Methamphetamine Research Program at Meharry Medical College

梅哈里医学院甲基苯丙胺研究项目

基本信息

批准号：
8433766
负责人：
Hubert K. Rucker
金额：
$ 8.15万
依托单位：
MEHARRY MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8433766
关键词：
Acute Address Adult Amphetamines Animal Model Applications Grants Award Behavioral Brain Cells Chronic Cocaine Data Dopamine Drug Addiction Drug abuse Educational Curriculum Environment Event Exposure to Faculty Future Goals Intervention Journals Learning Measurement Mediating Membrane Proteins Memory Methamphetamine Methamphetamine dependence Microscopy Midbrain structure Modeling Molecular Molecular Target Mutation Analysis N-terminal Neurons Parkinson Disease Pathology Pathway interactions Peer Review Perinatal Exposure Phosphotransferases Preparation Property Publications Publishing Research Research Personnel Research Project Grants Schizophrenia Serine Signal Transduction Testing Therapeutic Underserved Population base calmodulin-dependent protein kinase II cellular targeting cost effective dopamine transporter dopaminergic neuron fetal methamphetamine exposure health disparity in vivo interest medical schools member methamphetamine exposure novel novel strategies patch clamp pleasure prevent programs psychostimulant research study response reuptake symposium

项目摘要

DESCRIPTION (provided by applicant): The long-range goal of the proposed MIDARP program described in this application is to increase the capacity of Meharry Medical College to conduct rigorous research in drug abuse and addiction with an emphasis on health disparities and clinically underserved populations. The research program will seek to understand the molecular and behavioral basis for the in-vivo responses to acute and chronic methamphetamine (METH) exposures. We also plan to strengthen our intellectual environment and enhance the interest levels of trainees and faculty in drug abuse research. The Specific Aims of the Meharry Medical College MIDARP Program during the next five years are: 1. To publish at least 10 or more peer-reviewed publications in high-impact journals in drug abuse research; 2. To submit 4 or more applications for grants in drug abuse research by year-03 of the proposed award period; 3. To acquire 3 or more investigator-initiated awards by the end of year-05; and 4. To stimulate additional faculty and trainee interest in drug abuse research by curricula enhancement, seminars and symposia. One primary and one pilot research projects are proposed, all from junior investigators. In the primary project, Dr. H. Khoshbouei will characterize the biophysical properties of the dopamine transporter in response to METH versus amphetamine in an effort to understand the greater addictive potential of METH. Dr. Chirwa will characterize the impact of prenatal METH exposure on cellular (electrophysiological and molecular) correlates of adult memory and learning. This program will, thus, seek to understand the effect of Methamphetamine on the brain while stimulating the interests of other faculty members and trainees in drug abuse research.

描述（由申请人提供）：本申请中描述的拟议 MIDARP 计划的长期目标是提高梅哈里医学院对药物滥用和成瘾进行严格研究的能力，重点关注健康差异和临床服务不足的人群。该研究计划将寻求了解急性和慢性甲基苯丙胺（METH）暴露的体内反应的分子和行为基础。我们还计划加强我们的知识环境，提高学员和教师对药物滥用研究的兴趣水平。梅哈里医学院 MIDARP 计划未来五年的具体目标是： 1. 在药物滥用研究的高影响力期刊上发表至少 10 篇或更多经过同行评审的出版物； 2. 在拟议资助期的第 03 年之前提交 4 份或以上药物滥用研究资助申请； 3. 05年底前获得3项及以上研究者发起奖励； 4. 通过加强课程、研讨会和专题讨论会，激发更多教师和学员对药物滥用研究的兴趣。提出了一项主要研究项目和一项试点研究项目，全部来自初级研究人员。在主要项目中，H. Khoshbouei 博士将描述多巴胺转运蛋白对冰毒和安非他明的反应的生物物理特性，以了解冰毒更大的成瘾潜力。 Chirwa 博士将描述产前冰毒暴露对成人记忆和学习的细胞（电生理和分子）相关性的影响。因此，该计划将寻求了解甲基苯丙胺对大脑的影响，同时激发其他教职人员和学员对药物滥用研究的兴趣。