Midcareer Investigator Patient-oriented Research Award in Bronchiolitis & Asthma

职业生涯中期研究员毛细支气管炎患者导向研究奖

• 批准号: 7451393
• 负责人: Tina V Hartert
• 金额: $ 15.91万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7451393
• 关键词: Adult; Asthma; Award; Bronchiolitis; Causations; Child; Childhood; Childhood Asthma; Clinical; Clinical Research; Development; Disease; Environment; Environmental Risk Factor; Etiology; Genes; Genetic; Goals; Incidence; Infant; Infection; Intervention; Lower Respiratory Tract Infection; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Natural History; Persons; Predisposition; Preventive; Recurrence; Research Activity; Research Project Grants; Resistance; Respiratory Tract Infections; Respiratory syncytial virus; Rhinovirus; Risk; Risk Factors; Role; Severities; Thinking; Time; Translating; Variant; Viral; Virus; Virus Diseases; Wheezing; career; design; disorder prevention; functional outcomes; infancy; pathogen; respiratory

DESCRIPTION (provided by applicant): Immediate Goals: To determine the role of environmental and genetic factors on the development of both bronchiolitis and asthma, with the goal of designing and implementing more effective preventive therapies to reduce the incidence and severity of both infant viral infections and childhood asthma. Career Development Goals: To provide sufficient time for mentoring and research activities. Research Project: Asthma is thought to result from host (genetic) and environment interactions. Viral infections are one important, and modifiable environmental factor that have been established to be important causes of asthma exacerbations in both children and adults; lower respiratory tract infections (LRTI), caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants. Infants hospitalized with bronchiolitis are at significantly increased risk for both recurrent wheezing and childhood asthma. It is not known whether viral respiratory infections directly contribute to asthma causation or simply identify persons at risk for subsequent wheezing. Thus, many possible determinants exist that may contribute to the severity of bronchiolitis and the subsequent development of asthma. This proposal uses a combined, parallel clinical and experimental approach to evaluate the contribution of, causality, and mechanism of how viruses contribute to asthma causation and natural history, all relating to the central hypothesis that viruses, as one significant environmental factor, alter the risk for developing asthma, as well as the natural history of prevalent disease. Specific testable questions related to this hypothesis include: 1) the respiratory viral pathogen, environmental factors, and timing of infection during infancy impact the risk of developing childhood asthma; 2) lower respiratory viral infection during infancy, and the severity of that infection correlates with an increased risk of childhood asthma; 3) allelic variations at genes involved with severity of respiratory viral infection will correlate with a predisposition or resistance to both infant bronchiolitis and childhood asthma. The aims of the mentored award will be met by allowing the PI to translate her experimental expertise to direct clinical studies of progression and functional outcome of childhood viral illness and asthma, with the next goal to make the transition from risk factor determination to intervention and disease prevention.

描述（由申请人提供）：即时目标：确定环境和遗传因素对触支性炎和哮喘发展的作用，目的是设计和实施更有效的预防疗法，以降低婴儿病毒感染和儿童期哮喘的发病率和严重程度。 职业发展目标：为指导和研究活动提供足够的时间。 研究项目：哮喘被认为是由宿主（遗传）和环境相互作用引起的。病毒性的 感染是确定的重要且可修改的环境因素，是儿童和成人哮喘加重的重要原因。下呼吸道感染（LRTI）是由呼吸道合胞病毒（RSV）和鼻病毒（RV）等病毒引起的，是婴儿细支气管炎的主要原因。患有细支气管炎的婴儿对复发性喘息和儿童哮喘的风险显着增加。尚不清楚病毒呼吸道感染是否直接导致哮喘因果关系，或者只是识别有后续喘息风险的人。因此，存在许多可能导致细支气管炎严重程度和随后哮喘发展的决定因素。该提案使用一种合并的，平行的临床和实验方法来评估病毒如何促进哮喘因果关系和自然历史的贡献，因果关系和机制，所有这些都与中心假设有关，该假设是一种重要的环境因素，改变了一种重要的环境因素，改变了发展哮喘的风险，以及患病的自然病史。与该假设相关的特定可检验问题包括：1）婴儿期呼吸病毒病原体，环境因素和感染时机影响童年哮喘的患病风险； 2）婴儿期下呼吸道病毒感染，该感染的严重程度与儿童哮喘的风险增加有关； 3）与呼吸道病毒感染严重程度有关的基因的等位基因变异将与婴儿细支气管炎和儿童哮喘的倾向或抗性相关。 通过允许PI将她的实验专业知识转化为对儿童病毒疾病和哮喘的进展和功能结果的临床研究，将实现指导奖的目标，并将其下一个目标从确定危险因素确定转变为干预和预防疾病。