Patient-Directed Computational Analysis of Atrial Fibrillation

患者导向的心房颤动计算分析

基本信息

批准号：
10610778
负责人：
WOUTER-JAN RAPPEL
金额：
$ 57.12万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-01-12 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10610778
关键词：
3-Dimensional Ablation Acute Affect Algorithms American Arrhythmia Atrial Fibrillation Automobile Driving Blinded Caring Characteristics Chronic Clinical Clinical Trials Complex Computational Technique Computer Analysis Computer Models Computer Simulation Data Development Digital Computers Electrophysiology (science)Extinction Freedom Frequencies Funding Geometry Goals Health Heart Atrium Heart failure Hour Left Maintenance Maps Mediating Meta-Analysis Modeling Morbidity - disease rate Observational Study Outcome Patients Pattern Persons Pharmacotherapy Phase Physics Procedures Public Health Pulmonary veins Registries Reporting Source Stroke Techniques Testing Therapeutic Time Tissues Translating Work effective therapy improved indexing individual patient interest mortality novel novel therapeutics open source patient registry prospective test randomized trial simulation source localization spatiotemporal success therapy development

项目摘要

Patient-Directed Computational Analysis of Atrial Fibrillation Project Summary Atrial fibrillation (AF) is the most common arrhythmia and is a rapidly-growing public health problem that currently affects over 30 million people world-wide and more than 5 million people in the US. If left untreated, AF leads to an increase in stroke, heart failure and mortality. Unfortunately, the mechanisms that maintain AF remain poorly understood, hindering further improvement of current therapy strategies. Recent studies, however, have revealed that AF may be driven by rotational or focal sources and that targeting these sources using localized ablation can result in promising long-term outcomes. Due to our incomplete understanding of AF, however, this targeted ablation approach is not always successful. This project will test the novel hypothesis that AF is sustained by localized rotational and focal sources with different size and temporal stability and that, after these sources are removed, termination is not immediate but is maintained by non-local mechanisms. We will address this hypothesis using a combined computational/clinical approach that employs advanced multiscale computational techniques and state-of-the-art clinical mapping. The project will 1) quantify AF organization using patient-specific geometries; 2) determine whether some rotational or focal sources are more important than others; 3) test possible causes of AF maintenance and termination using patient-specific digital computer models. We will use data from our unique and large patient registry, currently totaling >500 patients. This project is significant because it will establish a deeper understanding of AF and might reveal novel mechanisms of AF maintenance. Our results can be translated directly to practice and may enable the development of better treatment options.

房颤的患者指导计算分析项目摘要心房颤动（AF）是最常见的心律不齐，是一种快速增长目前在全球影响超过3000万人的公共卫生问题在美国有超过500万人。如果未经治疗，AF会导致中风，心力衰竭和死亡率的增加。不幸的是，机制维持AF仍然很了解，阻碍了当前的进一步改善治疗策略。然而，最近的研究表明AF可能是由旋转或焦点来源驱动，并使用局部消融可能会导致有希望的长期结局。由于我们然而，对AF的不完全了解，这种目标消融方法不是总是成功。该项目将检验新的假设，即AF由本地化维持具有不同大小和时间稳定性的旋转和焦点源，删除这些来源后，终止不是立即的，而是维持的通过非本地机制。我们将使用合并的采用高级多尺度计算的计算/临床方法技术和最先进的临床映射。该项目将1）量化AF 使用特定于患者的几何形状的组织； 2）确定是否有些旋转或焦点比其他人更重要。 3）可能的测试使用特定于患者的数字计算机使用AF维护和终止的原因型号。我们将使用目前的独特和大型患者注册表中的数据总计> 500名患者。该项目很重要，因为它将对AF建立更深入的了解并可能揭示了AF维护的新型机制。我们的结果可能是直接翻译成实践，并可以使发展的发展治疗选择。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

High-order finite element methods for cardiac monodomain simulations.

DOI：
10.3389/fphys.2015.00217
发表时间：
2015
期刊：
Frontiers in physiology
影响因子：
4
作者：
Vincent KP;Gonzales MJ;Gillette AK;Villongco CT;Pezzuto S;Omens JH;Holst MJ;McCulloch AD
通讯作者：
McCulloch AD

To the Editor- On the deformation and interpolation of phase maps.

致编辑 - 关于相位图的变形和插值。