Drinking Patterns & Ethnicity: Impact on Mortality Risks

饮酒模式

• 批准号: 7676820
• 负责人: Thomas K Greenfield
• 金额: $ 31.77万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676820
• 关键词: AODR mortality; Acute; Address; Adult; African American; Age; Age of Onset; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic Intoxication; Alcohols; Automobile Driving; Beer; Behavioral; Beverages; Birth; Caucasians; Caucasoid Race; Cessation of life; Chronic; Cognitive; Confounding Factors (Epidemiology); Cox Models; Cox Proportional Hazards Models; Criminal Justice; Data; Data Set; Dimensions; Drug usage; Education; Epidemiologic Studies; Epidemiology; Equilibrium; Ethanol; Ethnic Origin; Ethnic group; Extramural Activities; Frequencies; Gender; Health; Heavy Drinking; Hispanics; Illicit Drugs; Income; Individual; Injury; Interview; Life Cycle Stages; Liver Cirrhosis; Liver diseases; Longevity; Malignant Neoplasms; Marijuana; Marijuana Smoking; Marital Status; Measurement; Measures; Mexican; Mexican Americans; Modeling; Morbidity - disease rate; Myocardial Ischemia; National Institute on Alcohol Abuse and Alcoholism; Outcome; Pattern; Pharmaceutical Preparations; Policy Developments; Population; Prevention Research; Prevention strategy; Principal Investigator; Probability Samples; Procedures; Public Health; Public Health Practice; Race; Recommendation; Recording of previous events; Relative Risks; Research; Research Personnel; Risk; Risk Estimate; Risk Factors; Role; Sampling; Series; Smoking; Social isolation; Strategic Planning; Subgroup; Surveys; Testing; Time; Universities; Update; Weight; Wine; alcohol abuse therapy; alcohol effect; alcohol epidemiology; alcohol exposure; alcohol related problem; cohort; depression; design; distilled alcoholic beverage; drinking; evidence base; follow-up; health disparity; improved; indexing; meetings; mortality; preference; programs; prospective; public policy on alcohol; racial and ethnic; response; social

DESCRIPTION (provided by investigator): This revised application responds to PA-05-088 for secondary analysis of existing data to enhance understanding of drinking patterns and the epidemiology of alcohol-related problems-here, mortality. The PA's objectives will be met by aims addressing risk and protective factors in the US population and in white, black and Hispanic subpopulations of both genders (helping elucidate disparities in alcohol-related mortality), impact of drinking history on mortality, and methodological issues in pattern measurement and analysis including propensity score strategies. Recent alcohol mortality studies, including a successful R01 (AA10960, T.K. Greenfield, Principal Investigator), have found preliminary evidence of the role of drinking pattern, i.e., heavy drinking among low to mid-volume drinkers, in risk of all-cause mortality. Earlier analyses have been limited by lack of power, inadequate measurement, or both. This application uses two waves of the National Alcohol Survey (NAS) with unusually thorough measurement of drinking pattern, lifetime heavy drinking, and alcohol-related problems. It will extend from 11 to 21 (or if possible 22) years the National Death Index (NDI) follow up of the 1984 NAS (n = 5,221, response rate of 74 percent) adding a new 11- or 12-year follow up of the 1995 NAS (n = 4,950, response rate = 79 percent). Both surveys (ages 18 and older) were conducted face-to-face by Temple University ISR, used probability sampling with large black and Hispanic over-samples, and assessed many relevant identical items and scales. Drinking pattern measures include 12-month quantity/frequency of beer, wine, liquor and overall drinking, most drinks/day, former drinking and largest quantity, ever 5+ weekly, age of onset, etc. Smoking, drug use, depression/ demoralization, and many other risk factors are assessed. The common design permits pooling NASs, more than tripling number of expected deaths (to over 1,800 compared to the earlier R01's 532 deaths), yielding considerably greater power than heretofore for testing hypotheses about all-cause, ischemic heart disease (IHD) and cancer mortality, with exploratory analyses on injury and liver cirrhosis mortality. Analyses will disaggregate by gender and, where possible, by this and ethnic/racial group. Interactions between alcohol consumption and ethnicity will be modeled; theoretically important covariates and their interactions with alcohol measures will be added in a series of planned analyses, e.g., CES-D depression, social isolation, and other risk factors such as history of heavy drinking and alcohol problems, quitting because of health problems, alcohol treatment, drug use, and other variables. Results will inform public health strategies, alcohol policy development, and help disentangle pattern effects on mortality.

描述（由研究者提供）：此修订后的应用程序响应 PA-05-088，对现有数据进行二次分析，以加强对饮酒模式和酒精相关问题（此处为死亡率）流行病学的理解。 PA 的目标将通过解决美国人口以及白人、黑人和西班牙裔两性亚群的风险和保护因素（帮助阐明与酒精相关的死亡率的差异）、饮酒史对死亡率的影响以及方法学问题来实现。模式测量和分析，包括倾向评分策略。最近的酒精死亡率研究，包括成功的 R01（AA10960，T.K. Greenfield，首席研究员），已经发现了饮酒模式（即中低量饮酒者的大量饮酒）对全因死亡风险的影响的初步证据。早期的分析因缺乏动力、测量不充分或两者兼而有之。该应用程序使用两波国家酒精调查 (NAS)，对饮酒模式、终生酗酒和酒精相关问题进行异常彻底的测量。它将把 1984 年 NAS 的全国死亡指数 (NDI) 随访期从 11 年延长至 21 年（或者如果可能的话，22 年）（n = 5,221，答复率为 74%），并增加新的 11 年或 12 年随访期1995 年 NAS（n = 4,950，回复率 = 79%）。两项调查（18 岁及以上）均由坦普尔大学 ISR 面对面进行，使用概率抽样和大量黑人和西班牙裔过度样本，并评估了许多相关的相同项目和量表。饮酒模式测量包括 12 个月啤酒、葡萄酒、烈酒的数量/频率和整体饮酒量、每天饮酒次数、饮酒次数和最大量、每周 5 次以上、发病年龄等。 吸烟、吸毒、抑郁/士气低落，并评估许多其他风险因素。通用设计允许合并 NAS，使预期死亡人数增加两倍以上（与早期 R01 的 532 例死亡相比，达到 1,800 例以上），在检验全因死亡率、缺血性心脏病 (IHD) 和癌症死亡率的假设方面产生比以往更大的功效，对损伤和肝硬化死亡率进行探索性分析。分析将按性别分类，并在可能的情况下按民族/种族群体分类。酒精消费与种族之间的相互作用将被建模；理论上重要的协变量及其与酒精测量的相互作用将被添加到一系列计划的分析中，例如 CES-D 抑郁症、社会孤立以及其他风险因素，例如酗酒史和酒精问题、因健康问题戒烟、酒精治疗、药物使用和其他变量。结果将为公共卫生战略、酒精政策制定提供信息，并有助于理清对死亡率的模式影响。

项目成果

Ischemic heart disease mortality and morbidity rates in former drinkers: a meta-analysis.

以前饮酒者的缺血性心脏病死亡率和发病率：一项荟萃分析。

• 发表时间: 2011-02-01
• 影响因子: 5
• 作者: Roerecke, Michael;Rehm, Jürgen
• 通讯作者: Rehm, Jürgen