation; Structure; Symptoms; Tissue Banks; Tissue Procurements; Tissue Sample; Tissues; Training Activity; Tumor Biology; United States National Institutes of Health; Update; Uterine Fibroids; Uterus; Woman; Work; base; cell preparation; community based participatory research; community engagement; design; epigenomics; experience; genome-wide; high throughput technology; human tissue; in vivo Model; insight; meetings; novel; precision medicine; prevent; procedure cost; response; side effect; stem cell function; synergism; therapeutic target; tumor; tumorigenesis

The overall goal of the Administrative Core is to provide a robust centralized administrative structure that will coordinate the activities of the proposed NCTRI Northwestern Uterine Leiomyoma Center researchers and provide operational support that will reduce the burden on its investigators, allowing them to focus on their research. The Core will ensure that the proposed Center achieves its aims and will synergize the efforts of the Research Project investigators with the work of the Education and Outreach Core and the Tissue Procurement and Cell Culture Core. The Administrative Core will coordinate the participation of the Research Project investigators in the community engagement and research training activities of the Education and Outreach Core. We have developed an optimally organized Tissue/Cell Core, run by an experienced gynecologic pathologist to support LM research at Northwestern; this will provide an efficient facility for procuring and banking tissue samples and for cell preparation and storage. This facility is entirely supported by intramural funds from Northwestern. The Administrative Core will ensure and coordinate the distribution of human tissues and cells to all Center investigators. The Core will also solicit and coordinate a rigorous review process for Pilot Project applications. Below are the aims of the Administrative Core, which capture the overall objectives. AIM 1. Reduce administrative barriers within and between Center Research Projects by providing funds and resource management services. AIM 2. Foster team science through established communication methodologies to integrate cross-disciplinary research and coordinate scientific efforts within the Center and externally. AIM 3. Provide an administrative framework to evaluate the progress of the Research Projects and the Cores to ensure a rapid pace of high-quality research and to solicit Pilot Project applications and rigorously select the best Pilot Project. All aims will be achieved through the efforts of the Core Director, Dr. Bulun and the Research Administrator, Erin Simpson, who will provide overall and comprehensive administrative support. Aim 1 is designed to provide support for financial and human resources management for the investigators, projects and cores; the Bulun and Simpson team will serve as the liaison to NIH and to central offices at Northwestern. Aim 2 will be accomplished through a series of communication efforts, including recurring meetings for research progress and communication updates and the coordination of the Research Projects and Core functions. Aim 3 will support the efforts of the Internal and External Advisory Committees that will review each project's progress and provide feedback on the overall Center and help review the Pilot Project applications and select the best Pilot Project. By aligning the Center through these activities, the Administrative Core will ensure the uninhibited progress of the Center's research, leverage team science and cross-disciplinary efforts to accelerate the pace of discovery, and evaluate progress and trajectory so the Center is consistently on target.

行政核心的总体目标是提供一个强大的集中管理结构， 协调拟建的 NCTRI 西北子宫平滑肌瘤中心研究人员的活动，以及 提供业务支持，减轻调查人员的负担，使他们能够专注于自己的工作 研究。核心将确保拟议的中心实现其目标，并将协同各方的努力 研究项目调查员负责教育和外展核心以及组织采购工作 和细胞培养核心。行政核心将协调研究项目的参与 教育和外展核心的社区参与和研究培训活动的调查员。 我们开发了一个组织/细胞核心的最佳组织，由经验丰富的妇科病理学家运行，以 支持西北大学的改性活研究；这将为采购和储存组织提供有效的便利 样品以及细胞制备和储存。该设施完全由来自以下机构的校内资金支持 西北。行政核心将确保和协调人体组织和细胞的分配 所有中心调查员。核心还将征求并协调试点项目的严格审查流程 应用程序。以下是行政核心的目标，其中体现了总体目标。目标 1. 减少 通过提供资金和资源消除中心研究项目内部和之间的行政障碍 管理服务。目标 2. 通过既定的沟通方法培养团队科学 整合跨学科研究并协调中心内外的科学工作。目标3。 提供一个管理框架来评估研究项目和核心的进展，以确保 快速开展高质量研究，征集试点项目申请并严格选择最佳试点 项目。所有的目标都将通过核心主任Bulun博士和研究室的努力来实现 管理员艾琳·辛普森 (Erin Simpson) 将提供全面的行政支持。目标 1 是 旨在为研究者、项目和人员提供财务和人力资源管理支持 核心； Bulun 和 Simpson 团队将充当 NIH 和西北大学中央办公室的联络人。目的 2 将通过一系列沟通工作来完成，包括定期举行的研究会议 研究项目和核心职能的进展和沟通更新以及协调。目标 3 将支持内部和外部咨询委员会的工作，该委员会将审查每个项目的进展 提供对整个中心的反馈，帮助审查试点项目申请并选择最佳的 试点项目。通过这些活动使中心保持一致，行政核心将确保不受约束 中心研究进展，利用团队科学和跨学科努力加快步伐 发现，并评估进展和轨迹，以便中心始终如一地实现目标。