7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder

创伤后应激障碍受试者工作记忆期间代谢物变化的 7T 功能 MRS

基本信息

批准号：
10603379
负责人：
Meredith A Reid
金额：
$ 5.4万
依托单位：
AUBURN UNIVERSITY AT AUBURN
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-07-31
项目状态：
已结题

项目摘要

In response to NOT-MH-21-120 “Administrative Supplements for COVID-19 Impacted NIMH Research,” this application seeks additional support for the principal investigator to complete the aims of the Mentored Research Scientist Development Award number K01MH115272. The goal of the research project is to examine the neural mechanisms that contribute to working memory deficits in people with posttraumatic stress disorder (PTSD). This project combines 7T resting-state magnetic resonance spectroscopy (MRS), advanced dynamic functional MRS (fMRS), and functional magnetic resonance imaging (fMRI) to investigate the relationship between neurochemistry and brain activation during working memory in PTSD. The specific aims are to (1) measure glutamate and other metabolites in the dorsolateral prefrontal cortex (DLPFC) of people with and without PTSD using resting-state MRS; (2) investigate the relationship between resting-state levels of glutamate and functional activation during the n-back working memory task in people with and without PTSD using MRS and fMRI; and (3) characterize dynamic glutamate changes during working memory in people with and without PTSD using fMRS during the n-back task. The PI has made substantial progress towards completing these aims. However, the COVID-19 pandemic has caused significant delays in recruitment and data collection. In this application, we request supplemental support for the PI to offset the loss of time due to COVID-19, complete enrollment of human subjects, and fulfill the aims of the project.

为了回应非MH-21-120“ COVID-19的行政补品影响NIMH研究”，这申请为首席研究人员寻求额外的支持，以完成指导研究的目标科学家发展奖K01MH115272。研究项目的目的是检查神经有助于工作记忆的机制定义了创伤后应激障碍（PTSD）的机制。该项目结合了7T静止状态磁共振光谱（MRS），高级动态功能 MRS（FMR）和功能磁共振成像（fMRI）研究 PTSD的工作记忆过程中的神经化学和大脑激活。具体目的是（1）测量有或没有PTSD的人的谷氨酸和其他代谢物使用静止状态MRS；（2）研究谷氨酸静息状态与功能之间的关系使用MRS和fMRI的患者有或没有PTSD的患者的N-BACK工作记忆任务中的激活；和（3）表征有和没有PTSD的人使用的动态谷氨酸的变化 N后任务期间的FMR。 PI在完成这些目标方面取得了重大进展。然而， COVID-19大流行在招募和数据收集方面造成了重大延迟。在此应用程序中，我们请求对PI的补充支持，以抵消由于19号造成的时间损失，完全注册人类受试者，并实现该项目的目标。