Integrated Health Sciences Facility Core

综合健康科学设施核心

基本信息

批准号：
10610092
负责人：
Manish Arora
金额：
$ 32.96万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-18 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10610092
关键词：
Acceleration Address Adolescence Adopted Air Pollution Analytical Chemistry Big Data Biological Biological Assay Biological Markers Center for Translational Science Activities Chemicals Chronic Disease Clinic Clinical Clinical Medicine Clinical Research Clinical and Translational Science Awards Collaborations Communities Complex Consultations Core Facility Counseling DNA Sequencing Facility Data Disease Progression Dose Educational workshop Elderly Ensure Environment Environmental Exposure Environmental Health Environmental Risk Factor Epidemiology Epigenetic Process Exposure to Faculty Recruitment Financial Support Fostering Funding Goals Grant Growth Hair Health Health Sciences Health system Human Human Development Individual Institution International Laboratories Lead Life Life Cycle Stages Link Longevity Measures Methods Mission Mitochondria Modeling National Institute of Environmental Health Sciences Patients Phenotype Pilot Projects Play Population Predisposition Pregnancy Progress Reports Publications Research Research Design Research Personnel Resolution Resources Role Science Scientist Services Technology Temperature Sense Testing Tooth structure Toxic Environmental Substances Toxicology Translational Research Translations United States National Institutes of Health Update Weather Work base biobank biological specimen archives cohort community engagement critical period design early childhood environmental justice equity, diversity, and inclusion health inequalities health science research infancy innovation insight member middle age molecular marker new technology novel patient response programs remote sensing research study response response biomarker study population success treatment response ward

Acceleration Address Adolescence Adopted Air Pollution Analytical Chemistry Big Data Biological Biological Assay Biological Markers Center for Translational Science Activities Chemicals Chronic Disease Clinic Clinical Clinical Medicine Clinical Research Clinical and Translational Science Awards Collaborations Communities Complex Consultations Core Facility Counseling DNA Sequencing Facility Data Disease Progression Dose Educational workshop Elderly Ensure Environment Environmental Exposure Environmental Health Environmental Risk Factor Epidemiology Epigenetic Process Exposure to Faculty Recruitment Financial Support Fostering Funding Goals Grant Growth Hair Health Health Sciences Health system Human Human Development Individual Institution International Laboratories Lead Life Life Cycle Stages Link Longevity Measures Methods Mission Mitochondria Modeling National Institute of Environmental Health Sciences Patients Phenotype Pilot Projects Play Population Predisposition Pregnancy Progress Reports Publications Research Research Design Research Personnel Resolution Resources Role Science Scientist Services Technology Temperature Sense Testing Tooth structure Toxic Environmental Substances Toxicology Translational Research Translations United States National Institutes of Health Update Weather Work base biobank biological specimen archives cohort community engagement critical period design early childhood environmental justice equity, diversity, and inclusion health inequalities health science research infancy innovation insight member middle age molecular marker new technology novel patient response programs remote sensing research study response response biomarker study population success treatment response ward

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项目摘要

Project Summary (IHSFC) The mission of the Mount Sinai Center on Health and Environment Across the LifeSpan (HEALS) is to promote team-based environmental health science (EHS) research that embraces a life course approach to EHS. Within the Center, the Integrated Health Sciences Facility Core (IHSFC), serves as a key linchpin in the Center's activities, providing researchers with expert consultation on exposure science, toxicology, life course human development, biomarkers of exposure and biological response, lab feasibility assessment and access to clinical and epidemiologic population resources. The IHSFC promotes research translation with the Community Engagement Core(CEC) and connects Center Members with additional Mount Sinai Core resources, such as those found in our Clinical Translational Science Award (CTSA). This work is facilitated in part through our very close CTSA relationship, as Dr Rosalind Wright, Center Deputy Director and Phenotyping and Effect Modifier Facility Core (PEMFC) leader is also the CTSA director. Dr Maida Galvez, our CEC Leader, also leads Community Engagement in the CTSA giving us substantial access to, and expertise in, clinical and translational research resources. Working with Center Members we adapt our expertise and resources to fit measures that are ideal for different life stages with a focus on particular critical periods (pregnancy, infancy, early childhood, adolescence, midlife, elderly) during which individuals are commonly more susceptible to environmental exposures. Exposure assessment offerings include targeted and untargeted exposure assays, tooth based biomarkers that reconstruct early life environment, and satellite based remote sensing “big data” models that assess air pollution and weather among other variables. The IHSFC also fosters studies that emphasize environmental justice, as well as environmental clinical research (i.e. the role of environmental factors on patient response to treatment and/or disease progression). We help Center investigators establish teams of cross-disciplinary collaborators who together will extend the boundaries of environmental health sciences. The IHSFC has developed innovative methods to comprehensively measure past exposure to environment insults and facilitated access to clinical populations and biospecimen archives that have led to new R01 grants in EHS. The IHSFC does not replicate services provided by other Mount Sinai core labs, such as those supported by our CTSA. Rather, the IHSFC leverages and supplements CTSA resources to facilitate Center Member access to additional relevant core labs (e.g. CTSA sequencing core) as well as the Mount Sinai institutional biobank (BioME). The IHSFC is a resource that allows researchers to build highly efficient and collaborative teams that conduct research that positively impacts health across the lifespan. In sum, the IHSFC serves as a gateway to a variety of expertise and resources under a single administrative umbrella, providing an intellectual milieu that promotes collaboration and brings EHS to research programs across the Mount Sinai Health System.

项目摘要（IHSFC）西奈山中心在整个生命周期（治愈）的健康与环境中心的任务是促进基于团队的环境健康科学（EHS）研究，该研究采用了生活课程的方法 EHS。在中心内，综合健康科学设施核心（IHSFC）是关键的关键该中心的活动，为研究人员提供有关暴露科学，毒理学，生活的专家咨询课程人类发展，暴露和生物反应的生物标志物，实验室可行性评估和获取临床和流行病学人群资源。 IHSFC通过社区参与核心（CEC），并将中心成员与Sinai Mount Mount Core相连资源，例如我们的临床转化科学奖（CTSA）中发现的资源。这项工作是准备通过我们非常紧密的CTSA关系，作为中心副董事兼表型Rosalind Wright博士和效果修饰设施核心（PEMFC）领导者也是CTSA主管。我们的CEC负责人Maida Galvez博士，还领导社区参与CTSA，使我们获得了临床和专业知识的大量访问和专业知识翻译研究资源。与中心成员合作，我们调整我们的专业知识和资源以适合非常适合不同生活阶段的措施，重点是特定的关键时期（怀孕，婴儿期，幼儿，青少年，中年，年龄较长），在此期间，个人通常更容易受到环境暴露。曝光评估优惠包括针对性和无目标的曝光测定法，基于牙齿的生物标志物，重建早期生活环境和基于卫星的遥感“大数据” 评估空气污染和天气以及其他变量的模型。 IHSFC还促进了研究强调环境正义以及环境临床研究（即环境的作用患者对治疗和/或疾病进展的反应的因素）。我们帮助中心调查人员建立跨学科合作者的团队将共同扩大环境健康的边界科学。 IHSFC已经开发了创新的方法，可以全面衡量过去的接触环境侮辱并促进了导致临床人群和生物循环档案 EHS中的新R01赠款。 IHSFC不复制其他西奈山核心实验室提供的服务，例如正如我们的CTSA支持的那些。相反，IHSFC利用并补充了CTSA资源以促进中心成员访问其他相关核心实验室（例如CTSA测序核心）以及安装座西奈机构生物库（Biome）。 IHSFC是一种允许研究人员建立高效的资源以及进行研究的协作团队，从而对整个生命周期的健康产生积极影响。总而言之 IHSFC在单个行政伞下是通往各种专业知识和资源的门户，提供一个智力环境，该环境促进合作，并将EHS带入整个跨越的研究计划西奈山卫生系统。