Core B: Biostatistics and Bioinformatics

核心B：生物统计学和生物信息学

• 批准号: 10601265
• 负责人: Ted Gooley
• 金额: $ 32.75万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-28 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601265
• 关键词: Core; Biostatistics; Bioinformatics

PROJECT SUMMARY/ABSTRACT Biostatistics & Bioinformatics: Core B This core provides centralized services to the program project in three related areas: biostatistics/bioinformatics, research computing, and data collection. The biostatisticians collaborate in all phases of research from study design, through interim analysis and monitoring, to final analysis and manuscript preparation. Biostatisticians were co-authors on over 81 manuscripts funded by this program project during the previous funding period and are integral parts of the protocol development and review process. The computing group is responsible for the maintenance and operation of shared computing systems. These include a cluster of Itanium machines that support a centralized patient database, known as Gateway, and a Sun workstation that supports statistical computing. The computing staff will create and maintain entry and reporting programs for Gateway, assist others in data extraction from the database, and maintain electronic connections to laboratory information which is downloaded directly to Gateway. The data collection group is responsible for data abstraction and entry into Gateway, and for maintenance of archival research files, which are stored in a web-accessible optical image library (OWL). The staff will follow an explicit protocol for data abstraction, coding, key entry, and quality control that is applied uniformly to all recipients entering research protocols within the Clinical Research Division, including protocols supported by this program project.

项目摘要/摘要 生物统计学和生物信息学：核心B 该核心在三个相关领域为计划项目提供集中服务： 生物统计学/生物信息学，研究计算和数据收集。生物统计学家合作 研究设计的阶段，从研究设计到临时分析和监测，最终分析和 手稿准备。生物统计学家是该计划资助的81多名手稿的合着者 在上一个资金期间项目项目，是协议开发和审查的组成部分 过程。计算组负责共享计算的维护和操作 系统。这些包括一组支持集中式患者数据库的Itanium机器 网关和支持统计计算的太阳工作站。计算人员将创建和 维护网关的输入和报告程序，帮助其他人从数据库中提取数据，然后 维护直接下载到Gateway的实验室信息的电子连接。数据 收集小组负责数据抽象和进入网关，并用于维护档案 研究文件，存储在可访问的光学图像库（OWL）中。工作人员将遵循 明确的数据抽象，编码，密钥输入和质量控制的协议均匀地应用于所有 获取临床研究部内研究方案的接收者，包括由 这个程序项目。