Training Program in Translational Science, HIV, and Sexual and Gender Minority Health

转化科学、艾滋病毒、性和性别少数群体健康培训计划

• 批准号: 10608209
• 负责人: Michael E Newcomb
• 金额: $ 51.93万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608209
• 关键词: HIV; Sexual and Gender Minorities; Training Programs; Translational Research; gender minority health

Project Summary Sexual and gender minorities (SGM) are heavily burdened by HIV in the U.S., including cisgender sexual minority men, transgender women and men, and non-binary people assigned male at birth. SGM also experience vast health inequities outside of HIV, including mental health problems, substance use, and various physical health outcomes. Minority stressors (i.e., those unique to SGM) are linked to HIV-related outcomes and mental health, driven by various biopsychosocial processes. Further, these health issues do not occur in a vacuum; multiple, comorbid health-related issues interact synergistically to form a “syndemic” that drives HIV incidence and HIV care outcomes among SGM. In order to rapidly address these issues, we need skilled translational scientists who can delineate the mechanistic processes driving disparities, translate findings into interventions, and implement programs with communities. Built on the infrastructure of Northwestern's Institute for Sexual and Gender Minority Health and Wellbeing, the TrainingProgram in Translational Science, HIV, andSexual and Gender Minority Health (NU-THRIVE)will support promising scientists in building the skills necessary to understand these complex relationships and mitigate health disparities impacting SGM people, including HIV. NU-THRIVE aims to train postdoctoral fellows in research methods across the Translational Science Spectrum through a rigorous program in which they will: 1) specialize and gain depth of knowledge in 2 Translational Science Skill Domains (i.e., Quantitative Methods, Qualitative Methods, Interventions & Trials, Implementation Science) through mentored research; and 2) gain breadth of knowledge in all 4 domains through a formal training curriculum. NU-THRIVE will support 3 new postdoctoral fellows per year, on 2-year appointments. We expect a majority will have a PhD (behavioral/social science) and a minority will be MD physician-scientists. Fellows will select 1 Primary and 1 Secondary Mentor. Primary Mentors are faculty who focus primarily on HIV, mental health, and/or SGM health. Secondary Mentors come from a range of disciplines and have expertise complementary to the aims of NU-THRIVE but may work outside of or adjacent to HIV and mental health among SGM. Fellows will gain knowledge and skills in 8 core competencies: 1) translational science in HIV & SGM health; 2) biopsychosocial drivers of HIV, mental health, & associated comorbidities; 3) developmental lifespan & environmental influences on HIV, mental health, & comorbidities; 4) intersectional identities, HIV, & SGM health; 5) team science skills; 6) ethics & responsible conduct of research; 7) writing, dissemination, & grantsmanship; 8) professional & career development. NU-THRIVE training modalities will include mentored research activities, a didactic seminar series, intensive trainings in translational science methods, structured writing support, and other activities available in the rich Northwestern environment. NU-THRIVE will place fellows at the forefront of HIV and SGM health research, with the goal of more rapidly moving basic science discoveries to efficacious interventions and onward toward implementation.

项目摘要 性别和性别少数群体（SGM）在美国的艾滋病毒中被大量燃烧 少数族裔男性，跨性别男女，以及非二进制男人出生时分配男性。也是SGM 在艾滋病毒之外遇到巨大的健康不平等，包括心理健康问题，药物使用和各种 身体健康结果。少数压力源（即SGM独有的压力源）与与HIV相关的结果有关 以及由各种生物心理社会过程驱动的心理健康。此外，这些健康问题不会发生在 真空;多个合并症与健康相关的问题协同互动，形成了促使艾滋病毒的“辛迪姆” SGM之间的发病率和艾滋病毒护理结果。为了快速解决这些问题，我们需要熟练 可以描绘机械过程的转化科学家，将发现转化为 干预措施和社区实施计划。建立在西北研究所的基础设施上 对于性和性别少数民族健康和福祉，艾滋病毒的训练计划，艾滋病毒， 以及性别和性别少数族裔健康（NU-Thrive）将支持有前途的科学家建立技能 了解这些复杂的关系并减轻影响SGM人的健康差异所必需的， 包括艾滋病毒。 NU-Thrive的目的是在翻译的研究方法中训练博士后研究员 通过严格的计划，科学范围：1）专业并获得知识深度 2转化科学技能领域（即定量方法，定性方法，干预和试验， 实施科学）通过指导的研究； 2）在所有四个领域中获得知识广度 通过正式的培训课程。 NU-Thrive将在2年内支持3个新的博士后研究员 约会。我们预计大多数将拥有博士学位（行为/社会科学），少数将是MD 医师科学家。研究员将选择1位初级和1个次要导师。主要导师是教师 将主要关注艾滋病毒，心理健康和/或SGM健康。次要导师来自一系列 学科并具有专业知识的完整性，以努力的目的，但可能在外面或相邻工作 SGM中的艾滋病毒和心理健康。研究员将在8个核心能力中获得知识和技能：1） HIV和SGM Health的转化科学； 2）艾滋病毒，心理健康和相关的生物心理社会驱动因素 合并症； 3）发展寿命和环境对艾滋病毒，心理健康和合并症的影响； 4） 交叉身份，HIV和SGM Health； 5）团队科学技能； 6）道德和负责任的行为 研究; 7）写作，传播和授予技巧； 8）专业和职业发展。努力 培训方式将包括修改研究活动，教学半手系列，密集培训 翻译科学方法，结构化写作支持以及其他西北地区可用的活动 环境。 Nu-Thrive将把研究员放在艾滋病毒和SGM健康研究的最前沿，目的是 更快地将基础科学发现到有效的干预措施，并继续进行实施。