Interactive effects of physical activity and neighborhood air pollution on risk of incident Alzheimer's disease and related dementias

体力活动和社区空气污染对阿尔茨海默病和相关痴呆症风险的交互影响

• 批准号: 10816897
• 负责人: Wei Xu
• 金额: $ 11.99万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10816897
• 关键词: Interactive; effects; physical; activity; neighborhood

Project summary Physical activity is an important protective factor against dementia, a condition increasingly affecting older adults worldwide. Currently, only 26% of men and 19% of women in the U.S. are sufficiently active. Public health initiatives aimed at encouraging physical activity have the potential of decreasing population-level dementia risk and related social costs. However, cumulating evidence is highly suggestive that exposure to high levels of air pollution is associated with a greater risk of dementia. Given these countervailing effects, the neuroprotective benefits induced by physical activity could be inhibited if people exercise in polluted air. The lack of knowledge on the interactive effects of physical activity and air pollution prevents the formulation of most effective dementia prevention strategies. This proposed study aims to determine if physical activity interacts with neighborhood air pollution to impact dementia risk. In addition, we will examine if certain types of air pollutants have a greater moderating effect on the relationship between certain types of physical activity and risk of dementia subtypes. This project will use a large, population-based dataset on adults ages between 40 and 69 years from UK Biobank to longitudinally examine the independent and interactive effects of physical activity and air pollution on incident dementia over ten years. The primary objective of this two year project is to test the central hypothesis that exposure to neighborhood air pollution inhibits the protective effects of physical activity on risk of incident dementia.

项目摘要 体育活动是针对痴呆的重要保护因素，这种疾病越来越影响老年 全球成人。目前，美国只有26％的男性和19％的女性足够活跃。民众 旨在鼓励体育锻炼的健康计划有可能减少人口水平 痴呆症风险和相关的社会成本。但是，累积证据强烈暗示着暴露于 高水平的空气污染与更大的痴呆症风险有关。鉴于这些反击效果 如果人们在被污染的空气中运动，则由体育锻炼引起的神经保护益处可能会受到抑制。这 缺乏对体育活动和空气污染的互动效果的知识，无法制定 最有效的预防痴呆症策略。这项拟议的研究旨在确定是否体育锻炼 与邻里空气污染相互作用，以影响痴呆症风险。此外，我们将检查某些类型的 空气污染物对某些类型的体育活动之间的关系具有更大的调节作用 和痴呆症亚型的风险。该项目将在成年人之间使用大型，基于人群的数据集 从英国生物库到纵向研究物理的独立和互动效果的40年和69年 十年来，活动和空气污染对事件痴呆症。这个两年项目的主要目标是 测试中心假设，即暴露于邻里空气污染会抑制物理的保护作用 活动风险发生痴呆症的风险。