The interactive effects of physical activity and sedentary behaviors during childhood on adiposity in early adulthood

儿童期体力活动和久坐行为对成年早期肥胖的交互影响

• 批准号: 10217218
• 负责人: Soyang Kwon
• 金额: $ 7.65万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10217218
• 关键词: Accelerometer; Address; Adult; Advisory Committees; Aerobic; Age; American; Area; Attention; Behavior; Behavior Therapy; Birth; Body fat; Bone Development; Brazil; Child; Childhood; Cities; Cohort Studies; Collaborations; Country; Data; Data Pooling; Development; Dose; Dual-Energy X-Ray Absorptiometry; Fatty acid glycerol esters; Future; Growth; Guidelines; Health; Health Benefit; Health Policy; Health Professional; Heterogeneity; Hospitals; Hour; International; Intervention; Iowa; Knowledge; Longitudinal Studies; Measures; Modeling; Obesity; Outcome; Output; Parents; Participant; Pattern; Physical activity; Play; Policy Maker; Process; Reporting; Research; Research Personnel; Research Project Grants; Risk; Role; Sample Size; Sampling; Subgroup; Television; Testing; Time; Update; Weight Gain; Youth; base; behavior change; cohort; cost; data reduction; design; early childhood; emerging adult; evidence based guidelines; improved; indexing; obesity in children; obesity prevention; obesity risk; prevent; response; secondary analysis; sedentary; sedentary lifestyle; vigorous intensity; young adult

Project Summary The 2018 Physical Activity Guidelines Scientific Report, which summarized the most up-to-date evidence, suggested that, for youth the evidence for the effects of physical activity on obesity prevention is strong but the evidence for the effects of sedentary behavior remains limited. The report recognizes several important knowledge gaps, one of which is regarding the independent and interactive effects of physical activity and sedentary behavior on health outcomes. The abrupt difference in the physical activity guidelines across the transitional stage from youth to adulthood (e.g., daily one hour for youth vs. weekly 2.5 hours for adults) is also recognized as problematic. To address these gaps, we propose to conduct a pooled analysis to quantify the independent and interactive effects of physical activity and sedentary behavior on adiposity in early adulthood. The main hypotheses are (1) a healthier physical activity pattern during childhood and early adulthood is associated with lower adiposity in early adulthood, independent of sedentary behavior, and (2) a healthier sedentary behavior pattern is associated with lower adiposity in early adulthood only among those with a less healthy physical activity pattern. The first aim of this study is to examine the diverse trajectory patterns of moderate- and vigorous-intensity physical activity and sedentary behavior from age 11 to 24 years, using a group-based dual trajectory analysis approach. The second aim is to compare adiposity at age 22-24 years by moderate- and vigorous-intensity physical activity and sedentary behavior trajectory patterns. Two sub-aims are: to examine whether healthier physical activity and/or sedentary behavior patterns are associated with a lower risk of obesity at age 22-24 years among children with early childhood obesity; and to examine a dose- response relationship of moderate- and vigorous-intensity physical activity and sedentary behavior with fat mass change in the youth to adult transition period (from age 15-17 to 22-24 years). To achieve these aims, we will use pooled data from three birth cohort studies: U.K. Avon Longitudinal Study of Parents and Children, Brazil 1993 Pelotas Study, and U.S. Iowa Bone Development Study. The pooled data will enable us to have a diverse sample and sufficient power for the subgroup analysis. This low-cost self-contained R03 project is expected to produce new knowledge to update the Physical Activity Guidelines by addressing these knowledge gaps.

项目摘要 2018年体育活动指南科学报告，总结了最新证据， 建议，对于青年来说 久坐行为影响的证据仍然有限。该报告认识到几个重要的 知识差距，其中之一是关于体育活动的独立和互动效应 关于健康结果的久坐行为。整个体育活动指南的突然差异 从青年到成年的过渡阶段（例如，年轻人每天一小时与成人每周2.5小时）也是 被认为是有问题的。为了解决这些差距，我们建议进行汇总分析以量化 体育活动和久坐行为对成年早期肥胖的独立和互动效果。 主要的假设是（1）儿童期和成年早期的健康体育锻炼模式是 与成年初期的肥胖较低相关，独立于久坐行为，（2）更健康 久坐的行为模式与成年初期的肥胖性较低有关，仅在较少的人中 健康的体育锻炼模式。这项研究的第一个目的是检查各种轨迹模式 使用A 基于组的双轨迹分析方法。第二个目的是比较22-24岁的肥胖。 中等和剧烈的强度体育锻炼以及久坐的行为轨迹模式。两个子 是：检查更健康的身体活动和/或久坐行为模式是否与 幼儿肥胖儿童的肥胖风险较低22-24岁；并检查剂量 - 中等强度和剧烈的体育活动和久坐行为与脂肪的响应关系 年轻人到成人过渡期的质量变化（从15-17岁到22-24岁）。为了实现这些目标， 我们将使用三个出生队列研究的汇总数据：英国雅芳的父母和孩子纵向研究， 巴西1993 Pelotas研究和美国爱荷华州骨骼发展研究。汇总数据将使我们能够拥有一个 各种样本和足够的功率用于亚组分析。这个低成本的独立R03项目是 希望通过解决这些知识来产生新知识以更新体育活动指南 空白。

项目成果

The Joint Associations of Physical Activity and Sedentary Behaviors on Adiposity during Adolescence: The 1993 Pelotas (Brazil) Cohort Study.

• DOI: 10.3390/children10020265
• 发表时间: 2023-01-31
• 期刊: Children (Basel, Switzerland)

Longitudinal change in physical activity and adiposity in the transition from adolescence to early adulthood: the 1993 Pelotas cohort study.

体育活动的纵向变化和从青春期到成年早期的过渡：1993年Pelotas队列研究。

• DOI: 10.1186/s12966-022-01321-0
• 发表时间: 2022-07-14
• 期刊: INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
• 影响因子: 8.7
• 作者: Kwon, Soyang;Menezes, Ana M. B.;Ekelund, Ulf;Wehrmeister, Fernando C.;Goncalves, Helen;da Silva, Bruna Goncalves C.;Janz, Kathleen F.
• 通讯作者: Janz, Kathleen F.

Joint associations of physical activity and sedentary time with adiposity during adolescence: ALSPAC.

• DOI: 10.1093/eurpub/ckac023
• 发表时间: 2022-06-01
• 期刊: EUROPEAN JOURNAL OF PUBLIC HEALTH
• 影响因子: 4.4
• 作者: Kwon, Soyang;Ekelund, Ulf;Kandula, Namratha R.;Janz, Kathleen F.
• 通讯作者: Janz, Kathleen F.