Innovative Alcohol Intake Pattern Measurement for Human and Animal Model Research

用于人类和动物模型研究的创新酒精摄入模式测量

• 批准号: 8009272
• 负责人: Thomas K Greenfield
• 金额: $ 7.41万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009272
• 关键词: Acute; Address; Advisory Committees; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Animal Model; Basic Science; Biological; Biological Sciences; Blood alcohol level measurement; California; Clinical; Clinical Research; Collaborations; Communities; Country; Epidemiology; Etiology; Extramural Activities; Fertilization; Grant; Heart; Human; Institutes; Journals; Longevity; Measurement; Measures; Medical; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Patient Self-Report; Pattern; Physiological; Population; Prevention; Prevention Research; Public Health; Published Comment; Recommendation; Recording of previous events; Research; Research Priority; Sales; Science; System; Techniques; Time; Work; alcohol effect; alcohol exposure; alcohol research; alcohol use disorder; clinical epidemiology; falls; human population study; improved; innovation; innovative technologies; meetings; mortality; public health relevance; standardize measure; symposium

DESCRIPTION (provided by applicant): The National Alcohol Research Center (ARC) on the Epidemiology of Alcohol Problems at the Public Health Institute (PHI), Alcohol Research Group (ARG), Emeryville, CA (hereafter the Epidemiology Center or PHI Center), proposes to hold a Center Directors Meeting on the following topic: Innovative Alcohol Intake Pattern Measurement for Human and Animal Model Research on October 19 and 20, 2010 in Berkeley, California. This application for a R13 conference grant responds to PA-08-0149 and its theme is responsive to the first research priority recommendation made by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Extramural Advisory Committee, August 2006, intended to guide activities of the NIAAA Division of Epidemiology and Prevention: "Encourage systematic efforts to improve and standardize measures of patterns of alcohol exposure (acute, recent, or current history, and across the lifespan) and encourage their application across different grants, institutes, countries, and the medical system." A related recommendation focused on improving measurement of patterns of alcohol exposure to establish their effects on morbidity and mortality. While the PHI Epidemiology Center seeks to address these priorities in human and population studies, other Alcohol Research Centers focus on a wide range of topics involving biological, clinical, and community systems, including both human and animal model research. Recent advances have been made in self-report measurement of patterns of alcohol intake. Innovative technologies including physiological measures have been used to validate the new measures which have shown greater precision, coverage of national sales, and ability to predict alcohol dependence and acute harms. Similar advances are being made in measurement techniques in basic biomedical studies of alcohol effects. The meeting intends to bring together senior Alcohol Research Center leaders to examine and discuss the new work on alcohol consumption pattern measurement both in human population and clinical studies, and in animal model research that is at the heart of many of the advances in basic research on the etiology of alcohol use disorders (AUD). Our application at this time is prompted by an invitation from NIAAA to host the next Center Directors Meeting in the fall of 2010. The NIAAA has asked us to apply for the R13 Conference Grant for this purpose. The meeting would have a broad, multi- disciplinary viewpoint and engage the NIAAA and its Alcohol Research Centers in cutting-edge aspects of the topic we have selected. We plan to edit a special edition of a journal to collect the presentations at the meeting and bring them to a wider audience. PUBLIC HEALTH RELEVANCE: Relevance: It is timely to hold an interdisciplinary and translational meeting of senior Center leaders on alcohol pattern measurement that will cut across the fields of epidemiology, clinical and prevention research, and basic biological sciences relying on animal models. The cross fertilization and collaborations sparked will have the potential to accelerate the pace of science by sharing techniques of real-time ethanol intake measurement and indicators of blood alcohol level, crucial for better understanding alcohol-related morbidity and mortality.

描述（由申请人提供）： 加利福尼亚州埃默里维尔公共卫生研究所 (PHI) 酒精研究小组 (ARG) 酒精问题流行病学国家酒精研究中心 (ARC)（以下简称流行病学中心或 PHI 中心）提议召开一次中心主任会议主题如下：人类和动物模型研究的创新酒精摄入模式测量，2010 年 10 月 19 日至 20 日在加利福尼亚州伯克利举行。此 R13 会议拨款申请响应 PA-08-0149，其主题响应国家酒精滥用和酒精中毒研究所 (NIAAA) 校外咨询委员会 2006 年 8 月提出的第一项研究优先建议，旨在指导以下活动： NIAAA 流行病学和预防部门：“鼓励系统性地努力改进和标准化酒精暴露模式的测量（急性、近期或当前历史，以及整个生命周期），并鼓励其应用跨越不同的拨款、机构、国家和医疗系统。”一项相关建议侧重于改进对酒精暴露模式的测量，以确定其对发病率和死亡率的影响。虽然 PHI 流行病学中心致力于解决人类和人口研究中的这些优先事项，但其他酒精研究中心专注于涉及生物、临床和社区系统的广泛主题，包括人类和动物模型研究。最近在酒精摄入模式的自我报告测量方面取得了进展。包括生理测量在内的创新技术已被用来验证新测量方法，这些测量方法显示出更高的精确度、覆盖全国的销售范围以及预测酒精依赖和急性伤害的能力。酒精影响的基础生物医学研究的测量技术也取得了类似的进展。会议旨在聚集酒精研究中心的高级领导，研究和讨论在人群和临床研究以及动物模型研究中酒精消费模式测量的新工作，这是基础研究许多进展的核心。酒精使用障碍（AUD）的病因学。我们这次提出申请是因为 NIAAA 邀请我们在 2010 年秋季主办下一次中心主任会议。NIAAA 已要求我们为此目的申请 R13 会议拨款。会议将具有广泛的、多学科的观点，并让 NIAAA 及其酒精研究中心参与我们所选主题的前沿方面。我们计划编辑一本期刊特刊，收集会议上的演讲内容，并将其带给更广泛的受众。 公共卫生相关性： 相关性：现在是时候召开一次中心高级领导人关于酒精模式测量的跨学科和转化会议，该会议将跨越流行病学、临床和预防研究以及依赖动物模型的基础生物科学领域。所引发的交叉受精和合作将有可能通过共享实时乙醇摄入量测量技术和血液酒精水平指标来加快科学步伐，这对于更好地了解与酒精相关的发病率和死亡率至关重要。