RADIOIMMUNOTHERAPY AND EXTRACORPOREAL ADSORPTION THERAPY STUDIES IN MACAQUES

猕猴的放射免疫治疗和体外吸附治疗研究

• 批准号: 7958871
• 负责人: Oliver W. Press
• 金额: $ 15.76万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958871
• 关键词: Acute leukemia; Adsorption; Antibodies; Biodistribution; Cells; Computer Retrieval of Information on Scientific Projects Database; Dose; Drug Kinetics; Funding; Goals; Grant; Institution; Low Dose Radiation; Macaca; Methods; Monoclonal Antibodies; Non-Hodgkin' s Lymphoma; Organ; Outcome; Patients; Primates; Radiation; Radioactivity; Radioimmunotherapy; Radiolabeled; Research; Research Personnel; Resources; Safety; Source; Stem cell transplant; Tissues; Toxic effect; United States National Institutes of Health; improved; leukemia/lymphoma; nonhuman primate; radiotracer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to improve the outcome of stem cell transplantation for patients with non-Hodgkin's lymphoma and acute leukemia by delivering supplemental radiation to target lymphohematopoietic tissues using radiolabeled monoclonal antibodies (radioimmunotherapy, RIT). The improvement of targeting methods may allow the delivery of larger doses of radioactivity from antibody to leukemia and lymphoma cells, while delivering lower radiation doses to normal organs, resulting in higher cure rates and less treatment-related toxicity. The specific aims in these non-human primate studies are: a. To evaluate the feasibility, safety, and toxicity of administering radiolabeled-biotinylated antibodies followed by extracorporeal adsorption in macaques. b. To assess the impact of extracorporeal adsorption therapy (ECAT) on the pharmacokinetics and biodistribution of radiolabeled-biotinylated antibodies in macaques.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的总体目标是通过使用放射性标记的单克隆抗体（放射免疫疗法，RIT）向目标淋巴造血组织提供补充放射，改善非霍奇金淋巴瘤和急性白血病患者干细胞移植的结果。靶向方法的改进可能允许从抗体向白血病和淋巴瘤细胞传递更大剂量的放射性，同时向正常器官传递更低的辐射剂量，从而导致更高的治愈率和更少的治疗相关毒性。这些非人类灵长类动物研究的具体目标是： 一个。 评估在猕猴体内施用放射性标记生物素化抗体并随后进行体外吸附的可行性、安全性和毒性。 b. 评估体外吸附疗法 (ECAT) 对猕猴体内放射性标记生物素化抗体的药代动力学和生物分布的影响。